[Abstract Title]. - Society for Neuroscience

of the regional cerebral metabolic rate for glucose (CMRgl) as a presymptomatic quantitative
endophenotype to evaluate putative genetic and non-genetic risk factors for AD.
Objective: To test the hypothesis that hypertension is associated with lower CMRgl in brain
regions affected by AD or normal aging. Secondly, examine whether higher higher systolic
blood pressure (SBP) and diastolic blood pressure (DBP) are inversely correlated with CMRgl in
these brain regions.
Methods: A brain mapping algorithm (SPM5) was used to characterize respective relationships
between higher SBP, higher DBP, and hypertension and lower CMRgl in 26 cognitively normal
persons (mean Mini-Mental State Examination [MMSE] score 29.4 ± 1.1) 60.6 ± 6.7 years of
age, including 6 apolipoprotein E (APOE) ε4 homozgotes (HM), 11 heterozygotes (HT), and 9
noncarriers (NC).
Results: Participants with and without hypertension did not differ significantly in their age,
gender, educational level or MMSE scores. Participants with hypertension had lower CMRgl
than those who did not in parietal regions previously associated with AD and in frontal regions
previously associated with AD and normal aging (p < 0.05 corrected for multiple comparisons).
Similarly, higher SBP and DBP were each associated with lower CMRgl in temporal regions
previously associated with AD and in frontal regions previously associated with normal aging (p
< 0.005 uncorrected for multiple comparisons).
Conclusions: These preliminary brain-imaging findings provide additional evidence that
hypertension along with higher SBP and DBP are associated with an increased risk of AD. This
study provides a foundation for using FDG PET to rapidly evaluate the efficacy of antihypertensive
treatments in the primary prevention of AD.
Disclosures: J.B.S. Langbaum, None; K. Chen, None; W. Lee, None; C. Recshke, None; S.
Reeder, None; D. Bandy, None; G.E. Alexander, None; R.J. Caselli, None; E.M. Reiman,
None.
Poster
247. Parkinson's Disease Interventions: Animal and Clinical Models
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 247.1/R8
Topic: C.02.d. Therapies
Support: (M103KV010021-06K2201-02110) from BRC
(R15-2006-020) from NCRC (ROK)
Title: Novel functional role of oxi gene family during oxidative stress induced dopamine
neuronal cell death