Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Impairment in nonverbal
changes in GI
behaviors:
symptoms, %:
G1: 97
26
G2: 100
Formed stools at
Failure to develop peer
enrollment, %:
relationships:
Subjects who
G1: 97
displayed sus-
G2: 100
tained change: 89
Lack of spontaneous
Subjects who did
relationships with others:
not display sus-
G1: 52
tained change: 42
G2: 75
(P = 0.02)
Lack of social or emotional
No differences in
reciprocity:
average stools/
G1: 48
day or presence
G2: 71
of blood in stools
Delay in or total lack of
were noted
spoken language:
Harms:
G1: 97
Parents observed
G2: 82
side effects since
In those without severe
injection (transient
language impairment,
irritability; hyper-
inability to initiate or
activity; nausea/
sustain conversation with
vomiting), %: 13
others:
Modifiers:
G1: 55
Correlation of PLS
G2: 50
and CARS score:
Stereotyped or repetitive
Baseline: -0.57 (P
use of language:
< 0.000)
G1: 43
3 weeks: -0.44
G2: 57
(P < 0.001)
Lack of spontaneous
6 weeks: -0.3
make-believe or social
(P < 0.004)
play:
No significant
G1: 72
correlation
G2: 75
between PLS and
Preoccupation with one or
more stereotypes:
G1: 83
G2: 89
Inflexible adherence to
routines or rituals:
G1: 48
G2: 57
GARS
Coniglio et al.,
Stereotyped and repetitive
2001 (continued)
motor mannerisms:
G1: 83
G2: 79
Persistent preoccupation
with parts of objects:
G1: 55
G2: 54
Delay in social interaction:
G1: 90
G2: 93
Delay in language:
G1: 100
C-392