[Abstract Title]. - Society for Neuroscience

W/control values. After AE, 11 proteins had differential expression across the rat lines; whereas,
after CE, 23 proteins had differential expression across the rat lines. Actb (actin), Aldh6a1
(methylmalonate semialdehyde dehydrogenase), Atp5b (ATP synthase subunit beta), Gmpr2
(guanosine monophosphate reductase 2), Rad23b and Sord (sorbitol dehydrogenase) were
differentially expressed under both AE and CE conditions. P rats displayed both decreased
levels, and the lowest levels of the 3 lines for all of these proteins except Aldh6a1. For Aldh6a1,
P rats displayed increased levels and the highest levels of the 3 lines. GO analysis of
differentially expressed proteins revealed innate rat line differences, notably in mitochondrial
proteins of the HW compared with the P and NP lines, with the P and NP lines differing little in
this regard. These data suggest line-specific responses to E exposure that may be related to
unique innate phenotypes.
Disclosures: R.L. Bell , None; H. Ringham, None; Z. Rodd, None; F.A. Witzmann, None; D.
Ji, None; T. Li, None.
Poster
257. Alcohol Intake and Preference
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 257.9/Z26
Topic: C.16.a. Alcohol
Support: NIH Grant R01 AA015741
NIH Grant R24 AA015512
Title: Enhanced orosensory-mediated responding to alcohol and sucrose in selectively bred
alcohol-preferring (P) rats compared to alcohol-nonpreferring (NP) and Wistar rat lines
Authors: *B. C. SILBAUGH, M. KETCHUM, S. M. BRASSER;
Dept Psychol, San Diego State Univ., San Diego, CA
Abstract: Alcohol is a salient, complex orosensory stimulus that directly activates the sweet
taste system (Hellekant et al., 1997; Kiefer and Mahadevan, 1993; Lemon et al., 2004) as well as
oral trigeminal circuits (Carstens et al., 1998) responsible for the detection and processing of
irritant stimuli. Research in rodents and humans has supported a genetically based positive
association between preference for alcohol and sweet substances, with enhanced consumption of
sweet-tasting solutions being one of the strongest phenotypic predictors of alcohol intake
common across alcohol-preferring rodent lines/strains (Overstreet et al., 1993; Sinclair et al.,
1992; Stewart et al., 1994; Woods et al., 2003). Although the mechanisms underlying inherited