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Therapies for Children With Autism Spectrum Disorders

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Evidence Table. <strong>Therapies</strong> <strong>for</strong> children with ASD (continued)<br />

Study<br />

Description Intervention<br />

Aman et al., 2005<br />

McDougle et al.,<br />

2005^<br />

Arnold et al.,<br />

2003†<br />

RUPP, 2002‡<br />

Williams et al,<br />

2006º<br />

Anderson et al.,<br />

2007ª<br />

Aman et al., 2008§<br />

Martin et al.,<br />

2004¥<br />

(continued)<br />

Inclusion/ Exclusion<br />

Criteria/ Population<br />

C-131<br />

Baseline<br />

Measures Outcomes<br />

G1: 35.1<br />

Dizziness/loss of<br />

balance:<br />

Mild:<br />

G1: 13.5<br />

Moderate/severe:<br />

G1: 2.7<br />

Tachycardia:<br />

Mild:<br />

G1: 10.8<br />

Muscles appear<br />

stuck:<br />

Mild:<br />

G1: 5.4<br />

Moderate/severe:<br />

G1: 2.7<br />

Tongue<br />

movements:<br />

Mild:<br />

G1: 2.7<br />

AEs, pre-extension<br />

phase, %:<br />

Excessive<br />

appetite:<br />

G1: 54.0<br />

Enuresis:<br />

G1: 41.3<br />

Tired during day:<br />

G1: 22.2<br />

Dry mouth:<br />

G1: 20.6<br />

Coughing:<br />

G1: 19.0<br />

Anxiety:<br />

G1: 19.0<br />

Rhinitis:<br />

G1: 15.9<br />

Excess saliva: G1:<br />

12.7<br />

Nausea/vomiting:<br />

G1: 6.3<br />

Difficulty falling<br />

asleep:<br />

G1: 6.3<br />

Gynecomastia:<br />

G1: 3.2<br />

Difficulty waking:<br />

G1: 4.8<br />

Diarrhea:<br />

G1: 6.3<br />

Constipation:<br />

G1: 6.3<br />

Skin rash:<br />

G1: 1.6<br />

Muscles “stuck”:<br />

G1: 3.2<br />

AEs, extension

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