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Therapies for Children With Autism Spectrum Disorders

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Evidence Table. <strong>Therapies</strong> <strong>for</strong> children with ASD<br />

Study<br />

Inclusion/Exclusion<br />

Description Intervention<br />

Criteria/Population<br />

Gabriels et al., Groups:<br />

2001 and 2007 G1a: children with<br />

(continued) developmental IQ >64 at<br />

1 st follow-up<br />

G1b: children with<br />

developmental IQ < 48 at<br />

1 st follow-up<br />

G1c: children with<br />

nonverbal intelligence<br />

(NVIQ) > 97 at 2 nd followup<br />

G1d: children with NVIQ<br />

score < 56 at 2 nd Household income: NR<br />

Hollingshead at 1<br />

follow-up<br />

st followup,<br />

mean ± SD (range):<br />

56.25 ± 10.68 (27.00-<br />

66.00)<br />

G1a: 54.88 ±12.6040<br />

G1b: 57.75 ± 8.61<br />

Hollingshead at 2 nd followup,<br />

mean ± SD:<br />

G1c: 58.63 ± 4.17<br />

G1d: 56.00 ± 8.07<br />

Diagnostic approach:<br />

In Study<br />

Gabriels et al.,<br />

2001 and 2007<br />

Provider:<br />

Community providers;<br />

details not reported<br />

Measure of treatment<br />

fidelity reported:<br />

No<br />

Co-interventions held<br />

stable during treatment:<br />

Yes<br />

<strong>Therapies</strong> at 1 st follow-up<br />

(parent report data), n:<br />

Structured home program:<br />

G1a: 5<br />

G1b: 5<br />

Private speech therapy:<br />

G1a: 9<br />

G1b: 7<br />

Private occupational<br />

therapy:<br />

G1a: 5<br />

G1b: 5<br />

Current public special<br />

education classroom:<br />

G1a: 5<br />

G1b: 6<br />

Current public integrated<br />

classroom with special<br />

education services:<br />

G1a: 3<br />

G1b: 2<br />

Current public integrated<br />

classroom (no special<br />

education services):<br />

G1a: 1<br />

G1b: 0<br />

Social tutoring:<br />

G1a: 1<br />

G1b: 0<br />

Vision therapy:<br />

G1a: 2<br />

Diagnostic tool/method:<br />

Initial diagnosis by clinic<br />

multidisciplinary team<br />

including a psychiatrist or<br />

psychologist with extensive<br />

experience in diagnosing<br />

early childhood autism;<br />

children re-diagnosed at<br />

time of first follow-up study<br />

using ADOS-G<br />

Diagnostic category at 1 st<br />

follow-up, n:<br />

<strong>Autism</strong>: 15<br />

PDD-NOS: 2<br />

Diagnostic category at<br />

2 nd follow-up, n:<br />

<strong>Autism</strong>: 12<br />

PDD-NOS: 2<br />

Other characteristics:<br />

Age began treatment,<br />

mean months ± SD:<br />

G1a: 33 ± 8.7<br />

G1b: 31 ± 5.9<br />

Total hours of treatment<br />

per month at 1 st follow-up,<br />

mean ± SD:<br />

G1a: 103.22 ± 66.33<br />

G1b: 76.25 ± 48.10<br />

Mean school-based<br />

treatment hours/week ± SD<br />

at 2 nd follow-up:<br />

G1c: 31.2 ± 3.8<br />

G1d: 33.8 ± 2.1<br />

Mean private treatment<br />

hours/week ± SD at 2 nd<br />

C-212<br />

Baseline<br />

Measures Outcomes<br />

PPVT-III standard<br />

score at 2 nd<br />

follow-up, mean ±<br />

SD:<br />

G1c: 101.50 ±<br />

12.62<br />

G1d: 46.83 ±<br />

16.74<br />

(t(12) = 6.99, P <<br />

0.001, G1c vs.<br />

G1d)<br />

VABS<br />

Communication<br />

score at 1 st followup,<br />

mean ± SD:<br />

G1c: 92.63 ±<br />

13.16<br />

G1d: 37.17 ±<br />

19.94<br />

VABS<br />

Communication<br />

score at 2 nd<br />

follow-up, mean ±<br />

SD:<br />

G1c: 115.50 ±<br />

7.93<br />

G1d: 49.83 ±<br />

27.12<br />

VABS<br />

Communication<br />

age-equivalent at<br />

2 nd follow-up,<br />

mean years ± SD:<br />

G1c: 8.49 ± 2.56<br />

G1d: 2.46 ± 1.62<br />

Adaptive<br />

behavior:<br />

Adaptive quotient<br />

at 1 st follow-up,<br />

mean ± SD<br />

G1a: 80.77 ±<br />

14.28<br />

G1b: 37.75 ±<br />

16.26<br />

P ≥ 0.01<br />

VABS standard<br />

composite score

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