[Abstract Title]. - Society for Neuroscience

the prefrontal cortex, amygdala, locus coeruleus and dorsal raphé. Fluoxetine also decreased
amygdala CRH expression and increased locus coeruleus TH and dorsal raphé TPH2 expression.
Since glucocorticoids increase amygdala CRH and inhibit expression of locus coeruleus TH and
dorsal raphé TPH2, these fluoxetine effects are consistent with fluoxetine-induced decreases in
GR. We previously found that imipramine increased prefrontal cortex GR and decreased dorsal
raphé GR while increasing dorsal raphé TPH2 and decreasing locus coeruleus TH. Phenelzine, in
contrast, decreased prefrontal cortex and locus coeruleus GR while increasing locus coeruleus
TH. Thus, in support of our hypothesis, fluoxetine had effects that were similar to aspects of both
TCA and MAOI action. These effects may be relevant to fluoxetine‟s efficacy in treating both
melancholic and atypical depression. Also, since elevated amygdala CRH has been linked to
increased anxiety, fluoxetine-induced decreases in amygdala CRH may provide insight into the
anxiolytic effects of SSRIs.
Disclosures: W.A. Heydendael , None; L. Jacobson, None.
Poster
255. Mood Disorders: Animal Models and Treatment Effects II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 255.12/Y27
Topic: C.15.h. Affective disorders: Animal models
Support: CIHR grant MOP42438
Croatian Ministry of Science, Education and Sport grant 219-1081970-2032
Title: Chronic treatment with citalopram changes density of the serotonin transporter in some
brain regions in FSL and SD rats
Authors: *I. SKELIN 1 , T. KOVACEVIC 2,3 , M. DIKSIC 2,3 ;
2 Neurol. and Neurosurg., 1 McGill Univ., Montreal, QC, Canada; 3 Fac. of Med., J.J. Strossmayer
Univ., Osijek, Croatia
Abstract: The Flinders Sensitive Line (FSL) rat is an animal model of depression [Neurosci
Biobehav Rev 29(2005)739-59], selectively bred from the Sprague-Dawley (SD) strain for
increased cholinergic sensitivity. FSL rats exhibit some behavioral, sleep and immunological
abnormalities similar to those found in depressed humans. Citalopram is a selective serotonin
reuptake inhibitor (SSRI), with the highest selectivity for the serotonin transporter (SERT)
among the clinically used SSRIs. Chronic therapy with citalopram reduces the immobility in FSL
rats in the forced swim test, considered to be a predictor of an antidepressant response in