[Abstract Title]. - Society for Neuroscience

Title: FEZ1 and NDEL1 interact with DISC1 in regulating integration of newly generated
neurons in the adult brain
Authors: E. KANG 1 , X. DUAN 1 , S. GANESAN 2 , J. CHANG 2 , B. LU 2 , H. SONG 1 , *G.-L.
MING 1 ;
1 Dept Neurol & Neurosci, Johns Hopkins Univ., Baltimore, MD; 2 Neurosci., Natl. Inst. of Hlth.,
Bethesda, MD
Abstract: Disturbed adult neurogenesis is increasingly appreciated as a potential factor for
pathogenesis of psychiatric disease. Disrupted-in-Schizophrenia 1 (DISC1) is one of the
susceptibility genes for schizophrenia and other major mental illness. Our previous study
demonstrated that newborn dentate granule cells with DISC1 knockdown exhibit aberrant
morphogenesis, mispositioning and accelerated dendritic development in the adult brain. How
DISC1 regulates different aspects of neural development in the adult brain is largely unknown.
Based on previously identified DISC1 interacting proteins and their expression patterns, we
investigated functions of two DISC1-interacting proteins: fasciculation and elongation proteinzeta1
(FEZ1) and NDEL1 in newborn neurons of the adult mouse hippocampus. Interestingly,
retrovirus-mediated knockdown of FEZ1 or NDEL1 in newborn neurons of the adult dentate
gyrus differentially phenocopies the defects by DISC1 knockdown. Furthermore, synergistic
effects were observed when any two of the three molecules were knock down simultaneously.
Taken together, our study identified the functional interaction of DISC1 with FEZ1 and Ndel1 in
regulating adult hippocampal neurogenesis.
Disclosures: E. Kang, None; G. Ming , None; X. duan, None; S. Ganesan, None; J. chang,
None; B. lu, None; H. Song, None.
Poster
230. Cell Migration: Molecules Mediating Migration
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 230.6/A32
Topic: A.02.c. Cell migration
Support: Hereditary Disease Foundation
Title: SDK2 downregulation disrupts migration in the adult rostral migratory stream
Authors: *S. S. MAGAVI 1 , W. KELSCH 1 , L. KAUFMAN 2 , H. SHIN 3 , J. R. SIMS 3 , P.
KLOTMAN 2 , C. LOIS 1 ;