Anais da 27º Semana Científica - Hospital de Clínicas de Porto Alegre

190
Revista HCPA 2007; 27 (Supl.1)
FEVER INDUCED BY NITROFURANTOIN AS PROPHYLAXIS OF URINARY TRACT INFECTION- CASE REPORT
TIAGO FALCÃO CUNHA; HAYSLAN BOEMER; MARISTELA BOHLKE; FRANKLIN CORREA BARCELLOS;
ADRIANA BAPTISTA MENEZES; PAULO EDUARDO CARUSO
Introduction: Nitrofurantoin is an antibiotic frequently used in the treatment and prophylaxis of urinary tract infection (UTI).
Common adverse reactions are: nausea (8%), headache (6%), flatulence (1,5%) and, rarely (After 24hr, the patient returned to the
hospital complaining about fever, chills and drowsiness. She was in good general condition, no fever and normal physical
examination; she stayed at the hospital to have her daily temperature evaluated. In her first two days at the hospital she had no
fever and she wasn’t using nitrofurantoin. On the 3rd night, she had fever of 38.5, chills, headache and again, urinalysis,
hemoculture and chest x-ray, were done; the exams showed no alteration. By reviewing the case, it was noticed that the patient
had taken nitrofurantoin without medical prescription. The overall diagnosis was fever originated by drug. The drug was
suspended and the patient was discharged without any symptoms. Conclusion: antibiotic and antipyretics are frequently
recommended for fever disease. However, they are the most important drugs that cause drug-induced fever and they can be
misinterpreted as treatment failure.
PREVALENCE OF HIGH BLOOD PRESSURE AND ITS RELATION TO ANTHROPOMETRICS INDICES IN CHILDREN
PRESENTING TO A BRAZILIAN EMERGENCY ROOM
TIAGO FALCÃO CUNHA; MARISTELA BOHLKE; HAYSLAN BOEMER; FERNANDA DULLIUS; JULIANA MENEZES;
ADRIANA BAPTISTA MENEZES; PAULO EDUARDO CARUSO.
Introduction: The occurrence of high blood pressure (BP) in children has increased in association with increasing prevalence of
obesity in childhood. The aim of this study is to evaluate the prevalence of high BP and obesity and the relation among these
variables in a group of children who go to the pediatric emergency room (ER) in the municipality of Pelotas, Brazil. Methods:
Cross-sectional study with evaluation of BP, weight, height and body mass index (BMI) calculation in children between 3 and 12
years old selected in one pediatric ER. Children with systolic and or diastolic blood pressure levels greater than or equal to the
90th percentile were evaluated again in 15 days, and if the level remained high, these children would be reevaluated on a third
visit with complete clinical and complementary exams. Pre-hypertension was considered when mean BP levels were between 90-
95 percentiles on three consecutive evaluations and hypertension was defined as BP levels greater than or equal to the 95th
percentile in the three consecutives visits, according to “The fourth Report on the diagnosis, evaluation and treatment of high
blood pressure in children and adolescents”. Results: A total of 365 children were evaluated, 57,8% male, 81,4% white, mean age
of 6,7 years old, 17,3% overweight and 19,2% obese. The percentage of children with BP levels between 90-95 percentiles was
1,6%, 0,3% and 0,3% in the first, second and third consultations respectively. In the same order, 26,3%, 6,3% and 3,3% of
children had BP greater than or equal to the 95th percentile. Children with BP levels greater than or equal to the 95th percentile on
the mean of the three evaluations had their BMI higher when compared to the ones who had BP levels lower than 95th percentile
(pIn a group of 365 children submitted to an ambulatory treatment, 12 (3,3%) maintained their BP level greater than or equal to
the 95th percentile after the third evaluation. One child maintained the percentile between 90-95 (pre-hypertension). In this
sample of children, overweight and obesity were directly related to high blood pressure.
Cirurgia Proctológica
EFICÁCIA DO ANTAGONISTA DO PEPTÍDEO LIBERADOR DE GASTRINA (RC-3095) NO TRATAMENTO DA COLITE
INDUZIDA POR ÁCIDO ACÉTICO EM RATOS
RENATA HECK; FREDERICO SEDREZ DOS SANTOS; DANIEL DE CARVALHO DAMIN; MÁRIO A. ROSITO; RAFAEL
ROESLER; GILBERTO SCHWARTSMANN
Introdução: A retocolite ulcerativa (RCU) é uma doença inflamatória crônica do intestino grosso. Acredita-se que tenha causa
multifatorial, resultando da ativação crônica da cascata imunoinflamatória em indivíduos geneticamente predispostos. O
antagonista do receptor do peptídeo liberador de gastrina/bombesina (RC-3095) é um fármaco desenvolvido recentemente com
propriedades imunoreguladoras e anti-inflamatórias. Objetivo: Avaliar a eficácia do RC-3095 no tratamento da RCU, através da
utilização de um modelo experimental de colite induzida em ratos. Material e métodos: A indução da colite é realizada com
enema de ácido acético a 5%. Serão 60 ratos Wistar machos com 9 semanas de idade. Os animais serão randomizados para os
seguintes 4 grupos: tratamento com RC (subcutâneo), Mesalazina enema (tratamento padrão 1), corticóide subcutâneo (tratamento
padrão 2) e grupo controle. Os animais serão tratatos 24 e 48 horas após a indução da colite e sacrificados 24 horas após o último
dia de tratamento. Haverá uma avaliação macroscópica e microscópica dos cólons bem como dosagem de marcadores
inflamatórios no plasma. Resultados: até o momento foram estudados 20 ratos. Utilizando-se uma escala de intensidade da colite
produzida, com variação de entre 0 (ausência de colite) e 3 (colite grave com necrose da parede colônica) detectou-se a seguinte
variação entre os grupos: grupo colite sem tratamento = 3; grupo colite com tratamento RC = 1; grupo colite com mesalazina = 2;
grupo colite e corticóide = 1. Os resultados da análise microscópica e laboratorial do sangue ainda não estão disponíveis.
Conclusões: Nossos resultados preliminares apontam para a eficácia do RC-3095 no controle da colite induzida por ácido acético.
A definição do potencial da droga para utilização em modelos experimentais de colite e, eventualmente, no controle clínico de
pacientes com retocolite ulcerativa dependerá, primordialmente, da confirmação de nossos resultados iniciais.