Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Inclusion/Exclusion Baseline
Description Intervention
Criteria/Population Measures Outcomes
Author:
Intervention:
Inclusion criteria: Educational/ Educational/
Beglinger et al., Intensive behavioral • Diagnosis of autism by cognitive/ cognitive/
2005
treatment based on the a licensed psychologist academic academic
Country: UCLA model for 0-44 or psychiatrist, using the attainment: attainment:
US
months for children Autism Diagnostic IQ, mean ± SD IQ, mean ± SD:
enrolled in Multisite Interview and DSM-IV (range):
G1a: 54.5 ± 13.5
Practice Young Autism Project Criteria
54.13 ± 12.63 (32- G1b: 76.8 ± 13.4
setting:
Academic
(MYAP)
• chronological age of not 82)
more than 42 months at
G1c: 80.8 ± 15.2
G1d: 93.8 ± 10.1
40 hrs /wk of one-to-one referral and not more IQ scores by Scale,
Intervention Intervention, initially than 8 years at the time mean ± SD:
setting:
extremely individualized of enrollment into this G1a: 50.6 ± 13.4
Home
discrete trial training to study
G1b: 62.4 ± 11.9
the child, later becoming • acceptance into the G1c: 42.4 ± 12.7
Enrollment complex, group-setting MYAP and active G1d: 55.8 ± 12.1
period:
focused and adapted to participation in intensive
NR
the child’s environment. treatment
Funding:
(approximately 30–40 h
Washington State Assessments:
per week) of one to-one
University Participants administered instruction
core assessment tests at • no major medical
Author industry time of intake and
limitations that would
relationship annually thereafter
impede treatment (such
disclosures: (excluding WSQ, except as cerebral palsy or
NR
in a small sub-sample); if motor deficits)
children showed
• ratio IQ of 30 or higher
Design: improvements in
on the Bayley Scales of
Prospective case functioning, the Bayley Infant Development:
series
was replaced with the Mental Development
WPPSI-R
Index
Exclusion criteria:
Groups (4 subtypes of See Inclusion criteria
autism based on social Age, mean/yrs ± SD
style):
(range):
G1a: Aloof
5.42 ± 1.08 (3-6)
G1b: Passive
Change in IQ in
G1a was
significantly
smaller than in
G1c (P< 0.05)
and G1d (P <
0.0001)
G1a subtype has
the lowest
functioning
children followed
by G1b, G1c and
G1d at the highest
end.
WSQ summary
score by Scale,
mean ± SD:
G1a: 29.1 ± 14.5
G1b: 33.5 ± 10.8
G1c: 28.2 ±10.3
G1d: 33.7 ± 15.5
None of WSQ
scores were
G1c: Active-but-odd Mental age:
G1d: Typically developing NR
Gender:
Provider:
M, n (%): 32 (86.5)
A team of project director, F, n (%): 5 (13.5)
supervisor, lead therapist,
correlated with
either age or
months in
treatment.
Pearson values
ranged from 0.19
student therapists and
parents
Race/ethnicity:
NR
to -0.14.
Pre Tx IQ
Measure of treatment
fidelity reported:
No
SES:
Maternal education: NR
significantly
correlated with
WSQ summary
Co-interventions held
Household income: NR
score for G1a &
G1d (P < 0.05)
stable during treatment: Diagnostic approach:
NR
Referral
and is correlated
with Current IQ (P
= 0.001)
Concomitant therapies:
NR
C-298
Harms:
NR