Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Legoff and Occupational therapy: Diagnostic tool/method:
PIQ, mean ± SD:
Sherman, 2006 G1: 1.24 ± 0.89
Diagnosis made on basis
G1: 99.3 ± 16.8
(continued) G2: 1.19 ± 0.88
of comprehensive
G2: 90.3 ± 18.1
G1/G2: P = NS
evaluations by a pediatric
Harms:
Physical therapy: neuropsychologist, a child
NR
G1: 0.21 ± 1.17
psychiatrist, a child
Modifiers:
G2: 0.57 ± 1.31
psychologist, and a speech
No main effect or
G1/G2: P = NS
pathologist, all of whom
interaction effect
Psychiatric medications, n were specialists in autism
for diagnostic
(%):
spectrum disorders
group (G1a, G1b,
Antipsychotics:
Diagnostic category, n
G2a, G2b) for
G1: 14 (23.3)
(%):
VABS-SD or
G2: 15 (26.3)
Autism:
GARS-SI
G1/G2: P = NS
G1: 26 (43.3)
In the autistic
Psychostimulants: G2: 24 (42.1)
disorder group,
G1: 18 (30.0)
Asperger’s:
GARS-SI
G2: 17 (29.8)
G1: 27 (45.0)
outcome was
G1/G2: P = NS
G2: 28 (49.1)
significantly
SSRI:
PDD-NOS:
correlated with
G1: 9 (15.0)
G1: 7 (11.7)
initial VABS-CD
G2: 8 (14.0)
G2: PDD-NOS: 5 (8.7)
and VIQ scores (P
G1/G2: P = NS
Other characteristics, n
< 0.05) and this
N at enrollment: (%):
relationship was
G1: 60
Diagnosis, axis II:
found in both the
G1a: 26
No diagnosis:
LEGO and
G1b: 34
G1: 41 (68.3)
comparison
G2: 57
G2: 39 (68.4)
groups
G2a: 24
Mild MR:
Communication
G2b: 33
G1: 16 (26.7)
ability (measured
N at follow-up:
G2: 15 (26.3)
by the VABS-CD
G1: 60
Moderate MR:
and VIQ) was
G1a: 26
G1: 2 (3.3)
significantly
G1b: 34
G2: 3 (5.3)
correlated with
G2: 57
MR unspecified:
outcome on the
G2a: 24
G1: 1 (1.7)
VABS-CD for both
G2b: 33
G2: 0 (0.0)
LEGO (P < 0.02)
and comparison
participants (P <
0.01)
Legoff and
Regression
Sherman, 2006
analyses of
(continued)
VABS-CD and
VIQ predicting
VABS-SD
difference scores:
G1+G2: P < 0.01
G1: P < 0.001
G2: P < 0.004
Ga: P = NS
Gb: P < 0.001
G1a: P < 0.021
G1b: P < 0.019
G2a: P = NS.
G2b: P < 0.004
Regression
analyses of
VABS-CD and
C-282