Therapies for Children With Autism Spectrum Disorders

More documents

Recommendations

Info

Evidence Table. Therapies for children with ASD (continued) Study Inclusion/ Exclusion Baseline Description Intervention Criteria/ Population Measures Outcomes Practice Assessments: meeting DSM criteria 82/124 (66) (0.003-14.1) setting: Detailed chart review to • IQ or DQ ≥ 35 Psychostimulants: G1a: 4.5 ± 4.0 Academic Intervention abstract treatment information • Age 21 and younger Exclusion criteria: 65/124 (52) Number of stimu- (0.008-14.1) G1b: 2.3 ± 2.8 setting: Clinic Enrollment period: January 1976 to December 1997 Funding: Grant from Mr. and Mrs. David and Elaine Dana Author industry relationship disclosures: NR Design: Retrospective case series Episode of treatment: • Diagnosis of Rett lants used, n (%): (0.003-6.9) period of time subject disorder, CDD, or One: G1a/G1b: P = 0.03 treated with specific schizophrenia prior to G1: 32 (49) Average daily medication at specific fulfilling DSM-IV criteria Two: dose, mg MEUs ± dose, converted to for autism G1: 19 (29) SD (range): methylphenidate Age, onset of stimulant Three: G1: 27.3 ± 7.8 equivalent units (MEUs) treatment, years (range): G1: 14 (22) (2.5-75.2) Groups: G1: 7.9 ± 2.9 (3.4-14.5) Total episodes of G1a: 25.4 ± 15.3 G1: stimulant medication G1a: 7.0 ± 2.5 (3.4-14.2) psychostimulant (2.5-67.3) G2: other treatment G1b: 10.8 ± 2.4 (6.7-14.5) treatment, n: G1b: 34.1 ± 24.0 Ga: male G1a/G1b: P < 0.001 G1: 398 (5-75.2) Gb: female Mental age: Episodes of Favorable Co-interventions held NR psychostimulant response, n (%): stable during treatment: Gender, n (%): treatment, median G1: 276/398 (69) NR Male: per child (range): G1a: 235/345 (68) Frequency of contact Total: 95 (76.6) G1: 5 (1-21) G1b: 41/53 (77) during study: G1: 50 (76.9) Type of stimulant G1a/G1b: P = 0.33 NR Female: used, n (%): Favorable Concomitant therapies: Total: 29 (23.4) Methylphenidate: response by NR G1: 15 (23.1) G1: 52 (80) stimulant episodes, N at enrollment: Race/ethnicity: G1a: 41 (82) n (%): Total: 124 NR G1b: 11 (73) Methylphenidate: G1: 65 SES: Dextroampheta- 135/195 (69) N at follow-up: Maternal education: NR mine:Dextroampheta- NA Household income: NR G1: 34 (52) mine: 105/143 (73) Diagnostic approach: NR G1a: 29 (58) Mixed ampheta- Diagnostic tool/method: G1b: 5 (33) mine salts: 24/41 Review of records noting Mixed ampheta- (59) any reference to autism mine salts: Pemoline: 11/16 symptoms as per an G1: 13 (20) (69) autism glossary developed G1a: 11 (22) Methamphetamine: from 182 children given G1b: 2 (13) 1/3 (33) diagnoses of autism in the Pemoline: Harms: medical diagnosis index at G1: 11 (17) Experienced at the Mayo Clinic. School G1a: 9 (18) least one side and medical records of G1b: 2 (13) effect, n (%): children with ≥ 2 symptoms Methamphetamine: G1: 43/65 (66) noted were reviewed and G1: 2 (3) G1a: 36/50 (72) all noted symptoms were G1a: 2 (4) G1b: 7/15 (47) evaluated using DSM-IV G1b: 0 G1a/G1b: P = criteria 0.069 Nickels et al., Diagnostic category, n Side effects by 2008 (continued) (%): stimulant episodes, Autism: 124 (100) n (%): Other characteristics: Total: 67/398 Comorbid diagnoses, n (16.8) (%):* Methylphenidate: Speech/language: 31/195 (16) Total: 96 (77) Dextroampheta- Epilepsy: mine: 24/143 (17) Total: 17 (14) Mixed ampheta- Cognitive impairment mine salts: 7/41 (IQ/DQ < 70): (17) C-156
