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[Abstract Title]. - Society for Neuroscience

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Poster<br />

279. Steroids and Plasticity I<br />

Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm<br />

Program#/Poster#: 279.20/MM34<br />

Topic: E.01.c. Steroids and plasticity<br />

Support: Generalitat Catalunya DURSI<br />

DOE grant MO-081<br />

NIH grants RO1MH064845 and KO2MH073090<br />

NSF grant BCS0224221<br />

<strong>Title</strong>: Structural changes in the human brain across the menstrual cycle<br />

Authors: *A. BIEGON 1 , A. CONWAY 2 , C. EPPERSON 3 , N. ALIA-KLEIN 1 , D. PARETO 4 , R.<br />

CONSTABLE 3 , T. CANLI 2 ;<br />

1 Med. Dept, Brookhaven Natl. Lab., Upton, NY; 2 Stony Brook Univ., Stony Brook, NY; 3 Yale<br />

Univ., New Haven, CT; 4 Inst. Alta Tecnologia, Barcelona, Spain<br />

<strong>Abstract</strong>: Postmenopausal women on hormone therapy show greater gray and white matter<br />

volumes than age-matched controls. This observation has been interpreted in terms of protective<br />

effects of ovarian hormones against aging-related volume decreases. Alternatively, the presence<br />

of ovarian hormones may directly promote structural changes, which should be observable in<br />

younger women. To test this hypothesis, 14 young healthy women with regular menstrual cycles<br />

were each scanned during the early follicular phase, when estrogen and progesterone plasmalevels<br />

are low, and the midluteal phase, when levels of both hormones are high. High-resolution<br />

(1mmx1mmx1mm) structural scans were obtained using a 3T MRI scanner. On each scan day,<br />

the subjects were evaluated <strong>for</strong> mood (POMS) and blood samples were taken <strong>for</strong> estrogen and<br />

progesterone measurement. Regional brain gray and white matter volume and density were<br />

measured and compared across menstrual cycle phases using voxel-based morphometry (VBM).<br />

There were no significant menstrual-cycle related changes in mood. Estrogen and progesterone<br />

levels were both significantly higher in the midluteal compared to the follicular stage, as<br />

expected (p

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