Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD (continued)
Study
Inclusion/ Exclusion
Description Intervention
Criteria/ Population
stable during treatment: a checklist regarding
Yes
circumscribed interests;
Concomitant therapies, review of previous
n:
assessment records
Psychiatric medication: Diagnostic category, n
NR
(%):
N at enrollment: Autism: 19 (100)
G1: 9
G2: 10
N at post-treatment
follow-up:
G1: 9
G2: 10
Other characteristics:
NR
Wood et al., 2009 N at 3-month follow-up:
(continued) G1: 4
G2: NA
Author:
Intervention:
Wood et al., 2009
Country:
US
Practice
setting:
Academic
Intervention
setting:
Clinic
Enrollment
period:
September 2004
to December 2007
Funding:
Building Confidence CBT
program (modified) –
includes coping skills
training followed by in vivo
exposure (facing fearful
situation repeatedly while
using coping skills and
remaining in situation until
habituation). Hierarchy of
fearful situations created
and the child moves
through the hierarchy.
Parent training involves
supporting in vivo,
Inclusion criteria:
• Met research criteria for
diagnosis of autism,
Asperger syndrome, or
PDD-NOS
• Met research criteria for
one of the following:
separation anxiety
disorder (SAD), social
phobia, or obsessive
compulsive disorder
(OCD)
• Not taking any
psychiatric medication at
baseline or were on a
C-107
Baseline
Measures Outcomes
G1: NR
G2: NR
G1/G2: P = 0.10
(favoring G1)
SRS autistic
mannerisms
score, mean:
G1: NR
G2: NR
G1/G2: P = NS
Commonly
occurring
comorbidities:
ADIS-CSR score,
mean ± SD (range):
G1: 5 ± 0.68 (4-6)
G2: 5.14 ± 0.56
(4-6)
Parent MASC score,
mean ± SD (range):
G1: 71.25 ± 17.07
(36-98)
G2: 75.38 ± 12.98
(56-103)
Child MASC score,
Communication/
language:
SRS social
communication
score, mean:
G1: NR
G2: NR
G1/G2: P < 0.05
(favoring G1)
Harms:
NR
Modifiers:
Post-treatment
SRS scores were
predicted by
ADIS-C/P
Clinician’s Rating
Scale change
scores and
baseline SRS
total scores (P <
0.01)
Post-treatment
ADIS-C/P scores
were predicted by
baseline ADIS-
C/P scores and
SRS change
scores (P < 0.01)
Overall ratings:
Meeting CGI
response criteria,
n (%):
G1: 13 (92.9)
G2: 2 (9.1)
G1/G2: P <
0.0001
Commonly
occurring comorbidities:
ADIS-CSR score,
mean ± SD
(range):
G1: 2.36 ± 1.15