Evidence Table. Therapies for children with ASD (continued) Study Inclusion/ Exclusion Baseline Description Intervention Criteria/ Population Measures Outcomes Total: 68 (61) Pemoline: 4/16 (25) Methamphetamine: 1/3 (33) Methylphenidate side effects, n (# episodes): Tics: 4 (4) Appetite changes: 5 (6) Sleep disturbances: 6 (6) Headaches: 2 (2) Irritability/anxiousness/worsening of behavior: 9 (10) Sedation/lethargy/ sleepiness: 3 (4) Other: 2 (2) Dextroamphetamine side effects, n (# episodes): Tics: 2 (3) Appetite changes: 3 (5) Sleep disturbance: 4 (6 ) Irritability/anxiousness/worsening behavior: 10 (10) Sedation/lethargy/ sleepiness: 1 (1) Other: 1 (1) Unknown: 1 (1) Nickels et al., 2008 (continued) C-157 Mixed amphetamine salts side effects, n (# episodes): Tics: 1 (2) Sleep disturbances: 2 (2) Irritability/anxiousness/worsening behavior: 3 (3) Other: 2 (3) Pemoline side effects, n (# episodes): Tics: 1 (1) GI complaints/ stomach ache: 1 (1) Other: 2 (2) Methamphetamine side effects, n (# episodes): Tics: 1 (1)
Page 1 and 2:
Comparative Effectiveness Review Nu
Page 3 and 4:
This report is based on research co
Page 5 and 6:
Acknowledgments We are indebted to
Page 7 and 8:
Therapies for Children With Autism
Page 9 and 10:
Dietary and Other Medical Intervent
Page 11 and 12:
Figures Figure A. Analytic framewor
Page 13 and 14:
Table A. Description of interventio
Page 15 and 16:
Analytic Framework Figure A. Analyt
Page 17 and 18:
Strength of evidence. The degree of
Page 19 and 20:
epetitive behavior showed improveme
Page 21 and 22:
subgroups of children, although the
Page 23 and 24:
We encourage investigators to provi
Page 25 and 26:
9. Remington B, Hastings RP, Kovsho
Page 27 and 28:
46. Green J, Charman T, McConachie
Page 29 and 30:
82. Reaven JA, Blakeley-Smith A, Ni
Page 31 and 32:
120. Masi G, Cosenza A, Mucci M, et
Page 33 and 34:
157. Evangeliou A, Vlachonikolis I,
Page 35 and 36:
Introduction Need for Evidence for
Page 37 and 38:
Interventions intended primarily to
Page 39 and 40:
Table 1. Description of behavioral
Page 41 and 42:
Serotonin reuptake inhibitors. Sero
Page 43 and 44:
Table 3. Description of medical and
Page 45 and 46:
Table 4. Description of allied heal
Page 47 and 48:
Key Questions and Analytic Framewor
Page 49 and 50:
Chapter 4 discusses the results in
Page 51 and 52:
Methods This chapter documents proc
Page 53 and 54:
• Did not present aggregated resu
Page 55 and 56:
Additional behavioral interventions
Page 57 and 58:
1. Did the study employ a group des
Page 59 and 60:
Scoring: Studies minimally had to h
Page 61 and 62:
These ratings of applicability do n
Page 63 and 64:
Figure 2. Disposition of articles a
Page 65 and 66:
• ABA-based approaches including
Page 67 and 68:
education, children in the intensiv
Page 69 and 70:
abilities. This finding is further
Page 71 and 72:
Table 10. Outcomes of early intensi
Page 73 and 74:
forecast behavior; perspective taki
Page 75 and 76:
interaction with peers; outcome mea
Page 77 and 78:
hyperactivity, inattention, challen
Page 79 and 80:
Table 12. Outcomes of RCTs assessin
Page 81 and 82:
