Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
pathologist; providers DSM-IV criteria for HFA, (13-44)
G2a: 3.6 ± 2.5 (0working
with parents were PDDNOS or AS based on G1b: 2.25 ± 1.5 (1- 5)
a developmental and clinical interview
4)
G2b: 3.0 ± 1.2 (2behavioral
pediatrician Diagnostic category, N: G2a: 41.6 ± 30 (2- 4)
and a social worker G1a:
73)
G1-2/BL: P <
Groups:
Asperger’s Syndrome:3 G2b: 2.75 ± 0.5 (2- 0.001
G1: received curriculum High-Functioning Autism:1 3)
G1/G2: P = NS
G2: randomized to wait PDD-NOS:1
Children’s De- TOPS
list for later participation in G1b:
pression Inventory elementary-
curriculum (controls) Asperger’s Syndrome:2 score, mean ± SD revised, percentile
Ga: younger participants High-Functioning Autism:2 (range):
rank score, mean
with higher mean FSIQ G2a:
G1a: 6.0 ± 1.6 (4-8) ± SD (range):
Gb: older participants with Asperger’s Syndrome:5 G1b: 6.25 ± 4.3 (2- G1a: 43.2 ± 22
lower mean FSIQ G2b:
12)
(10-65)
Treatment manual Asperger’s Syndrome:2 Beck Depression G1b: 1.5 ± 1 (1followed:
High-Functioning Autism:2 Inventory score, 3)
No
Other characteristics: mothers, mean ± SD G2a: 23.8 ± 13 (6-
Co-interventions held ADOS mean (range): (range):
42)
stable during treatment: G1a: 9 (97-14)
G1: 5.9 ± 7.2 (0-20) G2b: 2.0 ± 1.2 (1-
NR
G1b: 15 (12-18)
Problem Behavior 3)
Concomitant therapies: G2a: 9 (7-13)
Logs, first 8 weeks, G1/BL: P < 0.05
NR
G2b: 14 (11-17)
mean:
G1/G2: P < 0.05
N at enrollment:
Problem behavior Children’s
G1: 9
reports per time: 9.6 Depression
G1a: 5
Parent satisfaction Inventory score,
G1b: 4
with their handling of mean ± SD
G2: 9
children’s problem (range):
G2a: 5
behavior: 6.2/10 G1a: 8.4 ± 5.0 (4-
G2b: 4
17)
N at follow-up:
G1b: 3.8 ± 3.2 (1-
G1: 9
7)
G1a: 5
G1a/G1b: P <
G1b: 4
0.05
G2: 9
Beck Depression
G2a: 5
Inventory score,
G2b: 4
mothers, mean ±
SD (range):
G1: 3.89 ± 3.3 (0-
9)
G1/BL: P = NS
Solomon et al.,
Problem Behavior
2004 (continued)
Logs, first 8
weeks, mean:
Problem behavior
reports per time:
5.9 (P < 0.05)
Parent satisfaction
with their
handling of
children’s problem
behavior: 6.9/10
(P = 0.11)
Harms:
NR
Modifiers:
Theory of Mind:
significant
C-344