[Abstract Title]. - Society for Neuroscience

mice were found to be significantly more reactive compared to normal (suckle) controls
(p=0.005), while the deprived group was not different from the normal controls. PCP-treated
mice tended to be more reactive than the deprived group (p=0.09). However, unlike the results
from the B6-PCP study, no group differences were observed on an aggression index derived
from the results of the resident intruder test, which was conducted beginning on P70. On the
other hand, results from the tube test (P85) suggested that the neonatal PCP treatment had an
effect on dominance. Surprisingly, the deprived group was found to be the least dominant on this
test in that it had significantly fewer mice with large numbers of "wins" compared to the PCPtreated
and normal control groups. This finding had relevance for the PCP-treated mice since
they were also deprived of maternal care for the same period of time as the deprived group, yet
they still showed control-like levels of dominance, suggesting that PCP treatment led to an
increase in dominance-related behaviors. No notable effects were observed on the social choice
(P50) or elevated plus maze tests (P108). In conclusion, the differential strain effects of neonatal
PCP exposure on aggression and other agonistic behaviors underscores the importance of genetic
components in determining long-term behavioral consequences of NMDA-antagonist-induced
neuroapoptosis.
Disclosures: C.M. Yuede, None; S.E. Maloney, None; C.E. Creeley, None; N.B. Farber,
None; J.W. Olney, None; D.F. Wozniak, None.
Poster
232. Developmental Cell Death: Biological Effects
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 232.11/B51
Topic: A.06.a. Developmental cell death: Biological effects
Support: NIAAA Grant R01-AA06069
NIMH Grant K award for Lars Jarskog
Title: Acute and long-term prefrontal cortical deficits following post-natal exposure to MK801:
Linking neurotoxicity and neurodevelopmental disorders
Authors: *L. G. COLEMAN 1 , L. F. JARSKOG 2 , F. T. CREWS 3 ;
1 Univ. of NC- Chapel Hill, Chapel Hill, NC; 2 Columbia Univ., New York, NY; 3 Univ. of North
Carolina at Chapel Hill, Chapel Hill, NC
Abstract: Introduction: Treatment of rodents with ethanol at post-natal day seven (P7), a
developmental age that corresponds to the third trimester in humans, can be mimicked by the