[Abstract Title]. - Society for Neuroscience

evoked by synaptic stimulation, and suggest an increase in feed-forward inhibition in CA1.
Together, an increase in excitation and inhibition may act to increase the signal-to-noise ratio of
information flowing through the hippocampus as the CS-US association is stored.
Disclosures: B.M. McKay , None; J.F. Disterhoft, None.
Poster
240. Intrinsic Membrane Properties: Modulation of Neuronal Firing Properties by Inputs
and Activity
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 240.15/E37
Topic: B.10.c. Activity-dependent plasticity of intrinsic membrane properties
Support: NAAR (DPS)
NIH AG08796 & US-Israel Binational Sci Fnd #2005370 (JFD)
NIH MH071316 & NARSAD (PP)
NIH AG20506 (BMM)
Title: Learning trace eyeblink conditioning altered protein levels of AHP contributors in
CA1/subiculum
Authors: *M. M. OH, D. P. SRIVASTAVA, B. M. MCKAY, K. SCHOEDEL, P. PENZES, J.
F. DISTERHOFT;
Dept Physiol., Northwestern Univ. Med. Sch., Chicago, IL
Abstract: The postburst afterhyperpolarization (AHP) is a Ca 2+ -dependent K + current with 2
distinct phases. Apamin sensitive SK2 channels mediate the medium AHP, and play a role in
regulating NMDA receptor mediated synaptic plasticity in dendritic spines of CA1 neurons
(Ngo-Ahn et al, 2005). The channel underlying the slow AHP is not yet identified, however, a
neuronal calcium sensor, hippocalcin, was shown to be its intracellular mediator (Tzingounis et
al, 2007). Blocking of L-type Ca 2+ channels causes a ~30% reduction in the slow AHP in CA1
neurons (Power et al, 2002). Importantly, the AHP is reduced in hippocampal pyramidal neurons
ex vivo after an animal has learned a hippocampus-dependent task (Disterhoft & Oh, 2006).
Thus, we examined potential learning-related alterations in protein levels of these 3 AHP
contributors in the CA1/subiculum (CA1/S) region from 3-4 mo F344xBN rats after trace
eyeblink conditioning (EBC).