Schedule for Affective Disorders an
Page 83 and 84:
SCAS-P=Spence Child Anxiety Scale-P
Page 85 and 86:
Summary of the literature. Jarusiew
Page 87 and 88:
Table 14. Overview of educational s
Page 89 and 90:
on the Ankara Developmental Screeni
Page 91 and 92:
Checklist scores decreased by 8.4 f
Page 93 and 94:
Table 15. Outcomes of studies asses
Page 95 and 96:
evaluated the effects of risperidon
Page 97 and 98:
that this somnolence improved over
Page 99 and 100:
Table 17. Outcomes of RCTs of antip
Page 101 and 102:
Serotonin Reuptake Inhibitors SRIs
Page 103 and 104:
One prospective case series of esci
Page 105 and 106:
Most participants were recruited fr
Page 107 and 108:
Dietary and Other Medical Intervent
Page 109 and 110:
Summary of the literature-other int
Page 111 and 112:
withdrew after the first six weeks;
Page 113 and 114:
therefore described separately belo
Page 115 and 116:
addressed, 85 typically involves on
Page 117 and 118:
In the second paper, 89 treatment s
Page 119 and 120:
Table 25. Overview of CAM studies a
Page 121 and 122:
Teacher and Parent Scales, behavior
Page 123 and 124:
Because of the potentially increase
Page 125 and 126:
Educational Interventions Child cha
Page 127 and 128:
showed diminished response to escit
Page 129 and 130:
oom as the other assessments, so it
Page 131 and 132:
contrast group (n=18) on three meas
Page 133 and 134:
and are based on consideration of f
Page 135 and 136:
Few studies directly comparing the
Page 137 and 138:
Strength of evidence. The strength
Page 139 and 140:
While individual studies of CBT and
Page 141 and 142:
Table 32. Summary of results of edu
Page 143 and 144:
Table 33. Summary of results of med
Page 145 and 146:
strength of this reviewed literatur
Page 147 and 148:
Table 36. Intervention, strength of
Page 149 and 150:
Table 37. Interventions/outcomes wi
Page 151 and 152:
gains. 104 Other studies have seen
Page 153 and 154:
percent of behavioral studies repor
Page 155 and 156:
limited followup, lack of comparati
Page 157 and 158:
individual intervention is warrante
Page 159 and 160:
selecting participants for their st
Page 161 and 162:
studies lacked an arm that consider
Page 163 and 164:
23. Kanner L. Autistic Disturbances
Page 165 and 166:
62. Dosman CF, Drmic IE, Brian JA,
Page 167 and 168:
104. Ben-Itzchak E and Zachor DA. T
Page 169 and 170:
142. Tyminski RF and Moore PJ. The
Page 171 and 172:
177. Aman MG, McDougle CJ, Scahill
Page 173 and 174:
214. Correia CT, Almeida JP, Santos
Page 175 and 176:
252. Akhondzadeh S, Tajdar H, Moham
Page 177 and 178:
290. Dawson G, Rogers S, Munson J,
Page 179 and 180:
Acronyms/Abbreviations ABA Applied
Page 181 and 182:
Appendix A. Exact Search Strings an
Page 183 and 184:
Table A2. PsycINFO search strategie
Page 185 and 186:
Therapies for Children with Autism
Page 187 and 188:
Therapies for Children with ASD Sys
Page 189 and 190:
Appendix C. Evidence Tables Tables
Page 191 and 192:
Evidence Table. Therapies for child
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294: Evidence Table. Therapies for child
Page 343: Evidence Table. Therapies for child
Page 395 and 396:
Page 397 and 398:
Page 399 and 400:
Page 401 and 402:
Page 403 and 404:
Page 405 and 406:
Page 407 and 408:
Page 409 and 410:
