[Abstract Title]. - Society for Neuroscience

on lever presses. However, 10mg/kg and 20mg/kg BC did increase in the number of lever
presses in both strains, with 10mg/kg having the most profound effect. Although BC appeared to
increase the number of lever presses, BC also decreased rat chow intake. 1mg/kg and 10mg/kg
BC reduced chow intake in the OM rats. In the S5B rats, 10mg/kg and 20mg/kg BC decreased
chow intake. Interestingly, these results were not observed on the day of BC treatment but rather
on the following day. There was no effect on locomotor activity associated with BC treatment
but S5B rats showed greater locomotor activity prior to BC treatment.
Conclusion: Although OM and S5B rats differ in susceptibility to obesity and studies have
documented distinct high fat food preference between the two strains, this study shows these rats
do not differ in operant responding for high-fat food. BC increases operant response for high-fat
food but decreases chow intake in both strains. The increased operant response for high fat food
may potentially be attributed to a reduction in chow intake. Our findings may suggest D2R
agonism from BC affects neural systems associated with homeostatic control of food intake and
not food palatability.
Disclosures: J. Cho, None; R. Kim, None; M. Michaelides, None; V. Gopez, None; S.
Primeaux, Pennington Biomedical Research Center, A. Employment (full or part-time); G.
Bray, Pennington Biomedical Research Center, A. Employment (full or part-time); G.J. Wang,
Brookhaven National Laboratory, A. Employment (full or part-time); N.D. Volkow, National
Institutes of Health, A. Employment (full or part-time); Brookhaven National Laboratory, A.
Employment (full or part-time); P.K. Thanos, Brookhaven National Laboratory, A. Employment
(full or part-time).
Poster
291. Animal Cognition and Behavior: Learning and Memory: Pharmacology II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 291.14/RR89
Topic: F.02.j. Learning and memory: Pharmacology
Support: NIAAA Grant AA015515
NIDA Grant DA017949
Title: Interactive effects of ethanol and nicotine on memory, anxiety, and locomotion in
C57BL/6 mice in the plus-maze discriminative avoidance task
Authors: *D. GULICK, T. J. GOULD;
Psychology, Temple Univ., Philadelphia, PA