[Abstract Title]. - Society for Neuroscience

Program#/Poster#: 254.10/X27
Topic: C.15.d. Schizophrenia: Mutant animal models
Support: NARSAD
P50 MH077972
Title: Impacts of disruption of DISC1 at different post-natal time points on the
pathophysiology of schizophrenia in inducible transgenic mice
Authors: *W. LI 1 , T. CANNON 2 , A. SILVA 3 ;
1 Neurobiology, Psychiatry, 2 Psychology and Psychiatry and Biobehavioral Sci., 3 Neurobiology,
Psychiatry and Biobehavioral Sciences, Psychology and Brain Res. Inst., UCLA, Los Angeles,
CA
Abstract: DISC1 was initially discovered through analysis of a large Scottish kindred multiply
affected with schizophrenia, recurrent major depression, and other mental disorders. A region of
chromosome 1 was found to have a balanced translocation with
chromosome11(1;11)(q42.1;q14.3). Using an inducible and reversible transgenic system, we
have previously reported that induction of a C-terminal portion of DISC1 at postnatal day 7, but
not in adult mice, results in a cluster of schizophrenia-related phenotypes, including depressivelike
traits, abnormal spatial working memory and reduced sociability. Our findings demonstrate
that alterations in DISC1 function during brain development contribute to schizophrenia
pathogenesis. Here we utilize the Ligand Binding Domain of the Estrogen Receptor inducible
system to investigate the impact of disruption of DISC1 at various post-natal time points on the
pathophysiology of schizophrenia-related phenotypes. This work was supported by a NARSAD
award to WL and by NIH P50 MH077972 to AJS.
Disclosures: W. Li, NARSAD, B. Research Grant (principal investigator, collaborator or
consultant and pending grants as well as grants already received); T. Cannon, NARSAD, NIH,
B. Research Grant (principal investigator, collaborator or consultant and pending grants as well
as grants already received); A. Silva, NIH, B. Research Grant (principal investigator,
collaborator or consultant and pending grants as well as grants already received).
Poster
254. Schizophrenia: Mutant Animal Models
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 254.11/X28