[Abstract Title]. - Society for Neuroscience

Disclosures: T.K. Karlsson , None; A. Karlen, None; A. Mattsson, None; K. Lundstrommer,
None; K. Pernold, None; S. Brene, None; A. Josephson, None; L. Olson, None.
Poster
239. Structural Plasticity at Synapses I
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 239.22/E19
Topic: B.08.i. Structural plasticity
Support: NIH
Loo and Hans Ostermans foundation for geriatric research
Swedish Brain Foundation
AFA
Swedish Research Council
Title: Nogo receptor 1 regulates formation of lasting memories
Authors: *A. KARLEN 1 , T. E. KARLSSON 1 , A. MATTSSON 1 , K. LUNDSTOMER 1 , K.
PERNOLD 1 , T. PHAM 2 , C. M. BACKMAN 3 , S. O. OGREN 1 , A. F. HOFFMAN 3 , M. A.
SHERLING 3 , C. R. LUPICA 3 , B. J. HOFFER 3 , C. SPENGER 1 , A. JOSEPHSON 1 , S. BRENE 2 ,
L. OLSON 1 ;
1 Dept Neurosci., Karolinska Inst., Stockholm, Sweden; 2 Dept. of Neurobiology, Caring Sci. and
Society, Karolinska Institutet, Stockholm, Sweden; 3 NIDA/NIH, Baltimore, MD
Abstract: Formation of lasting memories requires structural changes at the synaptic level. We
had found that neuronal activity down-regulates Nogo receptor-1 (NgR1), and postulated this to
be a key component of the plasticity required for formation of lasting memories. To test this, we
developed mice with inducible overexpression of NgR1 in forebrain neurons. While these mice
have normal long term potentiation and ability to remember 24 hours, their ability to remember 4
weeks is severely impaired (open-field, passive avoidance and swim maze tests). Blocking
transgene expression normalizes formation of lasting memories. Transcription of Nogo, Lingo-1,
Troy, endogenous NgR1 and BDNF were not changed, suggesting the impaired ability to form
lasting memories was directly coupled to the inability to down-regulate NgR1. Ongoing work
addresses the possible effects of NgR1 on cell proliferation and/or survival in the dentate gyrus,
as well as possible additional behavior endophenotypes. Our findings provide experimental