Therapies for Children With Autism Spectrum Disorders

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791. Dennis M, Lockyer L, Lazenby AL, et al. Intelligence patterns among children with highfunctioning autism, phenylketonuria, and childhood head injury. J Autism Dev Disord. 1999 Feb;29(1):5-17. X-1, X-2, X-3, X-4, X-10 792. DeQuinzio JA, Townsend DB and Poulson CL. The Effects of Forward Chaining and Contingent Social Interaction on the Acquisition of Complex Sharing Responses by Children with Autism. Research in Autism Spectrum Disorders. 2008 Apr-Jun;2(2):264- 275. X-3 793. DeQuinzio JA, Townsend DB, Sturmey P, et al. Generalized imitation of facial models by children with autism. J Appl Behav Anal. 2007 Winter;40(4):755-9. X-3 794. DeStefano F, Bhasin TK, Thompson WW, et al. Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a populationbased study in metropolitan atlanta. Pediatrics. 2004 Feb;113(2):259-66. X-4 795. DeStefano F and Chen RT. Autism and measles, mumps, and rubella vaccine: No epidemiological evidence for a causal association. J Pediatr. 2000 Jan;136(1):125-6. X-1, X-2, X-3, X-4 796. DeThorne LS, Johnson CJ, Walder L, et al. When “Simon says” doesn’t work: alternatives to imitation for facilitating early speech development. Am J Speech Lang Pathol. 2009 May;18(2):133-45. X-1, X-2, X-3 797. Dettmer S, Simpson RL, Myles BS, et al. The use of visual supports to facilitate transitions of students with autism. Focus on Autism and Other Developmental Disabilities. 2000 Fal;15(3):163-169. X-3 798. Deurell M, Weischer M, Pagsberg AK, et al. The use of antipsychotic medication in child and adolescent psychiatric treatment in Denmark. A cross-sectional survey. Nord J Psychiatry. 2008;62(6):472-80. X-4 799. Deutsch SI. Rationale for the administration of opiate antagonists in treating infantile autism. Am J Ment Defic. 1986 May;90(6):631-5. X-1, X-2, X-3, X-4, X-10 800. Deutsch SI, Campbell M. Relative affinities for different classes of neurotransmitter receptors predict neuroleptic efficacy in infantile autism: a hypothesis. Neuropsychobiology. 1986;15(3-4):160-4. X-10 801. Deutsch SI, Campbell M, Perry R, et al. Plasma growth hormone response to insulininduced hypoglycemia in infantile autism: a pilot study. J Autism Dev Disord. 1986 Mar;16(1):59-68. X-3, X-4, X-10 802. Deutsch SI, Milstoc M, Platovsky G, et al. Cholinesterase activities in blood in infantile autism. Biol Psychiatry. 1987 Feb;22(2):234-6. X-4, X-10 803. Devlin S, Healy O, Leader G, et al. The Analysis and Treatment of Problem Behavior Evoked by Auditory Stimulation. Research in Autism Spectrum Disorders. 2008 Oct;2(4):671-680. X-3 804. Devlin S, Leader G, Healy O. Comparison of Behavioral Intervention and Sensory- Integration Therapy in the Treatment of Self-Injurious Behavior. Research in Autism Spectrum Disorders. 2009 Jan;3(1):223-231. X-3 D-56
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Comparative Effectiveness Review Nu
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This report is based on research co
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Acknowledgments We are indebted to
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Therapies for Children With Autism
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Dietary and Other Medical Intervent
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Figures Figure A. Analytic framewor
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Table A. Description of interventio
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Analytic Framework Figure A. Analyt
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Strength of evidence. The degree of
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epetitive behavior showed improveme
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subgroups of children, although the
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We encourage investigators to provi
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9. Remington B, Hastings RP, Kovsho
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46. Green J, Charman T, McConachie
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82. Reaven JA, Blakeley-Smith A, Ni
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120. Masi G, Cosenza A, Mucci M, et
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157. Evangeliou A, Vlachonikolis I,
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Introduction Need for Evidence for
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Interventions intended primarily to
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Table 1. Description of behavioral
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Serotonin reuptake inhibitors. Sero
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Table 3. Description of medical and
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Table 4. Description of allied heal
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Key Questions and Analytic Framewor
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Chapter 4 discusses the results in
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Methods This chapter documents proc
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• Did not present aggregated resu
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Additional behavioral interventions
