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Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm Program#/Poster#: 236.18/D18 Topic: B.06.a. Docking and fusion Title: Alpha-synuclein inhibits arachidonic acid-induced exocytosis and SNARE complex formation Authors: *F. DARIOS 1 , I. LOPEZ 2 , L. M. GUTIÉRREZ 2 , B. DAVLETOV 1 ; 1 Lab. Mol Biol, Med. Res. Council, Cambridge CB2 0QH, United Kingdom; 2 Univ. Miguel Hernández, Inst. de Neurociencias, Alicante, Spain Abstract: Alpha-synuclein is a small cytosolic protein involved in several neurodegenerative diseases including Parkinson‟s disease, but its physiological function is unknown. Recently, alpha-synuclein has been proposed to regulate the function of SNAREs (soluble Nethylmaleimide-sensitive factor attachment protein receptors), a set of proteins involved in vesicle fusion. However, the mechanism of regulation remains unknown. Alpha-synuclein fails to interact with SNARE proteins suggesting an indirect mode of action. We have recently shown that polyunsaturated fatty acids act on one of the SNARE proteins, syntaxin, enhancing the formation of SNARE complex which is instrumental for neurotransmitter release. Since alpha-synuclein is also sensitive to polyunsaturated fatty acids, we analysed alpha-synuclein effects on fatty acid-mediated SNARE interactions. Here we show that arachidonic acid, an omega-6 polyunsaturated fatty acid involved in the regulation of neurotransmitter release, stimulates SNARE complex formation and exocytosis, whereas alphasynuclein blocks this action both in vitro and in vivo. This effect is due to the ability of alphasynuclein to sequester arachidonic acid, thereby blocking the activation of syntaxin. Our data shed new light on the action of alpha-synuclein in the modulation of neurotransmission. Disclosures: F. Darios, None; B. Davletov, None; L.M. Gutiérrez, None; I. Lopez, None. Poster 236. Neurotransmitter Release: Docking and Fusion Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm Program#/Poster#: 236.19/D19 Topic: B.06.a. Docking and fusion Support: NSF Grant 0544031
Title: Regulation of levels of UNC-13 at synapses in Caenorhabditis elegans Authors: *B. M. KAAS, R. WENNELL, T. LIMOUZE, R. LAWSON, R. KOHN; Ursinus Col., Collegeville, PA Abstract: Synaptic neurotransmission is a highly regulated process. The nematode Caenorhabditis elegans has a well-characterized nervous system that has been intensively investigated in the study of neurotransmission. This organism‟s nervous system has functional similarity to those of higher organisms. The UNC-13 protein, which operates at the pre-synaptic membrane of C. elegans, participates in the fusion of synaptic vesicles to allow neurotransmitter release into the synapse. Defects in unc-13 result in decreased release of neurotransmitters and paralysis. We identified an F-box protein that interacts with UNC-13. F-box proteins participate in ubiquitin ligase complexes and in Drosophila, DUNC-13 is degraded via the ubiquitin proteasome pathway. This UNC-13/F-box interaction may therefore indicate that UNC-13 is tagged for proteasomal degradation with ubiquitin by the ligase complex in C. elegans. The C. elegans knockout consortium isolated a strain with a large deletion in the coding region of the gene that codes for the F-box protein. If the F-box protein is indeed involved in the degradation of UNC-13, this strain would be expected to have higher levels of UNC-13, which could result in changes in phenotypes. We characterized the F-box deletion mutant by assaying brood size, developmental rate, and body bends per minute. Aldicarb assays were used to determine whether a deletion in the gene coding for the F-box protein alters the response to inhibitors of acetylcholinesterase. We found that the deletion resulted in changes in developmental rate and in aldicarb sensitivity. We are continuing to study strains with mutations in both the gene coding for the F-box protein and in unc-13. Disclosures: B.M. Kaas , None; R. Wennell, None; T. Limouze, None; R. Lawson, None; R. Kohn, None. Poster 236. Neurotransmitter Release: Docking and Fusion Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm Program#/Poster#: 236.20/D20 Topic: B.06.a. Docking and fusion Title: Carboxypeptidase E cytoplasmic tail mediates docking/exocytosis of synaptic vesicles Authors: *J. J. PARK 1 , H. LOU 1 , N. X. CAWLEY 1 , A. SARCON 1 , T. ADAMS 2 , Y. LOH 1 ; 1 NICHD, NIH, Bethesda, MD; 2 QIAGEN, Germantown, MD
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When citing an abstract from the 20
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229. Neuronal and Glial Proliferati
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Poster 229. Neuronal and Glial Prol
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Time: Sunday, November 16, 2008, 1:
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exaggerated when opioid receptor fu
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Our results shows an increase in Br
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the olfactory bulb and also directl
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proliferation and differentiation o
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acute administration of corticoster
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projection neurons. The large size
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surgery. Our study demonstrates tha
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coinciding with the time of light o
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hippocampus using an exhaustive ste
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Abstract: Psychological stress and
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Program#/Poster#: 230.1/A27 Topic:
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Title: FEZ1 and NDEL1 interact with
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Support: Manitoba Institute of Chil
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Support: NIH Grant NS-46616 (R01) T
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Disclosures: J.M. Han, None; M. Hir
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NIH Grant 5RO1NS031234 Title: The r
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Support: NIH grants NS23022 and NS3
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the midline. Intriguingly, MsSrc ma
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in Netrin-1 -/- and DCC-KO were mul
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located in the superficial mantle o
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addition, the pyramidal tract marke
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Authors: *L. A. TAN 1 , A. AL CHAWA
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Support: NSERC Title: Elucidating a
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Program#/Poster#: 231.6/B19 Topic:
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Topic: A.04.i. Dendritic growth and
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Searle Scholar Award Dana Program i
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Poster 231. Dendrite Growth and Bra
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NIH EY012190 OUHSC NIH EY10608 NIH
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231. Dendrite Growth and Branching:
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Title: CaMKIIδ promotes axonal and
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Page 73 and 74:
Poster 231. Dendrite Growth and Bra
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231. Dendrite Growth and Branching:
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Disclosures: M. Warren , None; W. B
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Poster 232. Developmental Cell Deat
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numbers of neuronal and non-neurona
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NIH Grant DA05072 NIH Grant NS05710
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Poster 232. Developmental Cell Deat
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mice were found to be significantly
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DGAPA-UNAM (IN223107) Title: Effect
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white matter, projecting in a wides
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DGAPA IN-214607-3 Title: Rotenone-i
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232. Developmental Cell Death: Biol
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cortices), only neonatal PCP treatm
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proapoptotic activity. When RGM was
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Luca et al., 1996). However, beside
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1 Dept Hyg., Kanazawa Univ. Sch. Me
