Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention: Fluoxetine Inclusion criteria: NR Responders:
Delong et al., (0.15 to 0.5 mg/kg) for 5- • Children 2-8 years old
Fluoxetine
2002
Country:
76 months with
discontinuation trials
• CARS scores > 30
Exclusion criteria:
response, n (%):
Excellent: 22 (17)
US
Practice
setting:
Academic
Optimal dose was 4 to 8
mg/day or 15-40 mg/day
Assessments:
Family histories obtained
• Neurological /
chromosomal disorders
• Severe global
impairment
Good: 67 (52)
Fair/poor: 40 (31)
Fluoxetine response
by family history
Intervention
setting: Clinic
Enrollment
period: NR
Funding:
Agency:NR
Author industry
using family history Age, mean/yrs (range):
method in repeated 4.6 (2.83-7.5)
interviews; diagnosis Mental age:
validated by CARS NR
performed by TEACCH or Gender:
research team & ADOS M: NR
F: NR
Groups:
of major affective
disorder, n/N (%):
Excellent/good :
67/70 (85)
Poor/fair: 19/38 (50)
P < 0.001
Fluoxetine response
relationship
disclosures:
NR
G1a: Good / excellent
responders
G1b: Poor / fair
Race/ethnicity:
NR
by family history
of unusual
achievement, n/N
Design:
Retrospective
case series
responders
Co-interventions held
SES:
Maternal education: NR
(%):
With FH: 76/147
(52)
stable during treatment: Household income: NR
NR
Excellent/good
response: 52/76
Frequency of contact
during study: trials
Diagnostic approach:
In study
(68)
Poor/fair response:
16/76 (21)
discontinued after 1 year
for a period ranging from
4 days to several months
among those with
excellent/good response
Diagnostic tool/method:
Autism Diagnostic
Observation Schedule
(ADOS) & validated by
CARS
Without FH: 71/147
(48)
Excellent/good
response: 21/71
(30)
Poor/fair response:
34/71 (48)
P < 0.001
Delong et al.,
2002 (continued)
Concomitant therapies:
NR
N at enrollment:
155
N at follow-up:
129
Diagnostic category, n
(%):
Autism: 129 (100)
Other characteristics:
History of regression, n/N
(%):
G1a: 64/83 (77)
G1b: 22/36 (61)
P = 0.12
Family hx of MAD
+ family hx of BPD, n/N
(%):
G1a: 32/83 (38.6)
Regression of language &
social skills at the onset of
recognition of autism, n/N
C-373
Family history of
unusual
achievement with or
without major
affective disorder,
n/N (%):
Families with
unusual
achievement &
major affective
disorder: 69/76 (91)
Families without
unusual
achievement &
major affective
disorder: 37/71 (52)
P < 0.001
Family history of
unusual
achievement with or