[Abstract Title]. - Society for Neuroscience

Title: A novel free radical scavenger:platinum nanoparticle improves neurological signs and
electrophisiological findings in a rat EAE model via quenching ROS and NO
Authors: *H. YOSHIDA, M. SAGIC, J. SCHWERMAN, K. J. SMITH;
Neuroinflammation, Neurol, Univ. Coll London, London, United Kingdom
Abstract: Platinum nanoparticles were prepared by an alcohol reduction method and
complementarily stabilized with polyacrilic acid(PAA-Pt). The average diameter of PAA-Pt was
about 2nm. They were well dispersed in water and became colloidal solution. PAA-Pt efficiently
quenched superoxide anion(O(2)(-)), Hydrogen peroxide(H(2)O(2))and Nitric oxicide(NO). This
quenching activity against ROS and NO persisited like catalysis such as SOD or catalase.
Therefore, PAA-Pt may be a useful scavenger which is effective on medical treatment of
oxidative stress diseases. In fact, we have shown that platinum nanoparticles are effective on
animal models of various ROS-related diseases like stroke, Alzheimer's disease, Huntinton
disease and so on. And this time, we evaluated the effect of PAA-Pt on experimental
autoimmune encephalomyelitis(EAE) using a rat. Intravenous injection of PAA-Pt improves
neurological signs and electrophysiological findings in an EAE rat model.
Disclosures: H. Yoshida, None; M. Sagic, None; J. Schwerman, None; K.J. Smith, None.
Poster
252. Demyelinating Disorders: Mechanisms and Therapeutics II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 252.9/W33
Topic: C.08.d. Therapeutic strategies
Support: National Multiple Sclerosis Society PP1247
Title: Potential experimental therapy to improve Multiple Sclerosis (MS) symptoms in an animal
model
Authors: P. K. BOSE 1,3 , J. HOU 3 , *C. PHADKE 4 , R. SMITH 3 , R. PARMER 3 , Y. CHENG 3 , P.
M. HOFFMAN 2 , W. STREIT 3 , F. J. THOMPSON 3 ;
1 BRRC, 2 Res. Service, North Florida/South Georgia VAMC, Gainesville, FL; 3 Neurosci., Univ.
of Florida, McKnight Brain Inst., Gainesville, FL; 4 Univ. Florida, Gainesville, FL
Abstract: Symptoms and disabilities of MS appear across a broad spectrum, including spasticity,
weakness, cognitive impairment, and balance disorder. Our recent Experimental Autoimmune
Encephalomyelitis (EAE) rat model has revealed significant neurophysiological, locomotor,