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1. Did the study employ a group des
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Scoring: Studies minimally had to h
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These ratings of applicability do n
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Figure 2. Disposition of articles a
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• ABA-based approaches including
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education, children in the intensiv
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abilities. This finding is further
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Table 10. Outcomes of early intensi
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forecast behavior; perspective taki
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interaction with peers; outcome mea
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hyperactivity, inattention, challen
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Table 12. Outcomes of RCTs assessin
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Schedule for Affective Disorders an
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SCAS-P=Spence Child Anxiety Scale-P
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Summary of the literature. Jarusiew
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Table 14. Overview of educational s
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on the Ankara Developmental Screeni
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Checklist scores decreased by 8.4 f
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Table 15. Outcomes of studies asses
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evaluated the effects of risperidon
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that this somnolence improved over
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Table 17. Outcomes of RCTs of antip
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Serotonin Reuptake Inhibitors SRIs
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One prospective case series of esci
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Most participants were recruited fr
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Dietary and Other Medical Intervent
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Summary of the literature-other int
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withdrew after the first six weeks;
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therefore described separately belo
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addressed, 85 typically involves on
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In the second paper, 89 treatment s
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Table 25. Overview of CAM studies a
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Teacher and Parent Scales, behavior
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Because of the potentially increase
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Educational Interventions Child cha
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showed diminished response to escit
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oom as the other assessments, so it
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contrast group (n=18) on three meas
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and are based on consideration of f
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Few studies directly comparing the
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Strength of evidence. The strength
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While individual studies of CBT and
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Table 32. Summary of results of edu
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Table 33. Summary of results of med
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strength of this reviewed literatur
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Table 36. Intervention, strength of
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Table 37. Interventions/outcomes wi
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gains. 104 Other studies have seen
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percent of behavioral studies repor
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limited followup, lack of comparati
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individual intervention is warrante
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selecting participants for their st
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studies lacked an arm that consider
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23. Kanner L. Autistic Disturbances
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62. Dosman CF, Drmic IE, Brian JA,
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104. Ben-Itzchak E and Zachor DA. T
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142. Tyminski RF and Moore PJ. The
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177. Aman MG, McDougle CJ, Scahill
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214. Correia CT, Almeida JP, Santos
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252. Akhondzadeh S, Tajdar H, Moham
