[Abstract Title]. - Society for Neuroscience

Poster
247. Parkinson's Disease Interventions: Animal and Clinical Models
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 247.8/S3
Topic: C.02.d. Therapies
Support: KRF-2005-500-J00702
Kyung Hee University
Title: Preventive effects of CAA on 6-hydroxydopamine-induced dopaminergic dysfunction in
mice
Authors: *L. JIN 1,2,3 , H. KU 4 , Y. CHOI 6,5 , M. JEONG 6,5 , Y. KIM 7 , Y. SON 8 , J. LEE 9 , S.
LIM 10,11,12 ;
2 Dept. of Meridian and Acupuncture, Col. of Basic Oriental Medicinal Sci., 3 Dept. of Applied
Korean Med., 4 Dept. of Applied Korean Medicine, Grad. School, Kyung Hee Univ., 5 WHO
Collaborating Ctr. for Traditional Medicine, East-West Med. Res. Inst., 1 Kyung Hee Univ.,
Seoul, Republic of Korea; 6 Dept. of Meridian and Acupuncture, Col. of Basic Oriental Medicinal
Science, Kyung Hee Univ., Seoul, Republic of Korea; 7 Dept. of Pharmacology, Col. of
Medicine, Seoul Natl. Univ., Seoul, Republic of Korea; 8 Dept. of Genet. Engineering, Col. of
Life Science, Kyung Hee University,, Youngin, Republic of Korea; 9 Dept. of Herbology, Col. of
Korean Medicine, Dongguk University, Seokjang-dong, Gyeongju, Gyeongju, Republic of
Korea; 10 WHO Collaborating Ctr. for Traditional Medicine, East-West Med. Res. Institute, and
Depar, kyung Univ., Seoul, Republic of Korea; 11 Dept. of Meridian and Acupuncture, Col. of
Basic Oriental Medicinal Sci., Kung Hee Univ., Seoul, Republic of Korea; 12 Dept. of Applied
Korean Med., kyung Hee Univ., Seoul, Republic of Korea
Abstract: This study was conducted to evaluate the effects of a combined extract of CAA on
dopaminergic dysfunction caused by 6-hydroxydopamine (6-OHDA) in mice. CAA is a
combined extract of Cinnamomi Ramulus, Anemarrhenae Rhizoma, and Alpiniae Officinari
Rhizoma. Levels of dopamine and its metabolites (3,4-dihydroxyphenylacetic acid (DOPAC) and
homovanilic acid (HVA)) in the striatum were markedly reduced respectively, compared to the
control group seven days after 6-OHDA injection. However, CAA administration increased
significantly striatal dopamine and its metabolites in a dose-dependent manner. Tyrosine
hydroxylase (TH) and dopamine transporter (DAT) expression was reduced by 6-OHDA
injection, but increased significantly by CAA administration. Such results suggest that CAA
could prevent the dopaminergic dysfunction caused by 6-OHDA in mice and may be useful in
preventing and treating Parkinson‟s disease (PD). Because our study has not dealt with CAA‟s