[Abstract Title]. - Society for Neuroscience

as non-nociceptive (LTM) or nociceptive units according to their responses to natural stimuli.
1 week after nerve injury, intact L4 neurons showed electrophysiological changes. Although C
nociceptors showed greater changes in mSNA than SNA rats (presumably due to greater
inflammatory influences), changes in Aα/β units were generally greater in SNA rats, except
action potential (AP) height/overshoot in nociceptors that was greater in mSNA rats. We
therefore compared changes in Aα/β nociceptors and LTMs in SNA rats. Remarkably, these
changes were similar in both groups. Furthermore, although numbers were too small for
significance in all cases, the muscle spindle and different subgroups of cutaneous afferents (Field
and G hair, slowly adapting and rapidly adapting LTMs) all showed similar changes. These
included increased AP height and overshoot, and decreased AP duration and rise time, despite
decreased maximum rates of AP rise and fall.
These findings suggest that some global changes (perhaps in expression or properties of certain
types of ion channel) occur in all rapidly conducting intact L4 afferents in in a partially injured
nerve in SNA rats. Although there is no spontaneous firing in these A-fibres, our findings raise
the question of a) whether these changes are associated with changed functional properties of
these Aα/β neurons, and if so b) whether these changes occur in nociceptors and/or LTMs.
Supported by The Wellcome Trust, UK.
Disclosures: S.N. Lawson , Astrazeneca, B. Research Grant (principal investigator, collaborator
or consultant and pending grants as well as grants already received); L. Djouhri, None.
Poster
268. Neuropathic Pain Mechanisms: Ion Channels
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 268.12/GG9
Topic: D.08.l. Neuropathic pain: Mechanisms
Support: NINDS Grant KNS049420A
Title: Morphological distribution of sulfonylurea receptor 1 (SUR1) in peripheral sensory
neurons: the effect of nerve injury
Authors: *V. ZOGA 1 , M.-Y. LIANG 2 , T. KAWANO 2 , G. GEMES 2 , H.-E. WU 2 , S. ABRAM 2 ,
Q. HOGAN 2 , C. SARANTOPOULOS 2 ;
2 Anesthesiol., 1 MEDICAL COLL WISCONSIN, MIlwaukee, WI
Abstract: KATP channels, containing the SUR1 subunit, have been identified in primary
afferents 1 but details about their histological distribution remain unknown. Because KATP current
is altered by nerve injury 2 , we examined the localization of the SUR1 subunit in primary