Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Tsang et al., 2007 Chinese version of • Formally diagnosed with Merrill-Palmer raw Merrill-Palmer raw
Country: TEACCH for 12 months, PDD including autistic score, mean ± SD: scores, mean ±
China
7 hours/day, 5 days/week disorder and PDD-NOS G1: 29.22 ± 15.98 SD:
Practice vs. varied non-TEACCH by DSM-IV
G2: 49.62 ± 28.02 6 months:
setting:
full-time training, 5 days/ • No prior exposure to Merrill-Palmer G1: 40.78 ± 16.79
Academic week
structured teaching, mental age, mean ± G2: 59.75 ± 22.14
Intervention Assessments:
TEACCH
SD:
G1/BL: P ≤ 0.001
setting:
CPEP-R, Merrill Palmer • Randomly selected from G1: 28.11 ± 6.21 G2/BL: P ≤ 0.001
School
Scale and HKBABS preschool children with G2: 36.06 ± 10.94 G1/G2: P = NS*
Enrollment administered; context NR autism studying at Heep HKBABS sum of ANOVA: time
period:
Groups:
Hong Society (G1) standard scores, (P ≤ 0.001)
NR
G1: TEACCH training • Recruited from mean ± SD: 12 months:
Funding: G2: varied non-TEACCH Preschool Parents’ G1: 231.11 ± 22.99 G1: 48.00 ± 19.55
Providence Provider:
Association & Child G2: 290.69 ± 444.73 G1/6M: ≤ 0.01
Foundation NR
Assessment Centres of Educational/ ANOVA: time
Limited;
Measure of treatment the Department of cognitive/ (P ≤ 0.001)
Committee on fidelity reported:
Health (G2)
academic Merrill-Palmer
Conference and No
Exclusion criteria: attainment: mental age, mean
Research Grants, Co-interventions held • See inclusion criteria CPEP-R score, ± SD:
The University of stable during treatment: Age, years ± SD (range): mean ± SD: 6 months:
Hong Kong; Yes
G1: 4.06 ± 0.53 (3-5) Cognitive
G1: 32.78 ± 6.30
Research Grants Concomitant therapies: G2: 4.05 ± 0.73 (3-5) performance: G2: 40.12 ± 8.64
Council of the Individualized or group Mental age:
G1: 5.22 ± 2.65 G1/BL: P ≤ 0.001
Hong Kong treatment by speech, See baseline measures G2: 10.50 ± 7.47 G2/BL: P ≤ 0.001
Special
occupational or
Gender, n (%):
Cognitive verbal: G1/G2: P = NS*
Administrative physiotherapist as Male:
G1: 1.11 ± 1.28 12 months:
Region
needed; numbers NR G1: 17 (94.4)
G2: 8.44 ± 7.55 G1: 35.44 ± 7.38
Author industry N at enrollment: G2: 12 (75)
Developmental G1/6M: P ≤ 0.01
relationship G1: 18
Female:
scale total: ANOVA: time
disclosures: G2: 16
G1: 1 (5.6)
G1: 45.44 ± 13.67 (P ≤ 0.001)CPEP-
NR
N at 6 month follow-up: G2: 4 (25)
G2: 75.62 ± 32.03 R score, mean ±
Design: G1: 18
Race/ethnicity:
Social skills: SD:
Prospective cohort G2: 16
NR
HKBABS total HKBABS sum of
N at 12 month follow-up: SES:
score, mean ± SD: standard scores,
G1: 18
Maternal education: NR Socialization: mean ± SD:
G2: 2
Household income: NR G1: 27.06 ± 8.33 6 months:
Diagnostic approach: G2: 48.81 ± 15.98 G1: 226.39 ±
See inclusion criteria Communication/ 31.38
Diagnostic tool/method: language: G2: 315.19 ±
DSM-IV
CPEP-R score, 60.00
Diagnostic category: mean ± SD: G1/BL: P = NS
See inclusion creteria Imitation:
G2/BL: P ≤ 0.01
Other characteristics: G1: 4.22 ± 3.10 G1/G2: P ≤ 0.05*
IQ, mean ± SD:
G2: 8.19 ± 6.58 12 months:
G1: 59.97 ± 11.10 Perception: G1: 232.28 ±
G2: 74.22 ± 18.06 G1: 7.28 ± 2.56 31.86
G2: 8.88 ± 4.48 G1/6M: P = NS
ANOVA: time
(P ≤ NS)
C-256