Therapies for Children With Autism Spectrum Disorders

Evidence Table: Therapies for Children with ASD (continued)
Study
Inclusion/ Exclusion Baseline
Description Intervention
Criteria/ Population Measures Outcomes
2000
hrs/week for 2-3 years referral
academic academic
Country: from therapist, parent with • Residence within 1 hr of attainment: attainment:
US
therapist 5 hrs/week for UCLA center
Stanford Binet or Bayley Scales of
first 3 months
• IQ between 35-75 Bayley Scales of Infant
Practice
• Diagnosis of ASD or Infant Development- Developmentsetting:
Parent intervention, PDD-NOS
Mental Development Mental
Specialty families taught techniques • Absence of major Index (scored as Development
treatment center from Lovaas manual 2 medical problems IQ), mean ± SD: Index (scored as
sessions/week in homes Exclusion criteria: G1: 50.53 ± 11.18 IQ), mean ± SD:
Intervention for 3-9 months
• See inclusion criteria G2: 50.69 ± 13.88 G1: 66.49 ± 24.08
setting: Clinic,
Age, mean/months ± SD:
G2: 49.67 ± 19.74
Home
Assessments:
At Intake:
Merrill-Palmer Scale P < 0.05
Enrollment Once intake assessments G1: 36.07 ± 6.00 of Mental Tests,
period:
had been completed on 4- G2: 35.77 ± 5.37 mean ± SD: Merrill-Palmer
1989 to 1992 8 children, they were Follow-up:
G1: 21.60 ± 4.49 Scale of Mental
Funding: divided into 2 cohorts G1: 94.07 ± 13.17 G2: 21.92 ± 5.50 Tests, mean ±
Department of (autism & PDD); children G2: 92.23 ± 17.24
SD:
education & UCLA were paired by statistician Mental age:
Communication/ G1: 64.33 ± 18.74
Regents on IQ (Bayley), and then NR
language: G2: 49.17 ± 21.43
Author industry randomly assigned 1 Gender, n (%):
Reynell
P < 0.05
relationship member of each pair to M:
Development
disclosures: treatment or parent- G1:12 (80)
Language Scale Communication/
NR
training group
G2:11 (85)
Total, mean ± SD: language:
Design:
F:
G1: 28.60 ± 4.07 Reynell
RCT
Groups:
G1: 3 (20)
G2: 30.00 ± 6.34 Development
G1: intensive training G2: 2 (15)
Language Scale
G2: parental training
Comprehension, Total, mean ± SD:
mean ± SD: G1: 87.40 ± 46.21
G1: 13.47 ± 3.60 G2: 61.33 ± 31.88
G2: 13.69 ± 3.73 P < .05
Smith et al.
2000 (continued)
Provider:
Therapists in UCLA
Young Autism Project
Measure of treatment
fidelity reported:
Yes
Co-interventions held
stable during treatment:
NR
Concomitant therapies:
NR
N at enrollment:
G1: 15
G2: 13
N at follow-up:
G1: 15
G2: 13
Race/ethnicity, n (%):
White:
G1: 7 (47)
G2: 7 (54)
Hispanic:
G1: 4 (26)
G2: 2 (15)
Black:
G1: 1 (7)
G2: 3 (23)
Asian:
G1: 3 (20)
G2: 1 (8)
SES:
Maternal education,
median (range):
G1: 12 (10-16+)
G2: 15 (12-16+)
Paternal education, median
(range):
G1: 13-14 (