Therapies for Children With Autism Spectrum Disorders

Evidence Table. Therapies for children with ASD
Study
Description Intervention
Mousain-Bosc et
al., 2006
(continued)
Inclusion/Exclusion
Criteria/Population
C-290
Baseline
Measures Outcomes
DSM-IV language
score, mean ±
SD:
G1: 1.90 ± 1.22
DSM-IV language
score > 3, n:
G1: 10
DSM-IV symbolic
games score,
mean ± SD:
G1: 1.66 ± 1.15
DSM-IV symbolic
games score > 3,
n:
G1: 9
DSM-IV abnormal
or delayed functioning
total score,
mean ± SD:
G1: 6.48 ± 3.77
G1/BL: P =
0.0000
DSM-IV abnormal
or delayed functioning
total score,
change > 5, n:
G1: 17/33
Medical:
Erc-Mg (mmol/L),
mean ± SD:**
G1: 2.42 ± 0.41
G1/BL: P =
0.0198
Erc-Mg increased,
post-treatment, n
(%):
G1: 11/17 (65)
i-Ca (mmol/L),
mean ± SD:
G1: 1.20 ± 0.05
G1/BL: P = NS
s-Mg (mmol/L),
mean ± SD:
G1: NR
G1/BL: P = NS
Harms:
NR
Modifiers:
NR
Comments: *data only illustrated graphically
** Authors report when Mg supply was stopped, Erc-Mg values returned to low levels in about 2 months
Author:
Nagaraj et al.,
2006
Country:
India
Intervention:
Liquid suspension
risperidone or placebo,
0.5 mg/day orally for two
Inclusion criteria: Overall Ratings:
• Age ≤ 12 years CARS score, median
• Diagnosed with autism (range):
according to DSM IV G1: 39.5 (32.5-46)
criteria
G2: 38.5 (31.5-43)
Overall Ratings:
CARS score,
median (range):
G1: 32.0 (24.5-
40.5)