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Poster 233. Nicotinic Aacetylcholin
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acetylcholine. These results sugges
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[ 3 H]epibatidine with nanomolar af
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esponses on the human alpha4/beta2
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Support: GM57481-05A2 Title: Identi
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Topic: B.02.c. Nicotinic acetylchol
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Program#/Poster#: 233.15/C17 Topic:
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Disclosures: A.J. Hone , None; Y. X
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Poster 233. Nicotinic Aacetylcholin
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Disclosures: A.P. Govind, None; H.S
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chronic effects of nicotine in vivo
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234. A-Type Potassium Channels Time
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Program#/Poster#: 234.5/C29 Topic:
Page 135 and 136:
Poster 234. A-Type Potassium Channe
Page 137 and 138: immunostaining with a marker for se
Page 139 and 140: Authors: *Z. M. KHALIQ, B. P. BEAN;
Page 141 and 142: Title: Messenger RNA and protein ex
Page 143 and 144: Program#/Poster#: 234.14/C38 Topic:
Page 145 and 146: 234. A-Type Potassium Channels Time
Page 147 and 148: Disclosures: W.C. de Groat, None; A
Page 149 and 150: potential therapeutic benefits of 1
Page 151 and 152: complex rectification of Kir4.1 cha
Page 153 and 154: Authors: *C. F. BARRETT 1 , L. A. M
Page 155 and 156: Poster 235. Ion Channels in Disease
Page 157 and 158: use a neuronal cell-type specific p
Page 159 and 160: The therapeutic index, as determine
Page 161 and 162: several components. The fast compon
Page 163 and 164: Abstract: TRPM7 channels are Ca 2+
Page 165 and 166: a shRNA knockdown approach to selec
Page 167 and 168: Alzheimer‟s disease, Parkinson‟
Page 169 and 170: Title: Electrical fusion pore measu
Page 171 and 172: large secretory vesicles.
Page 173 and 174: Title: Vesicle membrane bending ene
Page 175 and 176: Title: Transient narrow fusion pore
Page 177 and 178: Program#/Poster#: 236.7/D7 Topic: B
Page 179 and 180: molecular determinants of this vari
Page 181 and 182: Disclosures: R.E. Guzman , None; Y.
Page 183 and 184: Poster 236. Neurotransmitter Releas
Page 185 and 186: Program#/Poster#: 236.15/D15 Topic:
Page 187: Topic: B.06.a. Docking and fusion S
Page 191 and 192: Title: Identification and character
Page 193 and 194: Grants-in-Aid for Scientific Resear
Page 195 and 196: Support: KB is a recipient of the f
Page 197 and 198: We conclude that the both excitator
Page 199 and 200: translocation. In neurons clamped a
Page 201 and 202: Variation in sensory pathways allow
Page 203 and 204: Disclosures: S. Kodama, The Ministr
Page 205 and 206: immobilization, cardiac arrest) is
Page 207 and 208: of the PFC, hippocampus and VTA to
Page 209 and 210: Program#/Poster#: 237.12/D37 Topic:
Page 211 and 212: 237. Synaptic Integration II Time:
Page 213 and 214: apamin (20 nM) increased spike rate
Page 215 and 216: also dynamically arise from Cl flux
Page 217 and 218: Support: NIH Grant EY11850 HHMI Tit
Page 219 and 220: 238. LTD: Hippocampus and Cortex Ti
Page 221 and 222: Disclosures: T. Ho, None; K.A. Pelk
Page 223 and 224: Poster 238. LTD: Hippocampus and Co
Page 225 and 226: Time: Sunday, November 16, 2008, 1:
Page 227 and 228: Support: Ray Thomas Edwards Foundat
Page 229 and 230: Poster 238. LTD: Hippocampus and Co
Page 231 and 232: polarization assay. The screen yiel
Page 233 and 234: Abstract: Here we describe the disc
Page 235 and 236: of synaptic plasticity in the later
Page 237 and 238: initiated studies to determine whet
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compartment. Here, by application o
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from live imaging experiments of hi
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inhibition were balanced. Afterward
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Italian MIUR San Paolo Foundation M
Page 247 and 248:
Poster 239. Structural Plasticity a
Page 249 and 250:
Israel Science Foundation (768/06)
Page 251 and 252:
Abstract: Chemical synapses serve a
Page 253 and 254:
Howard Hughes Medical Institute Tit
Page 255 and 256:
Abstract: Recently structural plast
Page 257 and 258:
Abstract: Previous work from our la
Page 259 and 260:
Program#/Poster#: 239.16/E13 Topic:
Page 261 and 262:
Program#/Poster#: 239.18/E15 Topic:
Page 263 and 264:
Oxidation-state-dependent interconn
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Disclosures: T.K. Karlsson , None;
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oth cell type-specific and cell typ
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identified. Indeed, some of these s
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242). No significant differences in
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Title: Alterations of Ih dynamics u
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240. Intrinsic Membrane Properties:
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Support: NIH grant AA14973 Title: E
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Page 281 and 282:
Poster 240. Intrinsic Membrane Prop
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evoked by synaptic stimulation, and
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Title: Activity-dependent bidirecti
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Topic: B.10.b. Modulation of neuron
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240. Intrinsic Membrane Properties:
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Disclosures: J.T. Brown, None; A.D.
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Picrotoxin). The induction protocol
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axons at DIV 18-22. Using this syst
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histochemistry, the present study f
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temporal and spatial expression of
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Authors: M. TOSIC 1 , I. ALLAMAN 2
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OGS CIHR Title: Brain-specific cros
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Authors: *N. D. AMIN 1 , Y. ZHENG 1
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Support: MA 037 Title: Process form
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Title: Plp gene mutation results in
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paranodal, ECM, and axonal cytoskel
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sensitive dye Fura-2 were loaded in
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survival and specification to a TuJ
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immunohistochemisty revealed that t
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microchannels into the axon/glia co
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Hippocampal astrocytes were electro
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Authors: *G. PEREA, A. ARAQUE; Dept
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Program#/Poster#: 242.5/H12 Topic:
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242. Glial Neuronal Interactions: G
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242. Glial Neuronal Interactions: G
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CAM-CSIC (200620M083) European Unio
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NS059028 DE018573 NS060735 Title: A
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Program#/Poster#: 242.17/I12 Topic:
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stimuli, but is potentiated by sust
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Poster 242. Glial Neuronal Interact
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key parameters involved using a sen
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Abstract: Alzheimer‟s disease (AD
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The Children‟s Foundation for Sle
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NIH Grant NS43946 NIH Grant AG 0274
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pGluAbeta(3-42). The isolated regul
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modulates neuronal function and syn
Page 355 and 356:
Authors: N. NEMIEBOKA 1 , S. THOMAS
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243. Abeta Assembly and Deposition
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is comparable to those in APP/Abca1
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event in the aggregation of Aβ42.
