[Abstract Title]. - Society for Neuroscience

day 20 to 40 (restricted-running), and access freely again from day 41 to 59 (unbound-running-
2). Wheeling activity gradually increased from day 1 to 7, and stabilized around at 1,500 (an
arbitrary unit) after day 8. During the restricted-running, wheeling activity decreased to
approximately 300, however the wheeling activity jumped up to 700 during the unboundrunning-2,
though the level was still lower than that in the unbound-running-1 period, which may
probably be due to the change of set point of the wheel running during the running restriction.
During the restricted-running period, food intake was significantly higher than that during both
unbound-running-1 and -2 periods, suggesting that occasional running restriction changes
regulation of food intake positively. This escalation is rather contradictory from the view of
energy homeostasis, but for rats, they would have much time to eat foods instead of the time for
running. When they could run for 24 hrs again, food intake returned to the levels of unboundrunning-1.
Thus, the complete running deprivation and restricted running differently affected the
relation between running and food consumption. For the start or re-start of full running activity
in rats, an introduction of anorexic stage must be indispensable. One possible explanation may be
that rats try to find “running time” at expense of “eating time” until the putative flip-flop
regulatory system is established. This regulation, if any, would have substantial influence on
body weight control.
Disclosures: M. Bannai, Ajinomoto Co., Inc., A. Employment (full or part-time); K. Kasuh,
None; K. Nakahara, University of Miyazaki, A. Employment (full or part-time); N. Murakami,
University of Miyazaki, A. Employment (full or part-time); M. Takahashi, Ajinomoto Co., Inc.,
A. Employment (full or part-time).
Poster
285. Sleep: Molecular, Cellular and Pharmacology I
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 285.1/QQ17
Topic: E.08.c. Sleep: Molecular, cellular, and pharmacology
Support: NIH Grant NS34004
NIH Grant MH59839
Title: Pontine-wave (P-wave) generator activation-dependent memory processing involves
protein kinase A (PKA) activation-mediated brain-derived neurotrophic factor (BDNF)
expression in the CA3 subfield of dorsal hippocampus
Authors: *S. DATTA, J. L. SHEA;
Dept Psychiatry, Boston Univ. Sch. Med., Boston, MA