[Abstract Title]. - Society for Neuroscience

We have studied the effect of OSU-6162 on quinpirole-induced changes in brain stimulation
reward and in spontaneous locomotor activity. We also compared the effect of OSU-6162 to that
of haloperidol, a prototypical dopamine antagonist. Male Sprague-Dawley rats were trained to
produce an operant response (nose-poke) in order to obtain a medial forebrain bundle electrical
stimulation. Once training was completed, we compared the effectiveness of OSU-6162 (10
mg/kg sc) and haloperidol (0.010 and 0.025 mg/kg, sc) at blocking the alteration of reward
induced by a dose of quinpirole (0.15 mg/kg sc) that produces a pre- and post-synaptic effect.
The pharmacological treatment was also tested on other groups of naïve rats on locomotor
activity. Results have shown that at the dose tested, quinpirole produced a time-dependent effect
on reward which consists of a suppression followed by a slight facilitation. The facilitation, but
not the suppression, effect was attenuated by OSU-6162 and by haloperidol. However, on
spontaneous locomotor activity both drugs blocked the suppressant effect of quinpirole. Timecourse
analysis of the changes in locomotor activity suggests that the lack of effect of OSU-6162
and haloperidol on quinpirole induced suppression of reward was due to the poor time resolution
of the curve-shift paradigm. These results demonstrate that OSU-6162 interacts at both pre- and
post-synaptic receptor sites to alter dopamine dependent behaviors in a manner consistent with a
functional antagonism.
Disclosures: F. Benaliouad , None; P. Rompré, None; S. Kapur, None.
Poster
298. Neural Mechanisms of Reward: Self-Administration and Opioid Modulation
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 298.23/TT56
Topic: F.03.d. Reward
Support: CIHR
NSERC
Title: NMDA receptor transmission in the medial prefrontal cortex modulates the encoding of
opiate-related reward information through amygdala and dopamine-dependent inputs
Authors: *S. F. BISHOP 1 , S. R. LAVIOLETTE 2 ;
1 Neurosci., Univ. Western Ontario, London, ON, Canada; 2 Anat. and Cell Biol., Univ. of
Western Ontario, London, ON, Canada
Abstract: Recent theories emphasize the significance of functional interactions between
emotional associative learning and memory formation mechanisms involving the dopamine (DA)