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3 Dept Psychiat & Pharmacol, Vander
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Poster 244. Abeta Toxicity I Time:
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SY5Y and SH-SY5Y/pEGFP-LC3 cells. O
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CA1. For evaluation of cell surviva
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Aβ(1-42) in water (100 κM) did no
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in either dentate gyrus or CA field
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the α-secretase product (s-APP-α)
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Support: National Health and Medica
Page 379 and 380:
Page 381 and 382:
Page 383 and 384:
Page 385 and 386:
diminished Aβ immunofluorescence i
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A Grant-in-aid for Promotion of Sci
Page 389 and 390:
Program#/Poster#: 245.2/N8 Topic: C
Page 391 and 392:
Aβ immunotherapy in uninjured 3xTg
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Authors: *Q.-L. MA, O. J. UBEDA, W.
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Page 397 and 398:
overlay assays. Caspase activation
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expressed in the hippocampal format
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Tau mice as compared with P301L Tau
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Dab1 by Cre-mediated recombination
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neuroprotective effects could arise
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process of neurite outgrowth. Tau f
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common dementia among older people
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Program#/Poster#: 245.22/P4 Topic:
Page 413 and 414:
Methods: Data from the WBDS was col
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Topic: C.01.o. Imaging and biomarke
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Poster 246. Alzheimer's Imaging and
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somatodendritic distribution. A ser
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neurodegenerative syndromes, little
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compared to the controls. After con
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invasive in vivo magnetic resonance
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Poster 246. Alzheimer's Imaging and
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Disclosures: N.C. Berchtold , None;
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fusiform gyrus, and Brodmann area 1
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Authors: *S. KIM, K. CHOI, J. HA, J
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zonisamide 1) elevates the brain co
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Abstract: Ghrelin targets the hypot
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Program#/Poster#: 247.7/S2 Topic: C
Page 441 and 442:
neuroprotective mechanism, further
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and two-dimensional electrophoretic
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Abstract: The present study was des
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Title: Effect of tissue capacitance
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Poster 247. Parkinson's Disease Int
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hyperactivity during the task and f
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effects on dopaminergic neurons in
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Support: 2005-2006 American Foundat
Page 457 and 458:
support the idea that RAS may encou
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contrast, pramipexole and pergolide
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Unilateral intrastriatal injection
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Title: L-DOPA-induced dyskinesia in
Page 465 and 466:
Program#/Poster#: 248.2/U1 Topic: C
Page 467 and 468:
Topic: C.03.j. Dystonia Support: Gr
Page 469 and 470:
Poster 248. Dystonia Time: Sunday,
Page 471 and 472:
Poster 248. Dystonia Time: Sunday,
Page 473 and 474:
disulfide-bonds in torsinA(ΓE) oli
Page 475 and 476:
protein kinase C (PKC) activation.
Page 477 and 478:
often exhibits diverse psychiatric
Page 479 and 480:
training between the groups. Partic
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abnormal postures. It is often hypo
Page 483 and 484:
Support: Deutsche Forschungsgemeins
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Title: Effects of early exposure to
Page 487 and 488:
Support: HD 20608 Title: Assessment
Page 489 and 490:
Program#/Poster#: 249.5/U24 Topic:
Page 491 and 492:
short silent gap), as well as in pr
Page 493 and 494:
Abstract: We have previously report
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Do Rio Grande do Sul, Porto Alegre,
Page 497 and 498:
Poster 249. Dyslexia, SLI, and Othe
Page 499 and 500:
with the behavioral deficit, spine
Page 501 and 502:
50-60% decrease of both parvalbumin
Page 503 and 504:
morphine, nicotine, caffeine, chron
Page 505 and 506:
and NRB rats were given a daily i.p
Page 507 and 508:
Poster 249. Dyslexia, SLI, and Othe
Page 509 and 510:
appears to desensitises response to
Page 511 and 512:
Title: The neurobiological profile
Page 513 and 514:
epresentation is superior to the re
Page 515 and 516:
sensory and motor cortex during spe
Page 517 and 518:
Abstract: Temporal lobe epilepsy is
Page 519 and 520:
Authors: *X. E. NDODO-EKANE, J. NIS
Page 521 and 522:
Topic: C.06.h. In vivo mechanisms T
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250. Epilepsy: Networks Time: Sunda
Page 525 and 526:
permanent redistribution of hippoca
Page 527 and 528:
Authors: *T. J. KISPERSKY 1 , J. A.
Page 529 and 530:
Topic: C.06.f. Circuits and systems
Page 531 and 532:
Poster 250. Epilepsy: Networks Time
Page 533 and 534:
esults pinpoint the combined intera
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Anaesthesiology and Intensive Care,
Page 537 and 538:
with altered performance of tasks r
Page 539 and 540:
Title: Oligodendrocytes form couple
Page 541 and 542:
Support: B. Deverman is supported b
Page 543 and 544:
Poster 251. Demyelinating Disorders
Page 545 and 546:
mice lacking the β3 subunit of VGC
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ostral CC, while myelinated or demy
Page 549 and 550:
Disclosures: K.J. Garofalo , None;
Page 551 and 552:
autoimmune diseases, including mult
Page 553 and 554:
Authors: *M. CORTÉS 1 , M. L. ITA
Page 555 and 556:
National Multiple Sclerosis Society
Page 557 and 558:
Disclosures: F.L. Robinson, None; I
Page 559 and 560:
wks (acute CC demyelination) or 12
Page 561 and 562:
nodes were collected at different p
Page 563 and 564:
in the anti-inflammatory cytokines.
