Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion
Description Intervention
Criteria/Population
(%):
G1a: 56/67 (83.6)
Delong et al.,
2002 (continued)
Verbal ability, n:
G1a: 86
G1b: 38
Some verbal ability, n/N
(%):
G1a: 66 (77)
G1b: 20/38 (52.6)
No verbal ability, n:
G1a: 20
Hyperlexia, n (%):
G1a: 24 (27)
G1b: 1
C-374
Baseline
Measures Outcomes
without family
history of bipolar
disorder, n/N (%):
Families with
unusual
achievement &
bipolar disorder: 42/
76 (55)
Families without
unusual
achievement: 4/71
(6)
P < 0.001
Status of children
treated for >36
months, n/N:
Clinical regression:
18/30
Educational
placement, n/N:
Regular: 14/30
With other autism
children: 5/30
Home school: 3/30
Special classes:
3/30
With Bipolar
disorder: 5 males/30
(3 in regular class, 1
in learning disability
class, 1 clearly
autistic)
>3 years treatment
with Fluoxetine: 5
Other treatment
agents:
Lithium : 4
Valproate: 1
(3 discontinued
Fluoxetine)
Harms :
Incidence of
diarrhea / rash: 1
Mania: 1
Modifiers:
Treatment response
did not correlate
with age at starting
treatment (data NR)