[Abstract Title]. - Society for Neuroscience

In contrast, expressing ASIC1a in the BLA increased the recollection and expression of fear
memory, and restored context evoked freezing in the ASIC1a-null mice to normal levels.
Together, these studies demonstrate that AAV1-mediated gene transfer combined with
traditional knockout technology can be a valuable tool in probing the complex relationship
between genes, neural circuits, and behavior. Furthermore they suggest that ASIC1a expression
in the BLA is sufficient to rescue some fear behaviors in the ASIC1a-null mice, but not all.
Finally, these results demonstrate an unusual dissociation, the unexpected restoration of memory
in the face of impaired acquisition.
Disclosures: M.W. Coryell , NRSA, B. Research Grant (principal investigator, collaborator or
consultant and pending grants as well as grants already received); A.M. Wunsch, None; J.
Haenfler, None; J.E. Allen, None; M.J. Welsh, None; J.A. Wemmie, NARSAD, B. Research
Grant (principal investigator, collaborator or consultant and pending grants as well as grants
already received).
Poster
294. Gene Expression and Fear Learning
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 294.10/SS50
Topic: F.02.d. Cognitive learning and memory systems
Title: Transcriptional co-regulators and memory processes: behavioral phenotyping of RIP140
knock-out mice
Authors: *F. DUCLOT 1 , S. FRITSCH 2 , M. G. PARKER 3 , V. CAVAILLÈS 2 , T. MAURICE 1 ;
1 INSERM U710, UM II / EPHE, Montpellier, France; 2 Montpellier Cancer Res. Inst.,
Montpellier, France; 3 Inst. for Reproductive and Developmental Biol., London, United Kingdom
Abstract: Receptor-interacting protein 140 (RIP140) is a negative transcriptional co-regulator of
gene expression, which was first described as recruited by estrogen receptor alpha (Cavailles et
al., 1995, EMBO J. 14:3741). In fact, RIP140 interacts with many nuclear receptors, including
retinoic acid receptors or glucocorticoid receptors. Recruitment of RIP140 results in inhibition of
nuclear receptor target gene expression through different repressive domains interacting with
histone deacetylase (HDAC) or C-terminal binding proteins. Chen et al. (2004, Mol Cell
Endocrinol. 226:43) provided evidences for a competition between RIP140 and the
transcriptional co-activator p300/CBP-associated factor (PCAF) for recruitment by nuclear
receptor. PCAF bears an intrinsic histone acetyltransferase activity, remodeling chromatin
structure towards a more decompacted state associated to transcriptional activation. We recently
analyzed the role of PCAF in learning and memory process (Maurice et al., 2008,