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290. Dawson G, Rogers S, Munson J,
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Acronyms/Abbreviations ABA Applied
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Appendix A. Exact Search Strings an
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Table A2. PsycINFO search strategie
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Therapies for Children with Autism
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Therapies for Children with ASD Sys
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Appendix C. Evidence Tables Tables
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Evidence Table. Therapies for child
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Country: US Practice setting: Clini
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Dunn-Geier et al., 2000 (continued)
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Evidence Table: Therapies for Child
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Appendix D. List of Excluded Studie
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31. Aarsland D, Cummings JL and Lar
Page 611 and 612: 59. Ahearn WH, Clark KM, Gardenier
Page 613 and 614: 89. Allison DB, Basile VC and MacDo
Page 615 and 616: 118. Ando H, Yoshimura I and Wakaba
Page 617 and 618: 146. Atkinson RP, Jenson WR, Rovner
Page 619 and 620: 177. Bakare MO, Agomoh AO, Ebigbo P
Page 621 and 622: 204. Baron-Cohen S, Scott FJ, Allis
Page 623 and 624: 233. Bebko JM, Perry A and Bryson S
Page 625 and 626: 262. Bergmann F, Stepp H, Metzger R
Page 627 and 628: 291. Birkan B, McClannahan LE and K
Page 629 and 630: 319. Boddy F, Rowan EN, Lett D, et
Page 631 and 632: 348. Bouma R and Schweitzer R. The
Page 633 and 634: 376. Broadstock M, Doughty C and Eg
Page 635 and 636: 404. Brudnak MA. Application of gen
Page 637 and 638: 432. Buitelaar JK. Why have drug tr
Page 639 and 640: 460. Butler DE, Nordin IC, L’Ital
Page 641 and 642: 489. Campbell M, Locascio JJ, Choro
Page 643 and 644: 517. Caronna EB, Augustyn M and Zuc
Page 645 and 646: 546. Case-Smith J and Miller H. Occ
Page 647 and 648: 574. Charlop MH, Burgio LD, Iwata B
Page 649 and 650: 602. Cheng CW, Cho SH, Taylor M, et
Page 651 and 652: 631. Cicero FR and Pfadt A. Investi
Page 653 and 654: 662. Collier D and Reid G. A compar
Page 655 and 656: 691. Coskun M, Karakoc S, Kircelli
Page 657 and 658: 718. Cullen LA, Barlow JH and Cushw
Page 659 and 660: 748. Davidovitch M, Holtzman G and
Page 661: 777. DeLeon IG, Fisher WW and Marhe
Page 665 and 666: 834. Doherty K, Fitzgerald M and Ma
Page 667 and 668: 863. Dudley LL, Johnson C and Barne
Page 669 and 670: 893. Dybvik AC. Autism and the Incl
Page 671 and 672: 924. Elder JH. In-home communicatio
Page 673 and 674: 953. Erickson CA, Posey DJ, Stigler
Page 675 and 676: 979. Faja S, Aylward E, Bernier R,
Page 677 and 678: 1008. Ferri R, Elia M, Agarwal N, e
Page 679 and 680: 1037. Fisher W, Kerbeshian J and Bu
Page 681 and 682: 1066. Fragala-Pinkham M, Haley SM a
Page 683 and 684: 1095. Furneaux B. Keeping the balan
Page 685 and 686: 1124. Garcaa-Villamisar D, Wehman P
Page 687 and 688: 1152. Ghezzi PM. Discrete Trials Te
Page 689 and 690: 1180. Goin-Kochel RP, Myers BJ and
Page 691 and 692: 1210. Gordon R, Handleman JS and Ha
Page 693 and 694: 1239. Grimaldi BL. The central role
Page 695 and 696: 1268. Guptill JT, Booker AB, Gibbs
Page 697 and 698: 1296. Hamdan-Allen G. Brief report:
Page 699 and 700: 1324. Hare DJ, Jones JPR and Paine
Page 701 and 702: 1356. Harrison S and Berry L. Valui
Page 703 and 704: 1386. Heilbrun AB, Jr., Blum N and
Page 705 and 706: 1414. Hetzroni OE and Shalem U. Fro
Page 707 and 708: 1443. Holburn CS. Counter the mistr
Page 709 and 710: 1473. Horner RH, Carr EG, Strain PS
Page 711 and 712: 1504. Hughes C, Soares-Boucaud I, H
Page 713 and 714:
1533. Ijichi S and Ijichi N. Beyond
Page 715 and 716:
1562. James SJ, Cutler P, Melnyk S,
Page 717 and 718:
1591. Johnson CR, Butter EM, Handen
Page 719 and 720:
1619. Joyce PR. The medical model-w
Page 721 and 722:
1647. Karmali I, Greer RD, Nuzzolo-
Page 723 and 724:
1673. Kelly AB, Garnett MS, Attwood
Page 725 and 726:
1702. Kielinen M, Linna SL and Moil
Page 727 and 728:
1731. Klin A, Lin DJ, Gorrindo P, e
Page 729 and 730:
1761. Koegel RL and Frea WD. Treatm
Page 731 and 732:
1790. Kolmen BK, Feldman HM, Handen
Page 733 and 734:
1819. Kratochvil CJ, Findling RL, M
Page 735 and 736:
1846. Lam MK and Rao N. Developing
Page 737 and 738:
1874. Lattimore LP, Parsons MB and
Page 739 and 740:
1903. Lee PC. Verification of a sim
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1932. Lerman DC, Vorndran C, Addiso
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1960. Licciardello CC, Harchik AE a
Page 745 and 746:
1989. Liptak GS, Orlando M, Yinglin
Page 747 and 748:
2015. Lorimer PA, Simpson RL, Myles
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2043. Luiselli JK, Kane A, Treml T,
Page 751 and 752:
2071. MacFarlane JR and Kanaya T. W
Page 753 and 754:
2099. Malone RP, Maislin G, Choudhu
Page 755 and 756:
2127. Marin FZ. CAM versus nucleopl
Page 757 and 758:
2157. Martineau J, Roux S, Adrien J
Page 759 and 760:
2185. Matson JL and Lo Vullo SV. A
Page 761 and 762:
2213. McCabe H. The Importance of P
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2240. McDougle CJ, Holmes JP, Carls
Page 765 and 766:
