[Abstract Title]. - Society for Neuroscience

egions including caudate-putamen. Interestingly, there were no large areas of the brain that
exhibited decreases in WIN-stimulated [ 35 S]GTPγS binding, but several regions illustrated no
significant changes, including the substantia nigra, globus pallidus, and cerebellum. Overall,
WIN-stimulated [ 35 S]GTPγS autoradiography revealed a unique global profile of receptormediated
G-protein activity in epileptic animals, and thus illuminated specific regions of the
epileptic brain that may serve as targets for cannabinimimetic compounds or manipulation of the
endocannabinoid system.
Disclosures: K.W. Falenski, None; L.S. Deshpande , None; P.T. Nguyen, None; R.E. Blair,
None; L.J. Sim-Selley, None; R.J. DeLorenzo, None.
Poster
250. Epilepsy: Networks
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 250.8/V20
Topic: C.06.h. In vivo mechanisms
Support: P50-DA005274
U01-NS058213-01
R01-NS051505-01
R01-NS052529-01
Title: Pilocarpine-induced status epilepticus in rats causes an acute decrease in CB1 receptor
protein levels and mRNA expression
Authors: *D. S. CARTER, K. W. FALENSKI, R. E. BLAIR, R. J. DELORENZO;
Neurol., Virginia Commonwealth Univ., Richmond, VA
Abstract: Acquired epilepsy is characterized by the occurrence of spontaneous recurrent
seizures. This form of epilepsy is caused by an injury to the brain such as stroke or status
epilepticus (SE). Following the initial injury, there is a 1-4 month epileptogenic period during
which time many plasticity changes occur prior to the onset of spontaneous seizures. It has been
well established that cannabinoids exhibit anticonvulsant properties through their interaction
with the CB1 receptor (Wallace et al, 2001, Eur J Pharmacol; Marsciano et al, 2003, Science).
There is growing evidence that the endocannabinoid system regulates excitatory and inhibitory
synaptic transmission during epilepsy. Our lab has recently shown that a long term and