Page 411 and 412:
Page 413 and 414:
Page 415 and 416:
Page 417 and 418:
Page 419 and 420:
Page 421 and 422:
Page 423 and 424:
Page 425 and 426:
Page 427 and 428:
Page 429 and 430:
Page 431 and 432:
Page 433 and 434:
Page 435 and 436:
Page 437 and 438:
Page 439 and 440:
Page 441 and 442:
Page 443 and 444:
Page 445 and 446:
Page 447 and 448:
Page 449 and 450:
Page 451 and 452:
Page 453 and 454:
Page 455 and 456:
Page 457 and 458:
Page 459 and 460:
Page 461 and 462:
Page 463 and 464:
Page 465 and 466:
Page 467 and 468:
Page 469 and 470:
Page 471 and 472:
Page 473 and 474:
Page 475 and 476:
Page 477 and 478:
Page 479 and 480:
Page 481 and 482:
Page 483 and 484:
Page 485 and 486:
Page 487 and 488:
Page 489 and 490:
Page 491 and 492:
Page 493 and 494:
Page 495 and 496:
Page 497 and 498:
Page 499 and 500:
Page 501 and 502:
Page 503 and 504:
Page 505 and 506:
Page 507 and 508:
Page 509 and 510:
Page 511 and 512:
Page 513 and 514:
Page 515 and 516:
Page 517 and 518:
Page 519 and 520:
Page 521 and 522:
Page 523 and 524:
Page 525 and 526:
Page 527 and 528:
Page 529 and 530:
Page 531 and 532:
Page 533 and 534:
Page 535 and 536:
Page 537 and 538:
Page 539 and 540:
Page 541 and 542:
Page 543 and 544:
Page 545 and 546:
Page 547 and 548:
Page 549 and 550:
Page 551 and 552:
Page 553 and 554:
Page 555 and 556:
Page 557 and 558:
Page 559 and 560:
Page 561 and 562:
Page 563 and 564:
Page 565 and 566:
Page 567 and 568:
Page 569 and 570:
Page 571 and 572:
Page 573 and 574:
Page 575 and 576:
Page 577 and 578:
Page 579 and 580:
Page 581 and 582:
Page 583 and 584:
Page 585 and 586:
Page 587 and 588:
Page 589 and 590:
Page 591 and 592:
Page 593 and 594:
Page 595 and 596:
Page 597 and 598:
Country: US Practice setting: Clini
Page 599 and 600:
Dunn-Geier et al., 2000 (continued)
Page 601 and 602:
Evidence Table: Therapies for Child
Page 603 and 604:
Page 605 and 606:
Page 607 and 608:
Appendix D. List of Excluded Studie
Page 609 and 610:
31. Aarsland D, Cummings JL and Lar
Page 611 and 612:
59. Ahearn WH, Clark KM, Gardenier
Page 613 and 614:
89. Allison DB, Basile VC and MacDo
Page 615 and 616:
118. Ando H, Yoshimura I and Wakaba
Page 617 and 618:
146. Atkinson RP, Jenson WR, Rovner
Page 619 and 620:
177. Bakare MO, Agomoh AO, Ebigbo P
Page 621 and 622:
204. Baron-Cohen S, Scott FJ, Allis
Page 623 and 624:
233. Bebko JM, Perry A and Bryson S
Page 625 and 626:
262. Bergmann F, Stepp H, Metzger R
Page 627 and 628:
291. Birkan B, McClannahan LE and K
Page 629 and 630:
319. Boddy F, Rowan EN, Lett D, et
Page 631 and 632:
348. Bouma R and Schweitzer R. The
Page 633 and 634:
376. Broadstock M, Doughty C and Eg
Page 635 and 636:
404. Brudnak MA. Application of gen
Page 637 and 638:
432. Buitelaar JK. Why have drug tr
Page 639 and 640:
460. Butler DE, Nordin IC, L’Ital
Page 641 and 642:
489. Campbell M, Locascio JJ, Choro
Page 643 and 644:
517. Caronna EB, Augustyn M and Zuc
Page 645 and 646:
546. Case-Smith J and Miller H. Occ
Page 647 and 648:
574. Charlop MH, Burgio LD, Iwata B
Page 649 and 650:
602. Cheng CW, Cho SH, Taylor M, et
Page 651 and 652:
631. Cicero FR and Pfadt A. Investi
Page 653 and 654:
662. Collier D and Reid G. A compar
Page 655 and 656:
691. Coskun M, Karakoc S, Kircelli
Page 657 and 658:
718. Cullen LA, Barlow JH and Cushw