2267. McHale SM, Olley JG, Marcus L
Page 767 and 768:
2296. Merlo LJ, Lehmkuhl HD, Geffke
Page 769 and 770:
2325. Minderaa RB, Anderson GM, Vol
Page 771 and 772:
2354. Montgomery JM, Duncan CR and
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2385. Morrison RS, Sainato DM, Benc
Page 775 and 776:
2413. Munesue T, Ono Y, Mutoh K, et
Page 777 and 778:
2445. Napolitano DA, Tessing JL, Mc
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2474. Niederhofer H and Pittschiele
Page 781 and 782:
2501. Nwora AJ and Gee BM. A case s
Page 783 and 784:
2530. Olive ML, Lang RB and Davis T
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2559. Owens JA, Rosen CL and Mindel
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2589. Pansegrouw I and Alant E. Com
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2618. Paul C, Williams KE, Riegel K
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2646. Perry R, Nobler MS and Campbe
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2675. Piazza CC, Hagopian LP, Hughe
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2704. Poon L, Partika N and Bolman
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2734. Prizant BM. Speech-language p
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2764. Rapp JT, Vollmer TR, St. Pete
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2792. Reed P, Broomfield L, McHugh
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2819. Remington G, Sloman L, Konsta
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2849. Ringdahl JE, Kitsukawa K, And
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2877. Rogers SJ. Interventions that
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2908. Rossignol DA. Novel and emerg
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2939. Rutter M, Kreppner J, Croft C
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2967. Sandt D. Social Stories for S
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2994. Scanlon K. Art therapy with a
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3023. Schneider CK, Melmed RD, Bars
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3054. Schwartz IS, Sandall SR, Garf
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3085. Shafer MS, Egel AL and Neef N
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3115. Shipley-Benamou R, Lutzker JR
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3143. Siller M and Sigman M. The be
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3173. Smith C, Felce D, Jones E, et
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3202. Snyder A, Bossomaier T and Mi
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3230. Spero MH. The emancipation of
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3259. Stephens CE. Spontaneous imit
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3289. Strambi M, Longini M, Hayek J
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3318. Suzumura K. How an autistic b
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3346. Tager-Flusberg H and Calkins
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3376. Taylor I, O’Reilly M and La
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3407. Thunberg G, Ahlsen E and Sand
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3435. Trembath D, Balandin S, Toghe
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3464. Turner-Brown LM, Perry TD, Di
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3492. Van Der Putt R, Dineen C, Jan
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3522. Vitiello B. Recent NIMH clini
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3553. Walenski M, Mostofsky SH, Gid
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3581. Weber RC and Thorpe J. Teachi
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3610. Wheeler JJ, Baggett BA, Fox J
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3637. Williams B. Mental handicap n
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3669. Wimpory D, Chadwick P and Nas
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3698. Worth S and Reynolds S. The A
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3728. Young JM, Krantz PJ, McClanna
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3759. Zuddas A, Di Martino A, Mugli
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Appendix F. Approach to Categorizin
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APPENDIX G. Discussion of Recent Sy
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one a casein free regime. Diets wer
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outcome data as Type 6, defined as
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Yes—no disclosures to make G7 Bai
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Table G1. Characteristics of recent
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Random assignment Appropriate compa
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Study Group design Random assignmen
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APPENDIX I. Applicability Summary T
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Social skills (continued) Domain De
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Therapies for Children With Autism Spectrum Disorders

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