Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion
Description Intervention
Criteria/Population
total ADOS score 11-17 G2b: 33 (24-40)
(young high functioning) G2c: 64 (54-71)
Gb: aged 24-47 months; G2d: 67 (54-71)
total ADOS score 18-24 Mental age:
(young low functioning) NR
Gc: aged 48-71 months; Gender, n (%):
total ADOS score 11-17 Male:
(older high functioning) G1: 13 (93)
Gd: aged 48-71 months; G1a: 4 (100)
total ADOS score 18-24 G1b: 3 (100)
(older low functioning) G1c: 4 (100)
Provider:
G1d: 3 (75)
Parent training by G2: 12 (86)
therapist
G2a: 4 (100)
Measure of treatment G2b: 2 (66)
fidelity reported: G2c: 3 (100)
No
G2d: 3 (75)
Aldred et al., 2004
(continued)
Co-interventions held
stable during treatment:
NR
Concomitant therapies:
NR
N at enrollment:
G1: 14
G1a: 4
G1b: 3
G1c: 4
G1d: 3
G2: 14
G2a: 4
G2b: 3
G2c: 4
G2d: 3
N at follow-up:
G1: 14
G1a: 4
G1b: 3
G1c: 4
G1d: 3
G2: 14
G2a: 4
G2b: 3
G2c: 4
G2d: 3
Female:
G1: 1 (7)
G1a: 0
G1b: 0
G1c: 0
G1d: 1 (25)
G2: 2 (14)
G2a: 0
G2b: 1 (33)
G2c: 0
G2d: 1 (25)
Race/ethnicity, mothers,
n:
African-Caribbean: 2
Caucasian: 26
SES:
Maternal education,
median years (range): 16.5
(16-21)
Paternal education,
median years (range): 17.6
(16-21)
Household income: NR
Diagnostic approach:
Clinician/self referral and
in study
Diagnostic tool/method:
ADI
Diagnostic category, n
(%):
Autism: 28 (100)
Other characteristics:
NR
Comments: *Standard deviations (as reported in paper) appear to be in error.
Author:
Chez et al.,
Intervention: 12 week
open-label study with
Inclusion criteria:
Based on diagnosis of
C-333
Baseline
Measures Outcomes
G2c: 14 ± 3.3 SD:
G2d: 20 ± 1.3 G1: 36.9 ± 21.2
Communication/ G2: 28.7 ± 16.6
language: G1/G2: P = NS
MCDI, raw score, Parent-child
mean ± SD: interaction codes,
Language mean frequency ±
comprehension: SD:
G1: 71.7 ± 2383* Parent synchrony:
G2: 95.4 ± 426* G1: 65.1 ± 14.3
Expressive G2: 49.5 ± 18.9
language:
G1/G2: P = 0.016
G1: 28 ± 467* Parent
G2: 25.6 ± 683* asynchrony:
Adaptive behavior: G1: 32.6 ± 14.3
VABS communi- G2: 50.5 ± 18.8
cation, mean ± SD:
G1: 22.6 ± 13.3
G2: 20.0 ± 10.8
G1/G2: P = 0.009
Parent-child
interaction codes,
mean frequency ±
SD:
Parent synchrony:
G1: 57.8 ± 15
G2: 57.1 ± 49.5
Parent asynchrony:
G1: 39.7 ± 16.1
G2: 42.9 ± 16.1
Child communication
acts:
G1: 30.8 ± 10.2
G2: 30.1 ± 11.1
Parent communication
acts:
G1: 66.3 ± 11.8
G2: 70.7 ± 11
Child shared
attention:
G1: 72 ± 23.6
G2: 62.8 ± 24.5
Parent shared
attention
G1: 93.5 ± 5.3
G2: 81.3 ± 22.3
Overall ratings:
CARS, mean ± SD:
Child communication
acts:
G1: 37.6 ± 10.1
G2: 27.6 ± 16.5
G1/G2: P = 0.041
Parent communication
acts:
G1: 64.4 ± 13
G2: 72.4 ± 16.5
G1/G2: P = 0.293
Child shared
attention:
G1: 77.6 ± 17.8
G2: 62.6 ± 32.7
G1/G2: P = 0.204
Parent shared
attention:
G1: 88.6 ± 8.7
G2: 80.3 ± 30.1
G1/G2: P = 0.176
Harms:
NR
Modifiers:
NR
Changes from
baseline to 12