Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Overall ratings: Overall ratings:
Remington et al., Home-based early inter- • Autism diagnosis from DBC total score, DBC total score,
2007
vention for two years, ADI-R
mean ± SD: mean ± SD:
Country:
UK
Practice
setting:
Academic
Intervention
setting:
Home, school,
clinic
Enrollment
period:
NR
Funding:
UK Health
Foundation
Author industry
relationship
disclosures:
NR
Design:
Cohort,
prospective
25.6 ± 4.8 hours/week • Previously diagnosed Maternal report: Maternal report:
(range 18.4-34.0 hours); with autism by an G1: 50.26 ± 22.75 G1: 44.70 ± 24.20
one-on-one intervention independent clinician, or G2: 67.81 ± 18.77 G2: 60.62 ± 24.72
provided by parents and suspected autism Paternal report: Paternal report:
3-5 trained tutors; pro- diagnosis
G1: 46.67 ± 22.15 G1: 45.19 ± 20.94
grams used discrete trial • Age 30-42 months at G2: 57.57 ± 15.67 G2: 55.20 ± 19.44
training and incorporated enrollment
DBC autism score, DBC autism
generalization procedures • Children lived in the mean ± SD: score, mean ±
(specific programming family home
Maternal report: SD:
individualized for each Exclusion criteria: G1: 22.22 ± 9.54 Maternal report:
child), participants were • Other chronic or serious G2: 31.14 ± 9.22 G1: 18.91 ± 10.29
identified based on parent medical conditions that Paternal report: G2: 26.76 ± 11.21
preference for EIBI would interfere with G1: 22.33 ± 9.92 Paternal report:
(funded either publicly consistency of inter- G2: 26.29 ± 8.90 G1: 19.50 ± 8.80
n=13 or purchased vention
ASQ score, mean ± G2: 24.00 ± 11.60
privately n=10)
Age, months ± SD: SD:
ASQ score, mean
Controls had local G1: 35.7 ± 4.0
Maternal report: ± SD:
education authorities’ G2: 38.4 ± 4.4
G1: 19.26 ± 4.93 Maternal report:
standard treatment for two G1/G2: P < 0.05
G2: 21.14 ± 5.47 G1: 15.96 ± 5.63
years; in general not Mental age:
Paternal report: G2: 19.29 ± 7.22
intensive or delivered See baseline measures G1: 20.88 ± 4.54 Paternal report:
one-to-one
Gender:
G2: 21.07 ± 6.41 G1: 19.88 ± 6.16
Assessments:
NR
Social skills: G2: 19.47 ± 7.46
Performance-based tests Race/ethnicity:
NCBRF positive Social skills:
administered at family NR
social behavior NCBRF positive
home, parents mailed SES:
score, mean ± SD: social behavior
questionnaires, telephone University education, Maternal report: score, mean ±
interviews using VABS maternal, n (%):
G1: 10.57 ± 4.24 SD:
approximately 1 week G1: 10/23 (43)
G2: 9.29 ± 3.47 Maternal report:
prior to the children’s 60 G2: 4/21 (19)
Paternal report: G1: 15.30 ± 4.69
minute assessment visits Household income: NR G1: 8.94 ± 3.47 G2: 11.86 ± 4.84
at 3 time points (baseline, Mother working, n (%): G2: 8.73 ± 3.67 G1/G2: P = 0.004
1 and 2 year follow-up); Full time:
Communication/ Paternal report:
ADI administered by first G1: 0
language: G1: 12.60 ± 4.06
author, ESCS, BSID or G2: 0
ESCS joint attention G2: 11.20 ± 5.19
Stanford Binet, and RDLS Part time:
score, mean ± SD: G1/G2: P = 0.053
were administered by a G1: 7 (30.4)
Initiating:
Communication/
Master’s level psycho- G2: 7 (33.3)
G1: 3.33 ± 4.40 language:
metrician
Fathers (living in the family G2: 3.63 ± 4.92 ESCS joint
Groups:
home) working, n (%): Responding: attention score,
G1: EIBI intervention Full time:
G1: 5.29 ± 3.62 mean ± SD:
G2: treatment as usual G1: 19/20 (95)
G2: 5.94 ± 3.91 Initiating:
through public funds G2: 17/20 (85)
Reynell verbal G1: 11.76 ± 9.41
Provider:
Part time:
comprehension G2: 11.19 ± 13.86
Parents and trained G1: 0
score obtained, n: G1/G2: P = NS
tutors, supervised by G2: 1/20 (5)
G1: 4
Responding:
more experienced Diagnostic approach: G2: 3
G1: 11.29 ± 3.47
behavior analysts, in Referral
G1/G2: P = NS G2: 10.06 ± 4.99
some cases a consultant
G1/G2: P < 0.05
with PhD experience in
behavior analysis
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