Page 659 and 660:
748. Davidovitch M, Holtzman G and
Page 661 and 662:
777. DeLeon IG, Fisher WW and Marhe
Page 663 and 664:
805. Devlin SD, Harber MM. Collabor
Page 665 and 666:
834. Doherty K, Fitzgerald M and Ma
Page 667 and 668:
863. Dudley LL, Johnson C and Barne
Page 669 and 670:
893. Dybvik AC. Autism and the Incl
Page 671 and 672:
924. Elder JH. In-home communicatio
Page 673 and 674:
953. Erickson CA, Posey DJ, Stigler
Page 675 and 676:
979. Faja S, Aylward E, Bernier R,
Page 677 and 678:
1008. Ferri R, Elia M, Agarwal N, e
Page 679 and 680:
1037. Fisher W, Kerbeshian J and Bu
Page 681 and 682:
1066. Fragala-Pinkham M, Haley SM a
Page 683 and 684:
1095. Furneaux B. Keeping the balan
Page 685 and 686:
1124. Garcaa-Villamisar D, Wehman P
Page 687 and 688:
1152. Ghezzi PM. Discrete Trials Te
Page 689 and 690:
1180. Goin-Kochel RP, Myers BJ and
Page 691 and 692:
1210. Gordon R, Handleman JS and Ha
Page 693 and 694:
1239. Grimaldi BL. The central role
Page 695 and 696:
1268. Guptill JT, Booker AB, Gibbs
Page 697 and 698:
1296. Hamdan-Allen G. Brief report:
Page 699 and 700:
1324. Hare DJ, Jones JPR and Paine
Page 701 and 702:
1356. Harrison S and Berry L. Valui
Page 703 and 704:
1386. Heilbrun AB, Jr., Blum N and
Page 705 and 706:
1414. Hetzroni OE and Shalem U. Fro
Page 707 and 708:
1443. Holburn CS. Counter the mistr
Page 709 and 710:
1473. Horner RH, Carr EG, Strain PS
Page 711 and 712:
1504. Hughes C, Soares-Boucaud I, H
Page 713 and 714:
1533. Ijichi S and Ijichi N. Beyond
Page 715 and 716:
1562. James SJ, Cutler P, Melnyk S,
Page 717 and 718:
1591. Johnson CR, Butter EM, Handen
Page 719 and 720:
1619. Joyce PR. The medical model-w
Page 721 and 722:
1647. Karmali I, Greer RD, Nuzzolo-
Page 723 and 724:
1673. Kelly AB, Garnett MS, Attwood
Page 725 and 726:
1702. Kielinen M, Linna SL and Moil
Page 727 and 728:
1731. Klin A, Lin DJ, Gorrindo P, e
Page 729 and 730:
1761. Koegel RL and Frea WD. Treatm
Page 731 and 732:
1790. Kolmen BK, Feldman HM, Handen
Page 733 and 734:
1819. Kratochvil CJ, Findling RL, M
Page 735 and 736:
1846. Lam MK and Rao N. Developing
Page 737 and 738:
1874. Lattimore LP, Parsons MB and
Page 739 and 740:
1903. Lee PC. Verification of a sim
Page 741 and 742:
1932. Lerman DC, Vorndran C, Addiso
Page 743 and 744:
1960. Licciardello CC, Harchik AE a
Page 745 and 746:
1989. Liptak GS, Orlando M, Yinglin
Page 747 and 748:
2015. Lorimer PA, Simpson RL, Myles
Page 749 and 750:
2043. Luiselli JK, Kane A, Treml T,
Page 751 and 752:
2071. MacFarlane JR and Kanaya T. W
Page 753 and 754:
2099. Malone RP, Maislin G, Choudhu
Page 755 and 756:
2127. Marin FZ. CAM versus nucleopl
Page 757 and 758:
2157. Martineau J, Roux S, Adrien J
Page 759 and 760:
2185. Matson JL and Lo Vullo SV. A
Page 761 and 762:
2213. McCabe H. The Importance of P
Page 763 and 764:
2240. McDougle CJ, Holmes JP, Carls
Page 765 and 766:
2267. McHale SM, Olley JG, Marcus L
Page 767 and 768:
2296. Merlo LJ, Lehmkuhl HD, Geffke
Page 769 and 770:
2325. Minderaa RB, Anderson GM, Vol
Page 771 and 772:
2354. Montgomery JM, Duncan CR and
Page 773 and 774:
2385. Morrison RS, Sainato DM, Benc
Page 775 and 776:
2413. Munesue T, Ono Y, Mutoh K, et
Page 777 and 778:
2445. Napolitano DA, Tessing JL, Mc
Page 779 and 780:
