Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Social skills: Overall ratings:
Mousain-Bosc et Mg-vitamin B6 regimen: • Clinical symptoms of DSM-IV visual Improvement for
al., 2006 (6 mg/kg/day Mg, 0.6 PDD as described in contact score, mean ¾ groups of
Country: mg/kg/d vitamin B6) for an DSM-IV (G1)
± SD:
symptoms, n:
France
average of 8 ± 5 months Exclusion criteria: See G1: 3.33 ± 0.89 G1: 20/30
Practice (range 2-40 months) inclusion criteria
DSM-IV visual Social skills:
setting:
Assessments:
Age, years ± SD (range): contact score > 3, n: DSM-IV visual
Academic Symptoms and symptom G1: 4 ± 2 (1-10)
G1: 26
contact score,
Intervention groups of PDD from the Mental age:
DSM-IV connection mean ± SD:
setting:
DSM-IV evaluated by the NR
with equals score, G1: 1.36 ± 1.19
Clinic
physician after discussion Gender, n:
mean ± SD: DSM-IV visual
Enrollment with parents and teachers Male:
G1: 3.12 ± 0.74 contact score > 3,
period:
Biological parameters G1: 21
DSM-IV connection n:
NR
measured at first clinic
with equals score > G1: 6
Funding: visit of child then after 2 Female:
3, n:
DSM-IV
Sanofi-Aventis months of treatment; G1: 12
G1: 28
connection with
Author industry subsequent evaluations Race/ethnicity:
DSM-IV delight equals score,
relationship depended on the NR
partition score, mean ± SD:
disclosures: frequency of visits. SES:
mean ± SD: G1: 1.51 ± 1.00
NR
Children were followed Maternal education: NR G1: 3.03 ± 0.81 DSM-IV
Design: over a period of about Household income: NR DSM-IV delight connection with
Prospective case 24 months
Diagnostic approach: partition score > 3, equals score > 3,
series
Groups:
In Study
n:
n:
G1: Mg-B6 therapy Diagnostic tool/method: G1: 25
G1: 6
Co-interventions held DSM-IV
DSM-IV social DSM-IV delight
stable during treatment: Diagnostic category, n reciprocity score, partition score,
Yes
(%):
mean ± SD: mean ± SD:
Frequency of contact PDD:
G1: 3.30 ± 0.68 G1: 1.54 ± 1.06
during study:
G1: 33 (100)
DSM-IV social DSM-IV delight
NR
Other characteristics: reciprocity score > partition score >
Concomitant therapies, NR
3, n:
3, n:
n (%):
G1: 29
G1: 6
G1: 0
DSM-IV social DSM-IV social
interactions total reciprocity score,
N at enrollment:
score, mean ± SD: mean ± SD:
G1: 33
G1: 12.61 ± 3.01 G1: 1.51 ± 1.06
N at follow-up:
Communication/ DSM-IV social
G1: 33
language: reciprocity score >
DSM-IV delayed 3, n:
communication G1: 6
score, mean ± SD: DSM-IV social
G1: 3.39 ± 0.50 interactions total
DSM-IV delayed score, mean ±
communication SD:
score > 3, n: G1: 5.94 ± 4.10
G1: 33
G1/BL: P =
DSM-IV no
communication
score, mean ± SD:
G1: 3.09 ± 0.72
0.0000
C-287