Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion
Description Intervention
Criteria/Population
2004
Rivastigmine tartarate ASD or PDD-NOS per
Country:
DSM-IV
US
At BL, 0.2 ml (0.4 mg) of Exclusion criteria:
rivastigmine tartarate See inclusion criteria
Practice given twice daily in a Age, mean/yrs (range):
setting: Specialty liquid suspension 6.91 (2.85-12)
treatment center (2mg.ml). If any adverse Mental age: NR
event, dosage was Gender:
halved or discontinued. M, n (%): 24 (75)
If no improvement after 2 F, n (%): 8 (25)
wks of starting on the
medicaton, dosage was Race/ethnicity:
doubled to 0.4 ml (0.8mg) NR
twice daily
SES:
Maternal education: NR
Intervention
setting: Clinic
Enrollment
period:
Month : NR
Funding:
NR
Author industry
relationship
disclosures:
NR
Design:
Prospective case
series
Maximum daily dose was
0.4 ml (0.8mg) twice daily
Assessments:
Expressive One Word
Vocabulary Test,
Childhood Autism Rating
Scale administered by
study coordinator at
baseline, 6wks and 12
wks. Conners’ Parent
Rating Scale completed
by parents at baseline,
6wks, 12 wks.
Groups:
Other characteristics, n
G1: Rivastigmine (%):
tartarate
Previous diagnosis of
Co-interventions held nocturnal epileptiform EEG
stable during treatment: abnormalities: 13 (40.6)
NR
Frequency of contact
during study: Testing at
Baseline, 6 weeks, 12
weeks. Nurses contacted
parents weekly to check
for any concerns.
Concomitant therapies,
n:
Anticonvulsants: 21
CNS stimulants: 8
Adrenergic blockers: 4
Antipsychotics: 2
Antidepressants: 1
Corticosteroids: 1
N at enrollment:
G1: 32
Household income: NR
Diagnostic approach:
In Study/Referral
Diagnostic tool/method:
DSM-IV
Diagnostic category, n
(%):
Autism: 11 (34.4)
PDD-NOS : 21 (65.6)
C-334
Baseline
Measures Outcomes
34 ± 6.36
weeks:
Overall ratings:
CARS, mean ±
SD: 30.84 ± 8.71
P = 0.001
Communication/
language:
Expressive one-word
Picture vocabulary
test, mean ± SD:
34.91 ± 33.61
Receptive One-word
Picture Vocabulary
test, mean ± SD:
37.78 ± 29.70
Problem behavior:
Conner’s parent
rating scale, mean ±
SD: 34.5 ± 12.30
Communication/
language:
Expressive oneword
Picture
vocabulary test ,
mean ± SD:
41.44 ± 36.74
P = 0.001
Receptive Oneword
Picture
Vocabulary test,
mean ± SD:
39.53 ± 32.47
P = NS
Problem
behavior:
Conner’s parent
rating scale,
mean ± SD: 28.28
± 13.53
P = 0.005
Harms:
NR
Modifiers:
NR