Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion
Description Intervention
Criteria/Population
Childhood disintegrative
disorder:
G1: 1 (2.5)
G2: 0
PDD-NOS:
G1: 7 (17.5)
G2: 4 (10.3)
Other characteristics:
Weight, kg ± SD:
G1: 31.2 ± 14.5
G2: 27.6 ± 8.6
VABS composite score,
mean ± SE:
G1: 46.6 ± 13.1
G1a: 44.6 ± 13.8†
G2: 52.2 ± 19.8
G2a: 46.7 ± 19.7†
CARS score, mean ± SE:
G1: 38.9 ± 5.3
G1a: 40.1 ± 5.4†
G2: 39.1 ± 6.7
G2a: 50.9 ± 6.6†
CARS score, n (%):
31-36, mild/moderate:
G1: 17 (42.5)
G2: 18 (46.2)
37-60, severe:
G1: 23 (57.5)
G2: 21 (53.8)
Shea et al., 2004
(continued)
C-231
Baseline
Measures Outcomes
(n=7)
G1a: 8.7 ± 3.3
Obsessive/ (n=25)
repetitive:
G2a: 6.9 ± 2.9
G1a: 86.3 ± 19.4 (n=26)
(n=7)
G1a/G2a: P =
G2a: 98 ± 0 0.072
(n=7)
Conduct problem:
Tantrums/negative G1a: 6.5 ± 5.7
mood:
(n=26)
G1a: 80.8 ± 10.1 G2a: 15.5 ± 11.9
(n=7)
G1a/G2a: P =
G2a: 81.2 ± 13.9 0.005
(n=7)
Hyperactive:
Medical:
G1a: 9.4 ± 5.4
Pulse, mean bpm ± (n=25)
SD:
G2a: 14.9 ± 8.4
G1: 90.2 ± 12.0 G1a/G2a: P =
G2: 95.0 ± 13.7 0.021
Diastolic BP, mean Insecure/anxious:
mm Hg ± SD: G1a: 3.2 ± 4.3
G1: 68.1 ± 9.8 (n=26)
G2: 67.8 ± 10.3 G2a: 5.4 ± 4.8
Systolic BP, mean G1a/G2a: P = NS
mm Hg ± SD: Overly sensitive:
G1: 99.8 ± 9.6 G1a: 2.8 ± 2.3
G2: 100.4 ± 10.5 (n=26)
Weight, mean kg ± G2a: 4.3 ± 3.3
SD:
G1a/G2a: P =
G1: 31.2 ± 14.5 0.029
G2: 27.5 ± 8.7 Self-injury/
stereotypic:
G1a: 2.2 ± 3.1
(n=26)
G2a: 2.8 ± 3.9
G1a/G2a: P = NS
Self-isolated/
ritualistic:
G1a: 2.4 ± 2.5
(n=26)
G2a: 4.5 ± 5.5
G1a/G2a: P =
0.078
VAS-MS, mean
change ± SD:
G1: -38.4 ± 28.9
G2: -26.2 ± 29.2
G1/G2: P ≤ 0.05
VAS-MS score by
symptom, mean ±
SD:†
Aggression:
G1a: 22.3 ± 20
(n=7)
G2a: 63.4 ± 37.3
(n=8)
G1a/G2a: P =
0.056