[Abstract Title]. - Society for Neuroscience

only the 24hrs WR access (single-housed rats) significantly increased cytogenesis in DG after 12
days of exercise. These results suggest that voluntary exercise (24hr/day) in both social and
isolated housing conditions promotes cell proliferation and neurogenesis. Additionally, these
results suggest that repetitive removal from the running wheels (in the 12hrs exposure paradigm)
thwarts the exercise effect on cell proliferation and neurogenesis. Supported by NIAAA09838.
Disclosures: J.L. Helfer , None; C.J. Rocha, None; A.Y. Klintsova, None.
Poster
229. Neuronal and Glial Proliferation III
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 229.9/A9
Topic: A.02.a. Proliferation
Support: DGAPA IN204206
CONACYT V40286M
Title: Pacing behavior increase the number of cells in the accessory olfactory bulb in the adult
female rat
Authors: R. CORONA, *R. G. PAREDES;
Cognitivas, Inst. De Neurobiologia UNAM, Queretaro 76001 QRO, Mexico
Abstract: Neurogenesis in the olfactory bulb of rodents persists in adult life. This production of
new cells comes from the subventricular zone of the lateral ventricles, where cells originate and
migrate undifferentiated along the rostral migratory stream until they reach the accessory (AOB)
and main olfactory bulb (MOB) where they integrate as neurons or glia. The AOB is a structure
located in the dorsal and medial portion of the olfactory bulb. This structure plays and important
role in the modulation of behavioral responses elicited by pheromones, it processes
chemosensory sexually relevant cues by the vomeronasal organ. During mating a lot of olfactory
stimuli are provided that could influence the production of new cells. When the females pace
their sexual interaction, physiological and behavioral changes occur that favor gestation in
comparison to non-paced mating. The present experiment was aimed to determine if paced
sexual behavior induces neurogenesis in the OB. Ovariectomized hormonally primed females
were divided in different groups. One group was allowed to paced while another mated in a nonpaced
condition. All subjects were injected intraperitoneally with the mitotic marker BrdU one
hour before, at the end and one hour after mating. The rats were sacrificed 15 days after the test.
Brain sections were obtained and processed immunohistochemically to reveal BrdU-labeling.