Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD (continued)
Study
Inclusion/ Exclusion Baseline
Description Intervention
Criteria/ Population Measures Outcomes
Cure Autism Now positive reinforcement, stable dose of
mean ± SD (range): (1-4)
Foundation, NIH and using communication psychiatric medication G1: 56.66 ± 16.84 G2: 4.77 ± 0.81
Author industry skills to encourage • If medication was being (20-77)
(3-6)
relationship independence in daily used, children
G2: 54.69 ± 16.8 G1/G2: P <
disclosures: routines
maintained the same (25-85)
0.0001
None
Schedule: 16 weekly dose throughout the
Parent MASC
Design: sessions each lasting study
score, mean ± SD
RCT
90 minutes (30 minutes Exclusion criteria:
(range):
Note:
with child; 60 minutes • Verbal IQ less than 70
G1: 58.48 ± 14.72
See follow-up with parents)
• Currently in
paper with Assessments:
psychotherapy or social
additional Trained graduate student skills training, or was
participants, Wood independent evaluators receiving behavioral
et al., 2009 who were blind to the interventions such as
({#5523}) intervention condition of applied behavior
each family conducted analysis
diagnostic interviews • Family was currently in
before and immediately family therapy or a
after intervention or parenting class
waitlist (ADIS-C/P); • Child began psychiatric
MASC, CGI-I
medication or changed
Measures were com- dose during intervention
pleted over the course of
• The child or parents
two days; post-treatment
appeared unable to
assessments were
participate in the
completed on the final day
intervention program for
of treatment or within a
any reason
week of termination; post- Age, years ± SD:
waitlist assessments were G1: 9.18 ± 1.42
conducted three months G2: 9.22 ± 1.57
after the baseline assess- Mental age:
ment but before initiating
NR
CBT (readministering all Gender, n (%):
anxiety measures)
Male:
Groups:
G1: 12 (71)
G1: CBT program
G2: 15 (65)
G2: waitlist
Female:
G1: 5 (29)
G2: 8 (35)
(40-98)
G2: 76.57 ± 14.65
(56-103)
G1/G2: P <
0.0001
Child MASC
score, mean ± SD
(range):
G1: 46.93 ± 14.76
(27-72)
G2: 46.5 ± 15.83
(22-79)
G1/G2: P = 0.87
Harms:
NR
Modifiers:
NR
Wood et al., 2009 Provider:
Race/ethnicity, n (%):
(continued) Doctoral students in G1:
clinical or educational Caucasian:
psychology and doctoral- G1: 8 (47)
level psychologists G2: 11 (48)
Measure of treatment Latino/Latina:
fidelity reported: G1: 2 (12)
Yes
G2: 3 (13)
Co-interventions held Asian/Pacific Islander:
stable during treatment: G1: 4 (23)
See inclusion/exclusion G2: 2 (9)
criteria
African American:
Concomitant therapies: G1: 0
Psychiatric medication: G2: 1 (4)
SSRI:
Asian/Caucasian:
G1: 2 (12)
G1: 1 (6)
G2: 3 (13)
G2: 1 (4)
Atypical antipsychotic: Asian/Latino:
C-108