Page 565 and 566:
Poster 251. Demyelinating Disorders
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interest, since MBP is thought to b
Page 569 and 570:
Functional studies showed that HBMV
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CD14 and the cytoskeleton proteins
Page 573 and 574:
Abstract: Multiple sclerosis (MS) i
Page 575 and 576:
alance and cognitive changes which
Page 577 and 578:
252. Demyelinating Disorders: Mecha
Page 579 and 580:
glutamate release and postsynaptica
Page 581 and 582:
Aging, LKS Fac. of Med., 4 State Ke
Page 583 and 584:
Abstract: Mitochondrial dynamics (f
Page 585 and 586:
Title: Rotenone reduces Mg2+-depend
Page 587 and 588:
Poster 253. Parkinson's Disease Mod
Page 589 and 590:
striatum respectively, and another
Page 591 and 592:
Authors: J. SHIM 1 , H. KIM 1 , M.
Page 593 and 594:
of the Substantia Nigra (SN) and th
Page 595 and 596:
Program#/Poster#: 254.1/X18 Topic:
Page 597 and 598:
pathology, we compared the expressi
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understood. Glutamate receptor sign
Page 601 and 602:
Authors: *N. N. NEW 1,2 , J. D. JEN
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Poster 254. Schizophrenia: Mutant A
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Topic: C.15.d. Schizophrenia: Mutan
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Page 609 and 610:
Page 611 and 612:
254. Schizophrenia: Mutant Animal M
Page 613 and 614:
Page 615 and 616:
mutations on the genes of molecules
Page 617 and 618:
medications. A genome-wide associat
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ehavioral sensitization. Behavioral
Page 621 and 622:
including muscarinic, serotonergic
Page 623 and 624:
Authors: *L. B. RESSTEL, F. M. A. C
Page 625 and 626:
Title: Mechanisms of the antidepres
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Support: CAPES FAPESP CNPq Title: F
Page 629 and 630:
Page 631 and 632:
255. Mood Disorders: Animal Models
Page 633 and 634:
the prefrontal cortex, amygdala, lo
Page 635 and 636:
This abstract has been authored by
Page 637 and 638:
propagating depressive-like behavio
Page 639 and 640:
suffer from panic disorder. The CCK
Page 641 and 642:
255. Mood Disorders: Animal Models
Page 643 and 644:
Poster 255. Mood Disorders: Animal
Page 645 and 646:
decreased social interaction, indic
Page 647 and 648:
previously identified 17 genes with
Page 649 and 650:
Title: Modulatory effects of comorb
Page 651 and 652:
with anxious temperament in the BNS
Page 653 and 654:
Authors: *S. E. FAHNHORST 1 , M. A.
Page 655 and 656:
256. Anxiety Disorders: Human Bioma
Page 657 and 658:
256. Anxiety Disorders: Human Bioma
Page 659 and 660:
Title: Regulation of human serotoni
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Topic: C.15.l. Other Title: Differe
Page 663 and 664:
Poster 257. Alcohol Intake and Pref
Page 665 and 666:
Poster 257. Alcohol Intake and Pref
Page 667 and 668:
Disclosures: C.E. Schnell, None; R.
Page 669 and 670:
in life. Future studies should not
Page 671 and 672:
co-variation in alcohol and sweet i
Page 673 and 674:
Title: Ethanol binge drinking incre
Page 675 and 676:
Page 677 and 678:
Authors: *O. RICE 1 , M. KRANTZ 2 ,
Page 679 and 680:
P rats provided by the Indiana Alco
Page 681 and 682:
Disclosures: M. Job, None; R.A. Gon
Page 683 and 684:
Poster 258. Molecular and Neurochem
Page 685 and 686:
contemporary stereology. HR but not
Page 687 and 688:
infusions (0.03 mg/kg/infusion) but
Page 689 and 690:
to assess changes in gene transcrip
Page 691 and 692:
Abstract: Nicotine dependence is ma
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Topic: C.16.k. Nicotine Support: Ac
Page 695 and 696:
present study demonstrate that expo
Page 697 and 698:
Abstract: It is widely accepted tha
Page 699 and 700:
Topic: C.16.k. Nicotine Title: Acti
Page 701 and 702:
spiking and the bursts. These resul
Page 703 and 704:
nicotine SA training (0.03 mg/kg/in
Page 705 and 706:
Abstract: Nicotinic acetylcholine r
Page 707 and 708:
vertebrate groups acquired sensitiv
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Authors: M. MIRJANY, *D. S. FABER;
Page 711 and 712:
Support: NIH R01 DC00092 NIH 5T32GM
Page 713 and 714:
Topic: D.02.a. Mechanoreceptors and
Page 715 and 716:
Disclosures: B.N. Buran, None; N. S
Page 717 and 718:
examine potential cell cycle re-ent
Page 719 and 720:
Authors: *R. D. FRISINA 1,2 , S. F.
Page 721 and 722:
Poster 259. Cochlear Mechanorecepto
Page 723 and 724:
compact parametric point process me
Page 725 and 726:
Ungerleider, 1989; Ungerleider and
Page 727 and 728:
260. Objects and Faces in Humans II
Page 729 and 730:
BOLD signal time courses for the fo
Page 731 and 732:
ecognition might depend on represen
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Title: A Bayesian decoder that reco
Page 735 and 736:
Title: Building vision: Splitting t
Page 737 and 738:
Title: Beamforming event-related fi
Page 739 and 740:
Topic: D.04.j. Processing of object
Page 741 and 742:
about non-preferred objects. We tes
Page 743 and 744:
intact. This suggests that the FFA
Page 745 and 746:
Authors: *C. S. KONEN 1,2 , M. A. P
Page 747 and 748:
Title: Simultaneous LFP recordings
Page 749 and 750:
Program#/Poster#: 261.6/CC3 Topic:
Page 751 and 752:
Additionally, the degree of adaptat
Page 753 and 754:
Abstract: Electrophysiological reco
Page 755 and 756:
the temporal visual cortex of monke
Page 757 and 758:
organized at the network level rema
Page 759 and 760:
trend occurred on an individual bas
Page 761 and 762:
Abstract: The sensory inputs used t
Page 763 and 764:
Abstract: In the influential Marr-A
Page 765 and 766:
Fondazione del Monte di Bologna e R
Page 767 and 768:
Poster 262. Visually-Guided Reachin
Page 769 and 770:
showed significant increases in rCB
Page 771 and 772:
was that eye position would dominat
Page 773 and 774:
Center for the Neural Basis of Cogn
Page 775 and 776:
Poster 262. Visually-Guided Reachin
Page 777 and 778:
upper to lower (U-L) position or fr
Page 779 and 780:
standard visuomotor transformations
Page 781 and 782:
DC; 4 District Amputee Care, Washin
Page 783 and 784:
Disclosures: J.N. Van Der Geest, No
Page 785 and 786:
correlated (r=+0.59). In contrast,
Page 787 and 788:
of cMRF reticulotectal axonal termi
Page 789 and 790:
Topic: D.06.c. Eye and head control
Page 791 and 792:
movement. A more complete analysis
Page 793 and 794:
and movement in alert, head-unrestr
Page 795 and 796:
FNRS (Belgium), ESA (EU) Title: Com
Page 797 and 798:
Poster 263. Eye Movements: Eye and
Page 799 and 800:
Topic: D.06.c. Eye and head control
Page 801 and 802:
Poster 263. Eye Movements: Eye and
Page 803 and 804:
neural learning was directly correl
Page 805 and 806:
Abstract: Previously we demonstrate
Page 807 and 808:
Abstract: Several structures in the
Page 809 and 810:
Authors: *S. P. MAHAFFY 1,2 , R. J.
