[Abstract Title]. - Society for Neuroscience

adolescence last well into adulthood, (b) nicotine and non-nicotine exposed adolescents do not
regulate fear in the same way later as adults, and (c) adults previously exposed to nicotine as
adolescents display a more immediate vulnerability to the effects of environmental stressors,
when those effects are measured during real-time exposure to the stressor. Supported by a grant
from the Virginia Tobacco Settlement Foundation.
Disclosures: R.C. Barnet , None; J.A. Burk, None; P.S. Hunt, None; J.C. Smyth, None.
Poster
291. Animal Cognition and Behavior: Learning and Memory: Pharmacology II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 291.24/SS7
Topic: F.02.j. Learning and memory: Pharmacology
Support: Plan de Promoción de la Investigación en la UNED
Agencia Antidroga de la Comunida de Madrid
ISCIII RD06/0001/0029
SAF2007-064890
S-SAL/0261/200
Title: Hippocampal glutamatergic systems in the hippocampus of adult animals chronically
exposed to a cannabinoid agonist during adolescence
Authors: *A. HIGUERA MATAS, M. MIGUENS, C. GARCÍA-LECUMBERRI, E.
AMBROSIO;
Psychobiology, UNED, Madrid, Spain
Abstract: Marihuana is the illicit drug most widely consumed during adolescence. This early
cannabinoid exposure has been linked to long lasting alterations in learning and memory
processes; however, as yet, the neural bases of these alterations remain largely unknown. Longterm
potentiation is the form of synaptic plasticity most directly related to information storage in
the brain and it heavily relies on glutamatergic neurotransmission. Given the relevance of this
amino acid transmitter in synaptic plasticity and learning and memory, we devised this study to
evaluate the long term changes in this system in the hippocampus of adult animals exposed to
cannabinoids during adolescence. We used Wistar albino rats of both sexes. The chronic