[Abstract Title]. - Society for Neuroscience

mechanical stimulation, and tail withdrawal latency to thermal stimulation. The thresholds were
evaluated on postnatal day 7, 16, 23, and at the age of 1, 2, 3, 6, 9, 12, 15 and 18 months in
forelimbs, hinds and tail. As far as thermal stimulation is concerned, we could observe
oscillation of withdrawal latencies. Nociceptive thresholds were lowest at PD 7 and then
increased to maximum at weaning period. Since the age of 1 month the thresholds remained
unchanged but with two peaks of decrease - at the age of 2 and 9 months. The oscillations were
expressed most in tail withdrawal latency and least in forelimb withdrawal latency. Comparing
fore and hind limb withdrawal latency it was found that the latency was shorter in forelimbs
since weaning. No increase of nociceptive threshold was seen in old rats. Concerning mechanical
stimulation, withdrawal pressure increased until weaning period and remained unchanged
afterwards with decrease in the oldest groups (at the age of 15 and 18 months). It is suggested
that nociceptive threshold depends on age until the age of 1 month, while in adult animals the
withdrawal latency to thermal stimulation depends rather on external factors like season, air
temperature and/or humidity. In the oldest groups moderate decrease of withdrawal pressure
suggests relative importance of inhibitory pain system deficit.
Disclosures: S. Vaculin, None; M. Franek, None.
Poster
267. Pain: Pain Models II
Time: Sunday, November 16, 2008, 1:00 pm - 5:00 pm
Program#/Poster#: 267.24/FF30
Topic: D.08.j. Pain models
Title: A retrospective study assessing the quality of reporting materials and methods in the
preclinical pain primary literature
Authors: *J. M. TALL, J. BACKO;
Biol. Sci., Youngstown State Univ., Youngstown, OH
Abstract: Numerous studies have shown that external factors, such as housing conditions and
diet, affect data collected from laboratory animals. To promote consistency among laboratories,
it is essential that all components of the animal treatment, laboratory environment, and animal
care facility be clearly reported when publishing the results from preclinical investigations. This
inquiry was conducted to assess the quality of reporting materials and methods in the preclinical
primary literature by conducting a retrospective study. Research databases used to search for the
journal articles included ISI Web of Knowledge, Medline, and Biological Abstracts. Within
these databases, the search was limited to peer-reviewed articles, written in English, and
published in 2007. Inclusion criteria included the words "pain" AND "rats" AND "behavior" in