Page 811 and 812:
Topic: D.06.d. Saccades and Pursuit
Page 813 and 814:
Support: DFG SFB 509 Title: Develop
Page 815 and 816:
Page 817 and 818:
trial causes impressive pursuit lea
Page 819 and 820:
orientation was determined from spa
Page 821 and 822:
Abstract: When generating saccades
Page 823 and 824:
Abstract: Cold temperatures are kno
Page 825 and 826:
healthy. These mice were subjected
Page 827 and 828:
Abstract: Peripheral anti-hyperalge
Page 829 and 830:
Title: Transient receptor potential
Page 831 and 832:
stably expressing trkA receptors we
Page 833 and 834:
and decrease in response threshold
Page 835 and 836:
The results demonstrate that 1) TRP
Page 837 and 838:
treatment with estradiol increases
Page 839 and 840:
Topic: D.08.a. Pain transduction mo
Page 841 and 842:
have agonist properties at selectiv
Page 843 and 844:
Abstract: Electrical stimulation ca
Page 845 and 846:
p
Page 847 and 848:
(2006) exhibited lower pain ratings
Page 849 and 850:
and controls, the lowest pain thres
Page 851 and 852:
numeric rating scale (0 - 10). Palm
Page 853 and 854:
Abstract: Capsaicin-desensitization
Page 855 and 856:
Topic: D.08.h. Psychophysics and be
Page 857 and 858:
Disclosures: C. Cosi, None; V. Carl
Page 859 and 860:
ackward translation by a translator
Page 861 and 862:
Abstract: Chronic pain is detriment
Page 863 and 864:
Title: Expression of c-Fos in a rod
Page 865 and 866:
267. Pain: Pain Models II Time: Sun
Page 867 and 868:
head withdrawal to application of v
Page 869 and 870:
Authors: A. A. CHERRO 1 , *H. MARSH
Page 871 and 872:
Support: DFG KFO 107 Kompetenzzentr
Page 873 and 874:
Poster 267. Pain: Pain Models II Ti
Page 875 and 876:
267. Pain: Pain Models II Time: Sun
Page 877 and 878:
functional metabolic impairment ame
Page 879 and 880:
pain had been induced. Respiratory
Page 881 and 882:
mechanical stimulation, and tail wi
Page 883 and 884:
periods of prolonged thermal nocice
Page 885 and 886:
we examined whether the functional
Page 887 and 888:
Authors: *W. A. ECKERT, M. MAHER, D
Page 889 and 890:
Topic: D.08.l. Neuropathic pain: Me
Page 891 and 892:
Program#/Poster#: 268.8/GG5 Topic:
Page 893 and 894:
268. Neuropathic Pain Mechanisms: I
Page 895 and 896:
as non-nociceptive (LTM) or nocicep
Page 897 and 898:
Topic: D.08.l. Neuropathic pain: Me
Page 899 and 900:
and tolbutamide blocked NPo, withou
Page 901 and 902:
understood. The cytokine GRO/KC (gr
Page 903 and 904:
Frey filament with strength of 0.68
Page 905 and 906:
glutamate transporter EAAT2 is the
Page 907 and 908:
GlaxoSmithKline (CASE studentship)
Page 909 and 910:
Poster 269. Pain: Visceral Pain II
Page 911 and 912:
269. Pain: Visceral Pain II Time: S
Page 913 and 914:
Title: Responses of T3 spinal neuro
Page 915 and 916:
Page 917 and 918:
Page 919 and 920:
inhibition for both peptides) in NO
Page 921 and 922:
induced by intracolonic injection o
Page 923 and 924:
Authors: *B. C. YOBURN 1 , S. V. DI
Page 925 and 926:
Abstract: Forced swim produces a de
Page 927 and 928:
increase in expression of CGRP in s
Page 929 and 930:
injections of morphine (15 ug) at 9
Page 931 and 932:
Authors: A. CARRASCO, M. J. LEE, *J
Page 933 and 934:
270. Pain: Opioids and Other Analge
Page 935 and 936:
Alkermes, Inc., A. Employment (full
Page 937 and 938:
Disclosures: N.M. Wilson , None; F.
Page 939 and 940:
(nitric oxide and inflammatory cyto
Page 941 and 942:
MH45361 Title: Increase in antinoci
Page 943 and 944:
Page 945 and 946:
Poster 271. Mechanoreceptors Time:
Page 947 and 948:
endings, never in their axons. In e
Page 949 and 950:
The neurite's cell body resides in
Page 951 and 952:
Support: AFOSR MURI Biologically In
Page 953 and 954:
Page 955 and 956:
Support: NIH MBRS-SCORE grant 1s06G
Page 957 and 958:
CRF than controls. The feeling of e
Page 959 and 960:
whether the increased activation wa
Page 961 and 962:
Support: NIH 1R15NS053442-01A1 NIH
Page 963 and 964:
Poster 272. Kinematics and EMG: Dis
Page 965 and 966:
Disclosures: J.L. Alberts, None; A.
