Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD (continued)
Study
Inclusion/ Exclusion
Description
Anan et al., 2008
(continued)
Intervention
Criteria/ Population
Author:
Andersen et al.,
2008
Country:
US
Practice
setting:
Academic
Intervention
setting:
Intervention:
Melatonin given 30
minutes to one hour
before bedtime
Children under 6 started
on 0.75-1 mg and
increased by 1 mg every
2 weeks up to 3 mg if no
response at lower dose
Children 6 and older
Inclusion criteria:
• Clinical diagnosis of
ASD based on DSM-IV
criteria
• Confirmed use of
supplemental melatonin
for sleep concerns
based on medication
records at follow-up
clinical visits
C-134
Baseline
Measures Outcomes
Visual reception: Motor skills:
G1: 20.90 ± 6.52 MSEL fine motor
Fine motor: score, mean ±
G1: 21.44 ± 5.30 SD:
Receptive language: G1: 65.29 ± 18.97
G1: 13.39 ± 7.17 G1/BL: P < 0.001
Expressive VABS motor skills
language:
score, mean ±
G1: 12.21 ± 7.12 SD:
VABS develop- G1: 70.06 ± 16.20
mental age, months G1/BL: P < 0.001
± SD:
Educational/
Composite: cognitive/
G1: 15.91 ± 3.60 academic
Communication: attainment:
G1: 11.90 ± 4.71 MSEL develop-
Socialization: mental age,
G1: 10.30 ± 2.56 months ± SD:
Daily living skills: Composite:
G1: 17.86 ± 3.96 G1: 25.20 ± 7.93
Motor skills: Visual reception:
G1: 23.57 ± 6.20 G1: 29.51 ± 7.61
Fine motor:
G1: 28.46 ± 8.81
Receptive
language:
G1: 21.85 ± 10.22
Expressive
language:
G1: 21.00 ± 10.36
VABS developmental
age,
months ± SD:
Composite:
G1: 21.65 ± 5.71
Communication:
G1: 17.87 ± 6.37
Socialization:
G1: 15.75 ± 4.83
Daily living skills:
G1: 21.68 ± 5.67
Motor skills:
G1: 30.99 ± 9.41
Harms:
NR
Modifiers:
NR
Overall ratings: Overall ratings:
Sleep complaints, Quality of sleep, n
%:
(%):
Sleep-onset No longer
insomnia only: 23 reported sleep
Sleep-maintenance concerns: 27 (25)
insomnia only: 8 Improved sleep,
Both sleep-onset but still some
and sleep- concerns in
maintenance follow-up visits: 64