2474. Niederhofer H and Pittschiele
Page 781 and 782:
2501. Nwora AJ and Gee BM. A case s
Page 783 and 784:
2530. Olive ML, Lang RB and Davis T
Page 785 and 786:
2559. Owens JA, Rosen CL and Mindel
Page 787 and 788:
2589. Pansegrouw I and Alant E. Com
Page 789 and 790:
2618. Paul C, Williams KE, Riegel K
Page 791 and 792:
2646. Perry R, Nobler MS and Campbe
Page 793 and 794:
2675. Piazza CC, Hagopian LP, Hughe
Page 795 and 796:
2704. Poon L, Partika N and Bolman
Page 797 and 798:
2734. Prizant BM. Speech-language p
Page 799 and 800:
2764. Rapp JT, Vollmer TR, St. Pete
Page 801 and 802:
2792. Reed P, Broomfield L, McHugh
Page 803 and 804:
2819. Remington G, Sloman L, Konsta
Page 805 and 806:
2849. Ringdahl JE, Kitsukawa K, And
Page 807 and 808:
2877. Rogers SJ. Interventions that
Page 809 and 810:
2908. Rossignol DA. Novel and emerg
Page 811 and 812:
2939. Rutter M, Kreppner J, Croft C
Page 813 and 814:
2967. Sandt D. Social Stories for S
Page 815 and 816:
2994. Scanlon K. Art therapy with a
Page 817 and 818:
3023. Schneider CK, Melmed RD, Bars
Page 819 and 820:
3054. Schwartz IS, Sandall SR, Garf
Page 821 and 822:
3085. Shafer MS, Egel AL and Neef N
Page 823 and 824:
3115. Shipley-Benamou R, Lutzker JR
Page 825 and 826:
3143. Siller M and Sigman M. The be
Page 827 and 828:
3173. Smith C, Felce D, Jones E, et
Page 829 and 830:
3202. Snyder A, Bossomaier T and Mi
Page 831 and 832:
3230. Spero MH. The emancipation of
Page 833 and 834:
3259. Stephens CE. Spontaneous imit
Page 835 and 836:
3289. Strambi M, Longini M, Hayek J
Page 837 and 838:
3318. Suzumura K. How an autistic b
Page 839 and 840:
3346. Tager-Flusberg H and Calkins
Page 841 and 842:
3376. Taylor I, O’Reilly M and La
Page 843 and 844:
3407. Thunberg G, Ahlsen E and Sand
Page 845 and 846:
3435. Trembath D, Balandin S, Toghe
Page 847 and 848:
3464. Turner-Brown LM, Perry TD, Di
Page 849 and 850:
3492. Van Der Putt R, Dineen C, Jan
Page 851 and 852:
3522. Vitiello B. Recent NIMH clini
Page 853 and 854:
3553. Walenski M, Mostofsky SH, Gid
Page 855 and 856:
3581. Weber RC and Thorpe J. Teachi
Page 857 and 858:
3610. Wheeler JJ, Baggett BA, Fox J
Page 859 and 860:
3637. Williams B. Mental handicap n
Page 861 and 862:
3669. Wimpory D, Chadwick P and Nas
Page 863 and 864:
3698. Worth S and Reynolds S. The A
Page 865 and 866:
3728. Young JM, Krantz PJ, McClanna
Page 867 and 868:
3759. Zuddas A, Di Martino A, Mugli
Page 869 and 870:
Appendix F. Approach to Categorizin
Page 871 and 872:
APPENDIX G. Discussion of Recent Sy
Page 873 and 874:
one a casein free regime. Diets wer
Page 875 and 876:
outcome data as Type 6, defined as
Page 877 and 878:
Yes—no disclosures to make G7 Bai
Page 879 and 880:
Table G1. Characteristics of recent
Page 881 and 882:
Random assignment Appropriate compa
Page 883 and 884:
Page 885 and 886:
Page 887 and 888:
Page 889 and 890:
Page 891 and 892:
Page 893 and 894:
Study Group design Random assignmen
Page 895 and 896:
Page 897 and 898:
Page 899 and 900:
Page 901 and 902:
Page 903 and 904:
Page 905 and 906:
APPENDIX I. Applicability Summary T
Page 907 and 908:
Social skills (continued) Domain De
show all

Therapies for Children With Autism Spectrum Disorders

Create successful ePaper yourself

Delete template?

Save as template?