Page 967 and 968:
Adaptation, step lengths initially
Page 969 and 970:
of 65 age-matched control subjects
Page 971 and 972:
CSN Title: Motor patterns typical o
Page 973 and 974:
Abstract: The primate basal ganglia
Page 975 and 976:
Topic: D.15.a. Transmitters and neu
Page 977 and 978:
Disclosures: M.A. de Souza Silva, N
Page 979 and 980:
or the specific NMDA receptor antag
Page 981 and 982:
Psychological and Brain Sci., Johns
Page 983 and 984:
Supported by Cinvestav and Conacyt
Page 985 and 986:
Topic: D.15.a. Transmitters and neu
Page 987 and 988:
induction protocol does not result
Page 989 and 990:
peristimulus time histograms of dop
Page 991 and 992:
Authors: *S. GEISLER, R. A. WISE; B
Page 993 and 994:
Support: CONACyT 50427Q Title: Dopa
Page 995 and 996:
Poster 274. Basal Ganglia: Transmit
Page 997 and 998:
efficacy as a A2A antagonist and as
Page 999 and 1000:
Support: BFI2003-02909 Ramón y Caj
Page 1001 and 1002:
Poster 274. Basal Ganglia: Transmit
Page 1003 and 1004:
observed that adenosine A1 receptor
Page 1005 and 1006:
Authors: *E. JUNG 1 , D.-S. KIM 2 ,
Page 1007 and 1008:
Abstract: Anticipatory postural adj
Page 1009 and 1010:
Poster 275. Posture: Kinematics and
Page 1011 and 1012:
motion captured by a 6-camera Vicon
Page 1013 and 1014:
with the head a linearly actuated p
Page 1015 and 1016:
of the human lower limb for standin
Page 1017 and 1018:
Abstract: Introduction. Studies on
Page 1019 and 1020:
Topic: D.16.d. Kinematics and Muscl
Page 1021 and 1022:
Poster 275. Posture: Kinematics and
Page 1023 and 1024:
data of the head and whole body wer
Page 1025 and 1026:
Program#/Poster#: 275.17/JJ32 Topic
Page 1027 and 1028:
to low targets. Although reach perf
Page 1029 and 1030:
Abstract: Patients with Parkinson
Page 1031 and 1032:
Program#/Poster#: 275.22/KK3 Topic:
Page 1033 and 1034:
was maintained, but aging resulted
Page 1035 and 1036:
standard clinical measures for bala
Page 1037 and 1038:
Program#/Poster#: 275.27/KK8 Topic:
Page 1039 and 1040:
275. Posture: Kinematics and Muscle
Page 1041 and 1042:
Poster 276. Voluntary Movement: Str
Page 1043 and 1044:
Abstract: Previous studies have sug
Page 1045 and 1046:
Support: NIH Grant R01-NS052509 Tit
Page 1047 and 1048:
Poster 276. Voluntary Movement: Str
Page 1049 and 1050:
significantly change. Reaching time
Page 1051 and 1052:
Abstract: [Objective] The purpose o
Page 1053 and 1054:
Stanford University Department of N
Page 1055 and 1056:
novel approach to exploring the rel
Page 1057 and 1058:
Abstract: The contribution of the c
Page 1059 and 1060:
277. Voluntary Movement: Cortical P
Page 1061 and 1062:
Poster 277. Voluntary Movement: Cor
Page 1063 and 1064:
Abstract: Slow finger movements in
Page 1065 and 1066:
Topic: D.17.b. Cortical planning an
Page 1067 and 1068:
Page 1069 and 1070:
simulate the conditions of active m
Page 1071 and 1072:
Title: Primary motor cortex reflect
Page 1073 and 1074:
Topic: D.17.b. Cortical planning an
Page 1075 and 1076:
unperturbed reaching movements (bas
Page 1077 and 1078:
Authors: *S. BESTMANN 1 , M. MUNNEK
Page 1079 and 1080:
elements are also part of a squirre
Page 1081 and 1082:
15, 30, and 60κA. The stimulus fre
Page 1083 and 1084:
Authors: *D. M. GRIFFIN 1 , H. M. H
Page 1085 and 1086:
Page 1087 and 1088:
Page 1089 and 1090:
dynamics which is not substantially
Page 1091 and 1092:
uncorrected) during compatible tria
Page 1093 and 1094:
Poster 278. Sex Differences I Time:
Page 1095 and 1096:
Disclosures: L.M. Tejada , None; E.
Page 1097 and 1098:
distribution of ER-containing neuro
Page 1099 and 1100:
Support: NIH grant RO1 NS055218 Tit
Page 1101 and 1102:
Page 1103 and 1104:
Disclosures: B.M. Nugent, None; J.M
Page 1105 and 1106:
Page 1107 and 1108:
Program#/Poster#: 278.16/MM9 Topic:
Page 1109 and 1110:
Canada Foundation for Innovation Mi
Page 1111 and 1112:
Topic: E.01.d. Development Support:
Page 1113 and 1114:
Program#/Poster#: 279.1/MM15 Topic:
Page 1115 and 1116:
279. Steroids and Plasticity I Time
Page 1117 and 1118:
Support: NS07080 Title: Acute and s
Page 1119 and 1120:
Poster 279. Steroids and Plasticity
Page 1121 and 1122:
activation on principal cell dendri
Page 1123 and 1124:
castration to deplete circulating t
Page 1125 and 1126:
hippocampus are major targets of st
Page 1127 and 1128:
NINDS Grant NS48141 Title: Using mi
Page 1129 and 1130:
Poster 279. Steroids and Plasticity
Page 1131 and 1132:
NIH grant HD18185 NIH grant MH62677
Page 1133 and 1134:
hippocampus (p
Page 1135 and 1136:
corticosterone, brain monoamine uti
Page 1137 and 1138:
Support: NSF grant 0549987 to TD HD
Page 1139 and 1140:
Page 1141 and 1142:
suggested that dominant and submiss
Page 1143 and 1144:
cancer increases the prevalence of
Page 1145 and 1146:
Poster 280. Stress and the Brain: S
Page 1147 and 1148:
Poster 280. Stress and the Brain: S
Page 1149 and 1150:
augmented maternal care is converte
Page 1151 and 1152:
Authors: *A. S. IVY 1 , K. L. BRUNS
Page 1153 and 1154:
Topic: E.06.e. Early life experienc
Page 1155 and 1156:
281. Stress and the Brain: Early Li
Page 1157 and 1158:
Telethon Grant GGP05220, Italy Titl
Page 1159 and 1160:
Title: Early-life stress is associa
Page 1161 and 1162:
Topic: E.06.e. Early life experienc
Page 1163 and 1164:
Page 1165 and 1166:
aversion, further research is neede
Page 1167 and 1168:
than the controls (p
Page 1169 and 1170:
compared to unstressed controls. Si
Page 1171 and 1172:
Title: Maternal deprivation affects
Page 1173 and 1174:
Disclosures: N. Lajud, None; L. Tor
Page 1175 and 1176:
SNB motoneuron development. In addi
Page 1177 and 1178:
autonomic control in juvenile (i.e.
