Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Communication/ Overall ratings:
RUPP, 2007 11 parent education • Age 4-13 years language: CGI-I rating, %:
Country: sessions covering • On stable medication for ABLLS raw score, Very much
US
Practice
setting:
prevention strategies,
schedules, reinforcement,
planned ignoring,
significant behavior
problems (stable = on
same medication dose
mean ± SD: improved/much
G1: 133.4 ± 64.2 improved: 53
Problem behavior: Minimal
Specialty compliance training, for ≥ 4 weeks with no ABC score, mean ± improvement: 30
treatment center
Intervention
setting:
Clinic and home
Enrollment
period:
NR
Funding:
NIH
Author industry
relationship
disclosures:
NR
Design:
Case series
functional communication planned dosage SD:
No change: 6
techniques, teaching changes for 6 months) Irritability:
Parent rating of
techniques, and • At least one parent G1: 24.3 ± 9.3 target behaviors
generalization; up to 4 available for training Stereotypic improved, highly
optional sessions • Met clinical DSM-IV behavior:
satisfied: 100
including time-out, criteria for Autistic G1: 8.8 ± 5.7 Communication/
contingency contracting, Disorder, Asperger’s Lethargy/social language:
imitation training, and Disorder, or PDD-NOS withdrawal: ABLLS raw score,
crisis management • CGI-S score of 3-5 at G1: 9.5 ± 8.2 week 24, mean ±
implemented at clinician baseline
Hyperactivity/ SD:
discretion
Exclusion criteria: noncompliance: G1: 159 ± 56.4
Mean parental adherence • IQ < 35 or mental age
G1: 27.4 ± 9.5 G1/BL: P < 0.001
score for 11 mandatory