Anais da 27º Semana Científica - Hospital de Clínicas de Porto Alegre

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Revista HCPA 2007; 27 (Supl.1)
good indicator of bad prognosis in invasive breast cancer. Then, cerbB2 status determination could help in the identification of the
ideal method for stratifying patients with breast cancer into prognostic and optimal therapeutic groups.
POST MENOPAUSE AND BREAST CANCER PROGNOSIS MARKERS
RENATA BRUTTI BERNI; CLAUDIO GALLEANO ZETTLER; VIRGÍNIA RIBAS; RAFAEL DA ROSS MOTTA;
EDUARDO CAMBRUZZI
Introdution: Many studies support that post -menopausal women have shown a better prognosis in breast cancer, expressing more
frequently the estrogen receptor (ER) compared to younger ones. The present study intend to determine if this statement occurs in
our institution, and if the patients' age has any influence on the result of needle biopsies correlated to surgery. Matherial/Methods:
Ninety needle biopsies of breast cancer patients performed at outpatient gynaecology-oncology clinic of Santa Rita Hospital,
Porto Alegre, RS were analised. This study was based on immunohistochemistry method though avidine biotin peroxidase
complex, using estrogen receptor (ER) marker. The data from the needle biopsy using markers were correlated to patients age and
to surgery. Results: Among 63 post-menopausal patients, 48 (76,1%) presented positive ER for both biopsy and tumor. Otherwise,
among the pre-menopausal ones, only 15 (55%) had this kind of result. The correlation between ER results for biopsy and tumor
was straight, and was not affect by patients age. Conclusion: Post-menopausal patients show higher positivity for ER than the
younger ones, a true statement in our casuistic, and patient's age doesn't influence the biopsy/surgery correlation.
RELATIONSHIP BETWEEN TUMOR SIZE AND ESTROGEN RECEPTORS IN NEEDLE BIOPSIES
RENATA BRUTTI BERNI; CLAUDIO GALLEANO ZETTLER; VIRGÍNIA RIBAS; RAFAEL DA ROSS MOTTA;
EDUARDO CAMBRUZZI
Introdution: Core needle biopsy configures an accurate assessment of a breast mass, because the larger core needle usually
removes enough tissue to evaluate abnormal cells. Besides, it has shown high diagnosis sensibility. But there's still some doubt if
the results of this method depends on the tumors' size. Matherial/Methods: We studied ninety needle biopsies of breast cancer
patients performed at outpatient gynaecology-oncology clinic of Santa Rita Hospital, Porto Alegre, RS. This study was based on
immunohistochemistry method though avidine biotin peroxidase complex, using estrogen receptor (ER) marker. The data from
the needle biopsy using markers were correlated to surgery. Results: Among the sixty one needle biopsies ER-positive, 70,5%
were pT2, 16,4% were pT3, 9,9% were pT1 and 3,2% were pT4. Among the remaning twenty-nine cases ER-negative, 58,6%
were pT2, 24,2% were pT1 and 17,2% pT3. The results of ER positivity for the entire tumor analisis were exactly the same.
Conclusions: The core biopsy is an accurate method for the evaluation of ER positivity independently of the tumor' size (p=0,05).
CORRELATION BETWEEN ESTROGEN RECEPTOR AND P53 EXPRESSION IN CORE BIOPSIES AND IN SURGICAL
SPECIMENS
RENATA BRUTTI BERNI; CLAUDIO GALLEANO ZETTLER; VIRGÍNIA RIBAS; RAFAEL DA ROSS MOTTA;
EDUARDO CAMBRUZZI
Introdution: Many factors have been reported to be able to predict the biological behavior and clinical outcome of breast cancer,
including tumor suppressor gene p53 and steroid receptors. The aim of the present study was to determine the possible
independent correlation between estrogen receptor(ER) and p53 expression in core needle biopsies and in surgical specimens.
Matherial/methods: The author studied ninety needle biopsies of breast cancer patients, which were performed at outpatient Santa
Rita’s gynecology-oncology clinic, Porto Alegre, Rio Grande do Sul. Patients had a media-age of 59,5 years at diagnosis. The
study was based on immunoistochemistry method through avidin biotin peroxidasis (ABC) complex, using the following markers:
estrogen receptor (ER) and p53 protein. The study was performed at FFFCMPA Pathology Department. The needle biopsy data
using markers was correlated to surgery. Results: Needle aspiration biopsy revealed a 100% sensitivity and specificity for ER. For
p53, the needle biopsies showed a 92,7% sensitivity and 89,7% specificity. Conclusion: The elevated sensitivity and specificity
found revealed the core needle biopsy utility for ER and p53 research in breast cancer.
CERB-B2 STATUS, TUMOR SIZE AND PROGNOSIS
RENATA BRUTTI BERNI; CLAUDIO GALLEANO ZETTLER; RAFAEL DA ROSS MOTTA; EDUARDO CAMBRUZZI
Introdution: Cerb-B2 amplification seems to predict relative resistence to therapy in estrogen-receptor positive women, and is
associated with a more aggressive phenotype. Our study intends to test if cerb-B2 shows a significant association with tumor size.
Matherial/methods: A review of forty cases of breast cancer was made in our institution between 2003 and 2007. Inclusion criteria
were patients with infiltrating ductal carcinoma in wich imunohistochemical study was performed, including axillar analyses. The
graduation score results (T1, T2,T3 and T4) were crossed with positive or negative cerb B2. Statiscal analyses was performed
using qui-square test. Results: In our study, C-erb B2 did not show any relationship with tumor size (pConclusion: Although size
of ductal carcinoma and cerb B2 positivity are known to be associated with a more aggressive clinical behavior, a larger tumor
didn't show a significant correlation with positive c-erb B2 in our analisis. This result contrasts with previous studies found in our
revision, maybe due the sample size.
IMMUNOHISTOCHEMICAL ANALYSIS OF TISSUE FACTOR EXPRESSION IN HUMAN COLORECTAL CARCINOMA:
CORRELATION WITH ANGIOGENESIS, CLINICOPATHOLOGICAL ASPECTS AND SURVIVAL
ROBERTO GUIDOTTI TONIETTO; VINICIUS DUVAL DA SILVA; LUCIO SARUBI FILMANN; CAMILA JANKE LOPES;
GUSTAVO FRANCO CARVALHAL; MARCELO GARCIA TONETO; HAMILTON PETRY DE SOUZA; FRANCIEL
LINNÉ
Background: It is recognized that there is a potential interaction between malignant cell growth and the coagulation pathway.
Recently, some studies suggested that tissue factor, a primary initiator of coagulation, is expressed in a variety of solid tumors in
association with increased angiogenesis. Design: The immunohistochemical expression of tissue factor and microvascular density