Page 1179 and 1180:
known to be susceptible to hypoxic
Page 1181 and 1182:
stress-related psychiatric disorder
Page 1183 and 1184:
Page 1185 and 1186:
and found that there was a greater
Page 1187 and 1188:
and cognition in the adult brain. T
Page 1189 and 1190:
10:137-143). Here, microarray profi
Page 1191 and 1192:
MH 38273 HD 05751 Title: Corticotro
Page 1193 and 1194:
Authors: *B. N. SRIKUMAR, V. PRIYA,
Page 1195 and 1196:
Authors: *K. J. LEE 1 , H.-J. KIM 1
Page 1197 and 1198:
Program#/Poster#: 282.18/OO25 Topic
Page 1199 and 1200:
Program#/Poster#: 282.20/OO27 Topic
Page 1201 and 1202:
Page 1203 and 1204:
Poster 283. Stress-Regulated Pathwa
Page 1205 and 1206:
the post-fatigue scan, the fatigue
Page 1207 and 1208:
show a higher prevalence in females
Page 1209 and 1210:
i.v. sodium lactate. Recently, we r
Page 1211 and 1212:
Support: MRC Project Grant (UK) Mar
Page 1213 and 1214:
Program#/Poster#: 283.10/PP6 Topic:
Page 1215 and 1216:
52619, B. Research Grant (principal
Page 1217 and 1218:
priming experiments (daily bilatera
Page 1219 and 1220:
Disclosures: I. Bantounas, None; Y.
Page 1221 and 1222:
ut the biological role and tissue d
Page 1223 and 1224:
Title: Altered wiring of emotional-
Page 1225 and 1226:
Topic: E.06.f. Stress modulated pat
Page 1227 and 1228:
Poster 283. Stress-Regulated Pathwa
Page 1229 and 1230:
group received 6-hour daily restrai
Page 1231 and 1232:
embryonic and early postnatal perio
Page 1233 and 1234:
stressed vs. unstressed rats. In pa
Page 1235 and 1236:
Page 1237 and 1238:
Poster 284. Regulation of Food Inta
Page 1239 and 1240:
functional assays, respectively and
Page 1241 and 1242:
284. Regulation of Food Intake and
Page 1243 and 1244:
neurons respond to metabolic and se
Page 1245 and 1246:
to evaluate the validity of the ass
Page 1247 and 1248:
NIH Grant RR021945 Title: Innervati
Page 1249 and 1250:
Research Foundation (JDRF), C. Othe
Page 1251 and 1252:
vago-vagal reflexes suggest that no
Page 1253 and 1254:
neurons that are defined by their e
Page 1255 and 1256:
LCR rats were given ad libitum acce
Page 1257 and 1258:
day 20 to 40 (restricted-running),
Page 1259 and 1260:
HL60296 MH63323 Title: Sleep-relate
Page 1261 and 1262:
285. Sleep: Molecular, Cellular and
Page 1263 and 1264:
whether focal rescue of orexin rece
Page 1265 and 1266:
Program#/Poster#: 285.7/QQ23 Topic:
Page 1267 and 1268:
Poster 285. Sleep: Molecular, Cellu
Page 1269 and 1270:
References: 1. S. M. Reppert, D. R.
Page 1271 and 1272:
Title: T-type (Ca[V]3) calcium chan
Page 1273 and 1274:
explanation for the increased sleep
Page 1275 and 1276:
Title: In C57BL/6J (B6) mouse the G
Page 1277 and 1278:
Baghdoyan, Sepracor, B. Research Gr
Page 1279 and 1280:
immobilisation stress in 5-HTT-/- m
Page 1281 and 1282:
Authors: C.-L. LIANG 1 , *G. A. MAR
Page 1283 and 1284:
Support: NIMH (P20 MH077967) NIH Di
Page 1285 and 1286:
Poster 285. Sleep: Molecular, Cellu
Page 1287 and 1288:
as a reference since „barrel' AF
Page 1289 and 1290:
Authors: I. C. TENG 1 , P. TIAN 1 ,
Page 1291 and 1292:
Support: NIH Grant NS-051188 NIH Gr
Page 1293 and 1294:
Poster 286. Imaging the Nervous Sys
Page 1295 and 1296:
esponses were observed to those mea
Page 1297 and 1298:
CYP450 epoxygenase and inward recti
Page 1299 and 1300:
Title: Discovery of a neuronal popu
Page 1301 and 1302:
hemodynamic response. Further, diff
Page 1303 and 1304:
Disclosures: V. Manda , None; R.K.
Page 1305 and 1306:
membrane. This represents the first
Page 1307 and 1308:
to wide-band noise at the level of
Page 1309 and 1310:
transmission electron microscopy (T
Page 1311 and 1312:
Program#/Poster#: 287.9/RR3 Topic:
Page 1313 and 1314:
Authors: *K. DEVRAJ 1 , A. MOKASHI
Page 1315 and 1316:
arranged in three clusters (Pcdh-α
Page 1317 and 1318:
Page 1319 and 1320:
ecent but currently unavailable con
Page 1321 and 1322:
processes such as language, plannin
Page 1323 and 1324:
Topic: F.01.f. Working memory Suppo
Page 1325 and 1326:
indicated that during working memor
Page 1327 and 1328:
Executive function impairment is a
Page 1329 and 1330:
288. Working Memory: Disorders, Gen
Page 1331 and 1332:
Topic: F.01.f. Working memory Suppo
Page 1333 and 1334:
Program#/Poster#: 288.16/RR23 Topic
Page 1335 and 1336:
demonstrating how they span the dif
Page 1337 and 1338:
Abstract: Central synaptic dopamine
Page 1339 and 1340:
Title: Connectivity of the human wo
Page 1341 and 1342:
Disclosures: S. Ganguli, None; B.D.
Page 1343 and 1344:
ack and 2-back) in which they press
Page 1345 and 1346:
Authors: *M. K. VAN VUGT 1 , M. J.
Page 1347 and 1348:
Authors: *J. NG 1 , C. Y. TANG 1,2
Page 1349 and 1350:
Disclosures: E.L. Eaves, None; C.Y.
