Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Communication/ Educational/
Wong et al., 2007 Targeted intervention for • Preschool-aged children language: cognitive/
Country: play skills focused on with autism in early Developmental academic
US
improving functional and intervention program quotient, mean ± attainment:
Practice symbolic play skills;
setting: Academic targeted intervention for
Intervention joint attention skills.
setting:
Both interventions
• Staying in preschool
program > 1 month and
not involved in other
educational programs
SD:
G1: 58.90 ± 18.21
G2: 58.30 ± 17.18
Reynell develop-
Days to performance
mastery,
mean:
Naturalistic I
School
occurred daily for 30 Exclusion criteria: mental language conditions:
Enrollment
period:
NR
Funding:
NR
Author industry
relationship
disclosures:
NR
Design:
Prospective case
series
Note:
See related study
Gulsrud et al.
2007{#2578},
Jahromi et a.
2009{#3615},
Kasari et al.
2008{#184}, and
Kasari et al.
2006{#540}
minutes by trained • Seizures
age, months ± SD: G1: 3.24
interventionist: starting • On medication Receptive language G2: 5.32
with Naturalistic I • Associated sensory or G1: 21.00 ± 9.75 G1/G2: P < 0.05
conditions at the table for physical disorders G2: 20.55 ± 7.27 Naturalistic II
approximately 5-8
• Comorbidity with other
Expressive conditions:
minutes, followed by syndromes or diseases
language:
G1: 5.2
Naturalistic II floor Age, months ± SD:
G1: 21.43 ± 7.59 G2: 6.3
conditions for approxi- G1: 42.67 ± 6.92
G2: 20.60 ± 6.51 G1/G2: P = NS
mately 20-25 minutes G2: 43.2 ± 7.05
Harms:
Assessments:
Mental age, months ± SD:
NR
Before start of treatment: G1: 24.55 ± 8.09
Modifiers:
MSEL, RDLS, SPA, G2: 26.29 ± 8.71
Children with
ESCSA, M-CIA
Gender, n (%):
higher mental,
Groups:
Male:
receptive and
G1: play skills
G1: 16 (76)
expressive
G2: joint attention G2: 15 (75)
language age
Provider: Trained
Female:
reached mastery
interventionist
G1: 5 (24)
criteria in fewer
Measure of treatment G2: 5 (25)
days (P < 0.05)
fidelity reported: Race/ethnicity, n (%):
Significant
Yes
Caucasian:
interaction effect
Co-interventions held G1: 16 (76)
between teaching
stable during treatment: G2: 16 (80)
method and
NR
Hispanic:
child’s develop-
Concomitant therapies:
G1: 1 (5)
mental quotient
NR
G2: 0
(P = 0.02) for
N at enrollment:
Asian:
Naturalistic II
G1: 21
G1: 2 (10)
conditions.
G2: 20
G2: 1 (5)
N at follow-up:
Other:
Significant
G1: 21
G1: 2 (10)
interaction
G2: 20
G2: 3 (15)
between teaching
SES:
method & skill
Maternal education, n (%):
domain (F = 5.04,
High school:
P = 0.03).
G1: 3 (14)
G1 showed
G2: 0
mastery in
Some college:
significantly fewer
G1: 3 (14)
days than G2 in
G2: 2 (10)
the Naturalistic I
Special training after high
teaching
school:
environment.
G1: 1 (5)
G2: 0
Wong et al., 2007
Completed college:
(continued)
G1: 8 (38)
G2: 12 (60)
Graduate/professional
C-264