Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Commonly Commonly
Dosman et al., Oral iron supplement: • Child had had ferritin occurring co- occurring co-
2007
6 mg elemental iron/kg/ measured previously as morbidities:morbidities: :
Country: day; if it was anticipated part of routine diagnostic CGIS irritability, CGIS irritability,
Canada
that oral preparations assessment from autism mean:
mean:
Practice would not be accepted by at The Hospital for Sick G1: 1.19 (n=32) G1: 1.0 (n=32)
setting:
the child, iron Sprinkles Children’s tertiary level Medical:
G1/BL: P = NS
Academic (Supple-Forte) were Child Development SDSC restless sleep Medical:
Intervention offered: two 30 mg Centre
score (1-5), mean ± SDSC restless
setting:
sachets/day
Exclusion criteria: SD:
sleep score,
Clinic
Enrollment
period:
Average duration of
treatment was 7.2 weeks
(range 4-8 weeks)
• Currently receiving iron
supplement
Age, years (range):
G1: 3.7 ± 1.450
(n=32)
G1c: 3.4 ± 1.60
showing
improvement, n
(%):
NR
Assessments:
G1: 6.5 (2.67-10.75) SDSC restless G1: 7/24 (29)
Funding: Prior to baseline and at Mental age:
sleep, abnormal, %: G1/BL: P = 0.04
NR
Author industry
post-treatment, parents
completed SDSC (26
NR
Gender, n:
G1: 77
SDSC delayed
SDSC delayed
sleep onset, n
relationship
disclosures:
NR
items), Periodic Leg
Movements during Sleep
scale (6 items), 3 day
Male: 27/33
Female: 6/33
Race/ethnicity:
sleep onset, n (%):
G1: 14/31 (44)
G1c: 5/8 (62.5)
(%):
G1: 11/31 (35)
G1/BL: P = NS
Design: Food Record, Nutritional NR
Periodic Leg Periodic Leg
Prospective case Supplement Log, and SES:
Movements during Movements
series
irritability measure Maternal education: NR Sleep, children with during Sleep,
(developed by authors Household income: NR mean score > 0.33, children with
based on CGIS) Diagnostic approach: n (%):
mean score >
Baseline and post NR
G1: 14/32 (44) 0.33, n (%):
treatment growth Diagnostic tool/method: Dietary iron intake, G1: 12/32 (38)
measures and blood ADI-R, ADOS, and clinical median mg/day G1/BL: P = NS
samples were taken for
serum ferritin and
evaluation
Diagnostic category:
(range):
G1a: 13.7 (4-39)
Dietary iron
intake, median
transferrin receptor, mean NR
corpuscular volume,
G1b: 17.85 (7-43)
Insufficient dietary
mg/day (range):
G1: NR
hemoglobin, albumin, and
iron intake, %: G1/BL: P = 0.32
vitamin B12 in the child
G1a: 69
Ferritin, mean
Groups:
G1b: 35
μg/L (range):
G1: iron intervention
Ferritin, mean μg/L G1: 28.8 (6.6-
Ga: preschool age (less
(range):
103)
than 6 years old)
G1: 15.72 (4.2-39.0) G1/BL: P < 0.001
G1a: school age (6 or
Low ferritin (< 10 Low ferritin ( 10 μg post-
G1a/G1b: P = NS G1/BL: P = NS
treatment
Albumin below Albumin, below
Gc: children on SSRI or
normal levels, n: normal levels n:
stimulant medication (and
G1: 0/32
G1: NR
completed SDSC)
Vitamin B12 below Vitamin B12,
Co-interventions held
normal levels, n: below normal
stable during treatment:
G1: 0/32
levels, n:
NR
Frequency of contact
during study:
NR
G1: 2/32
C-204