Page 1351 and 1352:
Topic: F.01.g. Decision making and
Page 1353 and 1354:
ACC projects to locus coeruleus (LC
Page 1355 and 1356:
composed of disparate red-blue sphe
Page 1357 and 1358:
which the timing of the response wa
Page 1359 and 1360:
Poster 289. Human Decision Making T
Page 1361 and 1362:
Program#/Poster#: 289.12/RR48 Topic
Page 1363 and 1364:
load or task switching, suggesting
Page 1365 and 1366:
Authors: *M. S. SCULLY 1,3 , B. AND
Page 1367 and 1368:
Title: Dopamine D3 receptor blockad
Page 1369 and 1370:
Title: NCAM signaling through the F
Page 1371 and 1372:
290. Animal Cognition and Behavior:
Page 1373 and 1374:
Authors: *E. E. BIGNEY, H. K. TAUKU
Page 1375 and 1376:
Topic: F.02.j. Learning and memory:
Page 1377 and 1378:
Poster 290. Animal Cognition and Be
Page 1379 and 1380:
290. Animal Cognition and Behavior:
Page 1381 and 1382:
Page 1383 and 1384:
Page 1385 and 1386:
evoked cholinergic signal amplitude
Page 1387 and 1388:
Abstract: Deficient sensory inhibit
Page 1389 and 1390:
1 EPHE, Univ. Montpellier II, INSER
Page 1391 and 1392:
Page 1393 and 1394:
grants already received); M.P. Kast
Page 1395 and 1396:
from young rats in order to clarify
Page 1397 and 1398:
Abstract: Enhanced vigilance and at
Page 1399 and 1400:
Page 1401 and 1402:
Page 1403 and 1404:
Page 1405 and 1406:
on lever presses. However, 10mg/kg
Page 1407 and 1408:
NIDA Training Grant DA07237, JWK Ti
Page 1409 and 1410:
of pharmacological treatments has p
Page 1411 and 1412:
Title: Contextual fear memory is im
Page 1413 and 1414:
Topic: F.02.j. Learning and memory:
Page 1415 and 1416:
affecting cognitive, motor, or expl
Page 1417 and 1418:
treatment consisted on 11 injection
Page 1419 and 1420:
Abstract: Background: Dopamine (DA)
Page 1421 and 1422:
Title: Triple knockouts of the mous
Page 1423 and 1424:
Support: Virginia Tobacco Settlemen
Page 1425 and 1426:
1 Dept. of Neurol., Nagoya City Uni
Page 1427 and 1428:
suggest that decreased activity in
Page 1429 and 1430:
292. Acetylcholine, Neurotrophins,
Page 1431 and 1432:
hemifield and tested in the opposit
Page 1433 and 1434:
the β4 nAChR subunit. Mice were te
Page 1435 and 1436:
Title: Cortical brain derived neuro
Page 1437 and 1438:
Page 1439 and 1440:
Center for Behavioral Neuroscience
Page 1441 and 1442:
Poster 293. Startle and Modulation
Page 1443 and 1444:
percentage of open arm entries. For
Page 1445 and 1446:
Topic: F.02.f. Fear and aversive le
Page 1447 and 1448:
Disclosures: J. Lass-Hennemann, Non
Page 1449 and 1450:
Program#/Poster#: 293.10/SS38 Topic
Page 1451 and 1452:
Disclosures: X. Zhang , None; Y. Zh
Page 1453 and 1454:
Also, there is a gradient of c-Fos
Page 1455 and 1456:
learning task, after which the baso
Page 1457 and 1458:
Authors: K. OVEREEM 1,2 , *G. E. SC
Page 1459 and 1460:
294. Gene Expression and Fear Learn
Page 1461 and 1462:
does not reach the level of overt f
Page 1463 and 1464:
Neuropsychopharmacol. in press). In
Page 1465 and 1466:
Authors: *P. GARCÍA-DELATORRE, C.
Page 1467 and 1468:
Page 1469 and 1470:
Poster 295. Memory Consolidation, R
Page 1471 and 1472:
Authors: S. A. BAELLA 1 , S. D. IÑ
Page 1473 and 1474:
Page 1475 and 1476:
Topic: F.02.h. Memory modulation, c
Page 1477 and 1478:
Page 1479 and 1480:
Page 1481 and 1482:
Page 1483 and 1484:
Page 1485 and 1486:
to in vivo microdialysis to measure
Page 1487 and 1488:
Authors: E. CASTRO, J. Y. LAGUNA-TO
Page 1489 and 1490:
time-limited role in the transfer t
Page 1491 and 1492:
allow large ensembles of hippocampa
Page 1493 and 1494:
Title: Further characterization of
Page 1495 and 1496:
296. Learning and Memory: Physiolog
Page 1497 and 1498:
Disclosures: S. Yamamoto, None; H.
Page 1499 and 1500:
een difficult to examine whether th
Page 1501 and 1502:
Topic: F.02.i. Learning and memory:
Page 1503 and 1504:
memory circuitry by ketamine that i
Page 1505 and 1506:
Authors: *A. ARDESTANI 1 , F. DARVA
Page 1507 and 1508:
Page 1509 and 1510:
Poster 297. Social Recognition and
Page 1511 and 1512:
administration of the mu-opioid sel
Page 1513 and 1514:
memory (SRM). If the ITI is 60 min,
Page 1515 and 1516:
Page 1517 and 1518:
social interactions. Supported by N
Page 1519 and 1520:
of mate choice copying and the “t
Page 1521 and 1522:
297. Social Recognition and Partner
Page 1523 and 1524:
we examined the neuronal activity i
Page 1525 and 1526:
Recent evidence indicates that the
Page 1527 and 1528:
Abstract: Previous studies have fou
Page 1529 and 1530:
Authors: *D. K. TAYLOR, K. KOTWICA,
Page 1531 and 1532:
stimulation lever back to the maxim
Page 1533 and 1534:
feeding produced by predator stress
Page 1535 and 1536:
(DAT) knockdown mice, with only 10%
Page 1537 and 1538:
intraorally administered sucrose so
Page 1539 and 1540:
eactions to tastes, possibly implic
Page 1541 and 1542:
the amygdala. Surprisingly, sucrose
Page 1543 and 1544:
21680 administration decreased base
Page 1545 and 1546:
We have studied the effect of OSU-6
Page 1547 and 1548:
NIMH Title: The N-terminal domain o
Page 1549:
animals was observed. A history of
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