Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Bibby et al., 2002 Parent-managed
Country: behavioral intervention
UK
patterned after UCLA
Practice workshop model
setting:
Groups:
Academic G1: intervention
Intervention G1a: children with an
setting:
early (before or within 3
Home
Enrollment
period:
September 1998
to May 2000
Funding:
Autism and
Developmental
Disorders
Education
Research Ltd.
Author industry
relationship
disclosures:
NR
Design:
Prospective case
series
months of intervention
start) IQ score
G1b: children with an
early (before or within 3
months of intervention
start) VABS
G1c: children at a
minimum age of 72
months after at least 24
months behavioral
intervention
Assessments:
Conducted by seven
psychology graduates
with ≥ 12 months postgraduate
experience
working with children with
autism with same age
range as groups
IQ scores (assessed by
primary assessors,
research assistants, third
author and psychologist),
Bayley Scales of Infant
Development (2 nd ed.),
WPPSI-R, WISC-III,
Reynell Developmental
Language Scales (3 rd Inclusion criteria: Overall ratings: Overall ratings:
• Children with autism Sum pathology Sum pathology
whose parents who score, early, mean score, 12 months,
sought legal advice from points:
mean points:
the first author
G1: 4.9
G1: 2.2
concerning public Social skills: G1/BL: P < 0.01
funding for behavioral VABS socialization Social skills:
interventions
score, mean: VABS socializa-
Exclusion criteria: G1: 62.8
tion score, 12
• Unable to arrange for VABS socialization, months, mean:
assessment
developmental age, G1: 65.9
• Additional diagnosis of months:
G1/BL: P = NS
cerebral palsy
G1: 26.3
VABS socializa-
• Rett’s disorder Communication/ tion, 12 months,
Age, mean months ± SD: language: developmental
Study entry:
VABS communica- age, months:
G1a: 43.4 ± 12.6 tion score, mean: G1: 36.2
Follow-up:
G1: 66.9
G1/BL: P < 0.01
G1c: 85.5 ± 11.7 VABS communica- Communication/
Mental age, months: tion, developmental language:
G1a: 21.3 (n=17) age, months: VABS communi-
Gender, n:
G1: 35.2
cation score, 12
Male: 55
Reynell develop- months, mean:
Female: 11
mental language G1: 70.3
Race/ethnicity:
scale, months: G1c: 66.3
NR
Comprehension: G1/BL: P < 0.05
SES:
G1: 31.9
VABS communi-
Maternal education: NR Expressive: cation, 12 months,
Household income: NR G1: 31.2
developmental
Diagnostic approach: Adaptive behavior: age, months:
Referral
VABS composite G1: 47.5
Diagnostic tool/method: score, early, mean: G1c: 63.0
NR
G1b: 54.5
G1/BL: P < 0.01
Diagnostic category, n VABS composite Reynell develop-
(%):
score, mean: mental language
Autism: 58
G1: 58.8
scale, 12 months,
EK PDD-NOS: 2
VABS composite, months:
ed.), VABS (survey form Aspergers: 0
developmental age, Comprehension:
from Interview Edition
months:
G1: 37.5
(assessed by trained Other characteristics:
rater), ADI-R (assessed Age at beginning of
by research assistants) treatment, months ± SD:
Provider:
45.0 ± 11.2
Parent-managed Duration of behavioral
approach with care treatment at time of study
provided by consultants, entry, n (%):
family members, and < 12 months: 11 (18)
volunteers (19-20% UCLA 12-24 months: 31 (52)
Level II, 29-35% PhD or > 24 months: 18 (30)
registered clinical psy-
G1: 31.8
G1/BL: P < 0.01
VABS daily living Expressive:
score, mean: G1: 35.7
G1: 59.0
G1/BL: P < 0.01
VABS daily living, Adaptive
developmental age, behavior:
months:
VABS composite
G1:33.7
scores, 12
months, mean:
G1: 61.0
G1b: 63.4
chologist level without
G1c: 55.2
meeting UCLA criteria,
47-51% MA or BA level
paraprofessionals)
G1/BL: P = NS
Bibby et al., 2002 Measure of treatment Secondary diagnoses of VABS maladaptive VABS composite,
(continued) fidelity reported: additional neurological behavior score, 12 months,
No
disorders or epilepsy, n: 0 mean:
developmental
C-366