Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Gabriels et al.,
2001 and 2007
Combination of variety of
treatments (e.g.,
Country: TEACCH, LEAP or
US
Practice
setting:
Academic
Intervention
setting: home,
school, clinic
Enrollment
period:
NR
Funding:
Agency/NR
Author industry
relationship
disclosures:
NR
Design:
2001:
Retrospective
cohort with some
prospective data
collection
2007:Prospective
case series
DENVER Model) from
community providers over
a period of 37 months (1 st
follow up) or 5 years (2 nd
follow-up)
Assessments:
2001: Assessment
records were requested,
photocopied, placed in the
participant’s file, and
reviewed upon completion
of testing
Participants, with
parent(s) present,
completed testing in up to
3 sessions; MSEL, PLS-
III, & during 3 rd Inclusion criteria:
• Current diagnosis of
autistic disorder or PDD-
NOS
• At least 22 months postdiagnosis
• Available standardized
intellectual and/or
language functioning
scores at time of
diagnosis
Exclusion criteria:
• History of traumatic brain
injury
• History of seizure
disorder, fragile X, or
other known genetic or
biologic problems
No additional psychiatric
disorders
Age at diagnosis, mean
months ± SD (range):
session, 30.6 ± 7.27 (20-47)
subtests of Woodcock- Age at 1
Johnson Revised Tests of
Achievement and ADOS-
G
Participants were
evaluated by a team of
study evaluators,
consisting of a psychology
postdoctoral fellow, a
psychology intern, and a
speech-language clinical
fellow
2007: Leiter International
Performance Scale-
Revised (LIPS-R), VABS,
CCIF, Expressive One-
Word Picture Vocabulary
Test-Revised (EOWPVT-
R), and PPVT-III
st follow-up,
mean months ± SD
(range): 68.7 ± 10.11 (44-
88)
G1a: 69±9.3
G1b: 68±11.5
Mean age at 2 nd followup:
11.42
Age at 2 nd follow-up, mean
years ± SD:
G1c: 10.69 ± 0.72
G1d: 10.88 ± 0.74
Mental age:
NR
Gender, n:
M: 12 (10 at 2 nd follow-up)
F: 5 (4 at 2 nd follow-up)
Race/ethnicity, n:
Anglo: 14 (at 1 st and 2 nd
follow-up)
African American/Native
American: 1
Hispanic: 1
Asian: 1 (1 non-Anglo
ethnicity at 2 nd Educational/ Social skills:
cognitive/
academic
VABS
Socialization at 1
attainment:
Cognitive quotient at
diagnosis (n=16),
mean ± SD (range):
57.81 ± 25.88
(25.00-128.00)
G1a: 68.50 ± 30.78
G1b: 47.12 ± 15.06
Communication/
language:
Language quotient
at diagnosis (n=15),
mean ± SD (range):
42.46 ± 16.11 (5.00-
72.00)
G1a (n=7): 47.42 ±
12.48
G1b: 28.12 ± 18.43
follow-up)
SES:
Maternal education: NR
st
follow-up, mean ±
SD:
G1c: 64.75 ±
16.97
G1d: 38.50 ±
11.54
VABS
Socialization at
2 nd follow-up,
mean ± SD:
G1c: 84.38 ±
10.97
G1d: 39.33 ±
11.98
VABS
Socialization age
equivalent at 2 nd
follow-up, mean
years ± SD:
G1c: 5.54 ± 1.72
G1d: 1.78 ± 0.86
Communication/
language:
Language
quotient at 1 st
follow-up, mean ±
SD (range): 57.64
± 31.96 (16.00-
119.00)
G1a: 82.11 ±
22.23 (significant
increase
compared with
baseline, P =
0.01)
G1b: 30.12 ±
11.61
EOWPT standard
score at 2 nd
follow-up, mean±
SD:
G1c: 112.13 ±
9.09
G1d: 59.83 ±
11.84
(t(12) = 9.38, P <
0.001, G1c vs.
G1d)
C-211