Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Communication/ Communication/
McConachie et al., More Than Words course • Child Identified by the language: language:
2005
to improve parents’ skills local community MCDI total speech MCDI total
Country: in social interaction with pediatrician or speech production score, speech production
UK
child and improve
and language therapist mean ± SD: score, mean ±
Practice communication with child as having language G1a: 34.65 ± 62.74 SD:
setting:
The More Than Words delay and some aspect G1b: 188.22 ± G1a: 72.6 ±
Academic course lasted 3 months of concern about social 159.18
100.07
Intervention with weekly group
behavior that raised the G2a: 30.75 ± 54.35 G1b: 271.38 ±
setting:
instruction sessions suspicion of ASD G2b: 77.54 ± 79.22 148.43
Home
(totaling 20 hours) and 3 • Age 24-48 months Social Skills: G2a: 38.92 ±
Enrollment home visits for individual • Parents agreed to attend ADOS reciprocal 54.89
period:
discussion/feedback More than Words course social interaction G2b: 131.54 ±
NR
Interval between assess- Exclusion criteria: and communication 114.7
Funding: ments, months ± SD: • Serious organic medical score, mean ± SD: G1a/BL: P < 0.05
Community Fund G1: 8.65 ± 1.50
disorder
G1a: 17.35 ± 2.45 G1b/BL: P < 0.05
(National Lottery G2: 5.16 ± 1.31
• About to start an G1b: 4.33 ± 2.78 G2a/BL: P < 0.05
Charities Board), Assessments:
intensive home program G2a: 17.17 ± 3.76 G2b/BL: P < 0.05
The NHS Pre-treatment and at 7 Age, months ± SD: G2b: 7.15 ± 5.24 G2a/G1a: P =
Executive R&D months: VABS, MCDI, G1: 38.12 ± 6.54 Problem behavior: 0.019
Northern and ADI-R, ADOS, BSQ G2: 34.96 ± 6.68 BSQ score, mean ± G2b/G2a: P <
Yorkshire Region assessments conducted Mental age:
SD:
0.001
(for training course in home by study NR
G1a: 11.59 ± 4.70 Social skills:
leaders)
psychologist; Joy and Fun Gender, n (%):
G1b: 9.33 ± 4.21 ADOS reciprocal
Author industry assessment (unpublished Male:
G2a: 12.42 ± 3.94 social interaction
relationship checklist created for study G1: 21 (81)
G2b: 9.31 ± 3.71 and communica-
disclosures: to document positive G2: 21 (84)
Joy and Fun tion score, mean
NR
parent strategies), QRS- Female:
assessment score, ± SD:
Design: F, PFQ by parents G1: 25 (19)
mean ± SD G1a: 14.82 ± 6.47
Non randomized Groups:
G2: 4 (16)
G1a: 11.18 ± 4.30 G1b: 6.00 ± 3.87
controlled trial G1: More Than Words Race/ethnicity:
G1b: 10.89 ± 2.98 G2a: 14.00 ± 6.45
G2: waitlist control NR
G2a: 10.83 ± 3.86 G2b: 7.69 ± 5.84
Ga: autism diagnosis SES:
G2b: 12.85 ± 3.91 G1a/BL: P = NS
Gb: NCA diagnosis Maternal education: NR Adapted QRS-F G1b/BL: P = NS
Provider:
Household income: NR score, mean ± SD: G2a/BL: P = NS
Developmental psycho- Diagnostic approach: G1a: 19.53 ± 9.50 G2b/BL: P = NS
logist (second author) Referral, confirmed in G1b: 18.44 ± 9.88 G2a/G1a: P = NS
Measure of treatment Study
G2a: 19.60 ± 5.32 G2b/G2a: P = NS
fidelity reported: Diagnostic tool/method: G2b: 15.08 ± 8.63 Problem
Yes
ADOS
Parent Feelings behavior:
Co-interventions held Diagnostic category, n Questionnaire BSQ score, mean
stable during treatment: (%):
score, mean ± SD: ± SD:
Yes
Autism:
G1a: 145.00 ± 20.40 G1a: 12.50 ± 5.05
Concomitant therapies, G1: 17 (65)
G1b: 150.33 ± G1b: 8.44 ± 3.40
n (%):
G2: 12 (48)
26.06
G2a: 12.92 ± 4.10
G1: 17 (65.4)
NCA:
G2a: 146.36 ± 18.35 G2b: 9.23 ± 3.98
G2: 16 (61.5)
G1: 9 (35)
G2b: 159.31 ± G1a/BL: P = NS
G2: 13 (52)
22.36
G1b/BL: P = NS
G2a/BL: P = NS
G2b/BL: P = NS
G2a/G1a: P = NS
G2b/G2a: P = NS
McConachie et al., N at enrollment: Other characteristics:
Joy and Fun
2005 (continued) G1: 26
VABS composite score,
assessment
G1a: 17
mean ± SD:
score, mean ±
G1b: 9
G1: 66.42 ± 11.44
SD:
G2: 21
G2: 67.76 ± 9.81
G1a: 13.94 ± 4.68
C-317